The introduction of antimicrobial agents in veterinary and human
medicine has been one of the most important medical achievements
in the 20th century. However, soon after the
introduction of antimicrobial agents, bacteria with acquired
resistance emerged and antimicrobial resistance is today so
widespread that it threatens the future effective use of
antimicrobial agents. The use of antimicrobial agents is the main
factor in selection and spread of antimicrobial resistance, even
though the relationship may be complex.
There is now increasing awareness
of the potential problems on human health caused by antimicrobial
resistance among food producing animals. As
antimicrobial resistance develops in the animal reservoir, the
resistance may be tranfered to humans, either through
contact or via the food chain. The transfer may include
resistant zoonotic bacteria causin direct infection in
the humans, or with commensal bacteria from wich the
resistance genes may be transferred to the commensal
bacteria on the human surface or in the gut.
I perform research and advisory services concerning methods for
monitoring antimicrobial use and analysis of associations between
antimicrobail use an development of antimicrobial
resistance. I contibute to the annual DANMAP report, that
monitors the antimicrobial use and resistance development in
animals foods and humans.
The pupose of the surveillance and research is to identify means
of limiting the development of antimicrobial resistance in
animals and the spread to humans, in particular regarding the
critically important antimicrobial. Critically important
antimicrobials are identified by the WHO and other
international organs as the antimicrobials of greatest importance
to human health.