Engineering strategies aimed at control of acidification rate of lactic acid bacteria

Martinussen, Jan ; Solem, Christian ; Holm, Anders Koefoed ; Jensen, Peter Ruhdal

in journal: Current Opinion in Biotechnology (ISSN: 0958-1669) (DOI: http://dx.doi.org/10.1016/j.copbio.2012.11.009), vol: 24, issue: 2, pages: 124-129, 2013

Type: Journal article - Journal article

DOI: 10.1016/j.copbio.2012.11.009

The PurR regulon in Lactococcus lactis – transcriptional regulation of the purine nucleotide metabolism and translational machinery

Jendresen, Christian Bille ; Martinussen, Jan ; Kilstrup, Mogens

in journal: Microbiology (ISSN: 1350-0872) (DOI: http://dx.doi.org/10.1099/mic.0.059576-0), vol: 158, issue: 8, pages: 2026-38, 2012

Type: Journal article - Journal article

DOI: 10.1099/mic.0.059576-0

Evaluation of cell factory performance through determination of intracellular metabolites using LC-MS/MS

Magdenoska, Olivera ; Martinussen, Jan ; Nielsen, Kristian Fog ; Thykær, Jette

in journal: New Biotechnology (ISSN: 1871-6784) (DOI: http://dx.doi.org/10.1016/j.nbt.2012.08.413), vol: 29S, 2012

Type: Conference abstract in journal - Conference abstract in journal

Presented at: 15th European Congress on Biotechnology, Istanbul

DOI: 10.1016/j.nbt.2012.08.413

Engineering strategies aimed at control of acidification rate and product formation of lactic acid bacteria

Martinussen, Jan ; Solem, Christian ; Holm, Anders Koefoed ; Jensen, Peter Ruhdal

in journal: Current Opinion in Biotechnology (ISSN: 0958-1669) (DOI: http://dx.doi.org/dx.doi.org/10.1016/j.copbio.2012.11.009), vol: 24, pages: 1-3, 2012

Type: Journal article - Journal article

DOI: dx.doi.org/10.1016/j.copbio.2012.11.009

Characterization of the molecular and genetic regulation of the nucleotide metabolism in Lactococcus lactis

Jendresen, Christian Bille ; Kilstrup, Mogens ; Martinussen, Jan

Type: Ph.d. thesis - Ph.d. thesis

A simplified method for rapid quantification of intracellular nucleoside triphosphates by one-dimensional thin-layer chromatography

Jendresen, Christian Bille ; Kilstrup, Mogens ; Martinussen, Jan

in journal: Analytical Biochemistry (ISSN: 0003-2697) (DOI: http://dx.doi.org/10.1016/j.ab.2010.10.029), vol: 409, issue: 2, pages: 249-259, 2011

Type: Journal article - Journal article

DOI: 10.1016/j.ab.2010.10.029

Experimental methods and modeling techniques for description of cell population heterogeneity

Lencastre Fernandes, Rita ; Nierychlo, M. ; Lundin, L. ; Pedersen, Anne Egholm ; PuentesTellez, P. E. ; Dutta, A. ; Carlqvist, Magnus ; Bolic, Andrijana ; Schäpper, Daniel ; Brunetti, Anna Chiara ; Helmark, Søren ; Heins, Anna-Lena ; Jensen, Anker Degn ; Nopens, I. ; Rottwitt, Karsten ; Szita, Nicolas ; van Elsas, J. D. ; Nielsen, P. H. ; Martinussen, Jan ; Sørensen, S. J. ; Eliasson Lantz, Anna ; Gernaey, Krist

in journal: Biotechnology Advances (ISSN: 0734-9750) (DOI: http://dx.doi.org/10.1016/j.biotechadv.2011.03.007), vol: 29, issue: 6, pages: 575-599, 2011

Type: Journal article - Journal article

DOI: 10.1016/j.biotechadv.2011.03.007

Nucleotide Metabolism

Martinussen, Jan ; Willemoës, M. ; Kilstrup, Mogens

part of: Comprehensive Biotechnology (ISBN: 978-0-08-088504-9), pages: 91-107, 2011, Elsevier Science,

Type: Book chapter - Book chapter

Two nucleoside transporters in Lactococcus lactis with different substrate specificities

Martinussen, Jan ; Sørensen, Claus ; Jendresen, Christian Bille ; Kilstrup, Mogens

in journal: Microbiology (ISSN: 1350-0872) (DOI: http://dx.doi.org/10.1099/mic.0.039818-0), vol: 156, pages: 3148-3157, 2010

Type: Journal article - Journal article

DOI: 10.1099/mic.0.039818-0

Strains of Lactococcus lactis with a partial pyrimidine requirement show sensitivity toward aspartic acid

Wadskov-Hansen, Steen Lyders Lerche ; Martinussen, Jan

in journal: Le Lait (Print) (ISSN: 0023-7302) (DOI: http://dx.doi.org/10.1051/dst/2009001), vol: 89, issue: 2, pages: 125-137, 2009

Type: Journal article - Journal article

DOI: 10.1051/dst/2009001

An optimized method for measurements of nucleotide and PRPP pools applied to the evaluation of a model of PurR-mediated activation in Lactococcus lactis

Jendresen, Christian Bille ; Kilstrup, Mogens ; Martinussen, Jan

Type: Poster - Poster

Presented at: 7th Symposium of Food Microbiology, Helsingør

An optimized method for measurements of nucleotide and PRPP pools applied to the evaluation of a model of PurR-mediated activation in Lactococcus lactis

Jendresen, Christian Bille ; Kilstrup, Mogens ; Martinussen, Jan

Type: Poster - Poster

Presented at: 3rd Congress of European Microbiologists, Goteborg

Activation of purine biosynthetic gene expression by PurR in Lactococcus lactis

Jendresen, Christian Bille ; Kilstrup, Mogens ; Martinussen, Jan

Type: Poster - Poster

Presented at: 9th Symposium on Lactic Acid Bacteria, Egmond aan Zee

Plasmid pCS1966, a new selection/counterselection tool for strain construction in Lactic Acid Bacteria based on the oroP gene encoding an orotate transporter from Lactococcus lactis

Solem, Christian ; Defoor, Els Marie Céline ; Jensen, Peter Ruhdal ; Martinussen, Jan

in journal: Applied and Environmental Microbiology (ISSN: 0099-2240) (DOI: http://dx.doi.org/10.1128/AEM.00134-08), vol: 74, issue: 15, pages: 4772-4775, 2008

Type: Journal article - Journal article

DOI: 10.1128/AEM.00134-08

Transcriptome analysis of the Lactococcus lactis ArgR and AhrC regulons

Larsen, Rasmus ; van Hijum, Sacha A. F. T. ; Martinussen, Jan ; Kuipers, Oscar P. ; Kok, Jan

in journal: Applied and Environmental Microbiology (ISSN: 0099-2240) (DOI: http://dx.doi.org/10.1128/AEM.00117-08), vol: 74, issue: 15, pages: 4768-4771, 2008

Type: Journal article - Journal article

DOI: 10.1128/AEM.00117-08

The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and is functional in both Gram-positive and Gram-negative bacteria

Defoor, E ; Kryger, M ; Martinussen, Jan

in journal: Microbiology (ISSN: 0026-2617), issue: 153, pages: 3645-3659, 2007

Type: Journal article - Journal article

The orotate transporter oroP from Lactococcus lactis can be used both as a very efficient, food-grade selection and counter-selection marker for strain construction in many different organisms

Martinussen, Jan ; Defoor, E

Type: Conference abstract for conference - Conference abstract for conference

Presented at: European Congress of Chemical Engineering - 6, Copenhagen

Regulation of pyrG gene expression in Lactococcus lactis is controlled by the amount of CTP through an attenuator mechanism involving reiterative transcription also known as stuttering

Martinussen, Jan

Type: Conference abstract for conference - Conference abstract for conference

Presented at: European Congress of Chemical Engineering - 6, Copenhagen

Purine nucleosides and Cytidine uptake in Lactococcus lactis share a common transporter of the ABC type

Martinussen, Jan

Type: Conference abstract for conference - Conference abstract for conference

Presented at: European Congress of Chemical Engineering - 6, Copenhagen

Analysis of plasmid pDBORO – A plasmid encoding an orotate transporter from Lactococcus lactis subsp. lactis biovar. diacetylactis strain DB0410

Martinussen, Jan ; Defoor, Els Marie Céline

Type: Conference abstract for conference - Conference abstract for conference

Presented at: European Congress of Chemical Engineering - 6, Copenhagen