Postdoc in comparative genomics and omics-driven eukaryotic genome minimization

DTU Bioengineering
onsdag 13 sep 17

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Frist 11. oktober 2017
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Department of Biotechnology and Biomedicine is a major Danish research and teaching department in the field of systems biology and is involved in a wide range of research activities within its field.

We are seeking an ambitious postdoc with a documented history of scientific excellence to be affiliated with the Network Engineering (NetEng) group and with the Eukaryotic Molecular Cell Biology group as well as collaborations into other groups at the department.

The NetEng group has a focus on industrial biotechnology and the application of systems biology tools to understand and improve the cell factory. The group is currently 15 people and in the process of expanding by several additional members, where this position will be placed in one of our focus areas: Aspergillus cell factories.

The position is funded by a grant from the Independent Research Fund Denmark.

Responsibilities and tasks
Fungi of the genus Aspergillus are of large economic importance due to their widespread application in industry and their natural capabilities as highly efficient cell factories. In particular, the Aspergilli are natural enzyme producers, and preferred hosts for heterologous enzyme production, but some species also play roles in plant, animal, and human pathogenicity. All known species produce a wide range of bioactive compounds. This project is a part of our long-term efforts to whole-genome sequence the entire fungal genus of Aspergillus, more than 350 species, and to utilize this information for both fundamental and applied research, thereby building superior fungal cell factories and fungal products for the future.

This postdoctoral position offers the unique opportunity to work with high-quality genome sequences for an entire eukaryotic genus and employ them with state-of-the-art genome engineering and editing. Specifically, the post.doc will be a part of a team of three staff members (one PhD student and a technician), where the goal is to reduce the genome size of an Aspergillus species significantly, thereby both studying the effects of reducing the genome, and following the hypothesis that a leaner genome will generate a superior strain for industrial purposes.

The postdoc will be responsible for daily management of the project in collaboration with the PI and co-PIs.

The position will also include:

  • Co-supervision of one or more PhD students
  • Teaching activities under the course portfolio of the Department
Qualifications
Candidates should have a PhD degree or equivalent.

Further qualifications:
The successful candidate should have experience with several of the following:
  • Writing publications for leading journals in the field
  • Fungal molecular biology and genetic engineering based on USER cloning or Gibson assembly
  • Data analysis from one or more of the following omics techniques:
    • Genomics
    • Transcriptomics
    • Proteomics
  • Management of large datasets
It would furthermore be advantageous, but not essential, for the candidate to have knowledge of, or experience with the following:
  • Supervision of students
  • Programming in Python, R, or Perl.
  • Management of multiple projects
  • Robotics for PCR, vector design, or strain construction
We offer
We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.

Salary and terms of employment
The appointment will be based on the collective agreement with the Confederation of Professional Associations. The allowance will be agreed with the relevant union.

The period of employment is 2 years.

Further information
Further information may be obtained from Professor MSO Mikael Rørdam Andersen, tel.: +45 4525 2675, preferentially by mail to mr@bio.dtu.dk.

You can read more about Department of Biotechnology and Biomedicine and the research groups on www.bioengineering.dtu.dk and about Prof. Andersen on www.staff.dtu.dk/miran.

Application procedure
Please submit your online application no later than 11 October 2017. Apply online at www.career.dtu.dk.

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill in the online application form, and attach all your materials in English in one PDF file. The file must include:
  • Application (cover letter)
  • CV
  • Diploma (MSc/PhD)
  • List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) conducts research, educates future bio-engineers, provides scientific advice and innovate within the areas of microbiology, biochemistry, biotechnology and biomedicine. The research at DTU Bioengineering is at the highest international level and focuses on the societal and scientific challenges within the field. Research is conducted within three main areas: Microbial ecology and physiology, Industrial biotechnology and cell factories, and Biomedicine and health. The department has extensive collaboration with national and international research units and industries. DTU Bioengineering has approx. 150 employees, of which 2/3 is scientific staff. The department is located at DTU Lyngby Campus.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,600 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.