Mads Hartvig Clausen

Mads Hartvig Clausen

Professor

DTU KEMI
Institut for Kemi

Kemi: Faculty
Organisk Kemi: Mads H. Clausen Group

Danmarks Tekniske Universitet

Kemitorvet 207

Bygning 206, rum 116

2800 Kgs. Lyngby

Tlf.
Mobil
Fax 45 93 39 68
E-mail mhc@kemi.dtu.dk
ORCID 0000-0001-9649-1729

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2019
 

EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology

Brennecke, Philip ; Rasina, Dace ; Aubi, Oscar ; Herzog, Katja ; Lanskron, Johannes ; Cautain, Bastien ; Vicente, Francisca ; Quintana, Jordi ; Stechmann, Bahne ; Brea, Jose ; Kolanowski, Jacek ; Pilarski, Radoslaw ; Orzaez, Mar ; Pienda-Lucena, Antonio ; Laraia, Luca ; Nami, Faranak ; Zielenkiewicz, Piotr ; Paruch, Kamil ; Hansen, Espen ; von Kries, Jens ; Neuenschwander, Martin ; Specker, Edgar ; Bartunek, Petr ; Simova, Sarka ; Lesinikowski, Zbigniew ; Krauss, Stefan ; Lëhtio, Lari ; Bilitewski, Ursula ; Broenstrup, Mark ; Tásken, Kjetil ; Lickert, Heiko ; Clausen, Mads Hartvig ; Andersen, Jeanette ; Vicent, Maria ; Genilloud, Olga ; Martinez, Aurora ; Nazaré, Marc ; Gribbon, Philip ; Fecke, Wolfgang
in: SLAS DISCOVERY: Advancing Life Sciences R&D, vol: 24, issue: 3, pages: 398-413

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1177/2472555218816276

 

Generation of a Heteropolycyclic and Sp3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/DielsAlder and ROM-RCM Reaction Sequence

Flagstad, Thomas ; Azevedo, Carlos ; Troelsen, Nikolaj Sten ; Min, Geanna ; Macé, Yohan ; Willaume, Anthony ; Guilleux, Rachel ; Velay, Mélanie ; Bonnet, Karine ; Morgentin, Rémy ; Nielsen, Thomas E. ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, vol: 2019, issue: 5, pages: 1061-1076

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1002/ejoc.201801551

 

Substrate specificity of novel GH16 endo-β-(1→3)-galactanases acting on linear and branched β-(1→3)-1 galactooligosaccharides

Kalomoiri, Panagiota ; Holck, Jesper ; Coulomb, Laure ; Boos, Irene ; Enemark-Rasmussen, Kasper ; Spodsberg, Nikolaj ; Monrad, Rune Nygaard ; Clausen, Mads Hartvig
in: Journal of Biotechnology, vol: 290, pages: 44-52

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1016/j.jbiotec.2018.12.006

2018
 

A Tomato Tocopherol Binding Protein Sheds Light on Intracellular α-tocopherol Metabolism in Plants

Bermúdez, Luisa ; del Pozo, Talía ; Lira, Bruno Silvestre ; de Godoy, Fabiana ; Boos, Irene ; Romanó, Cecilia ; Previtali, Viola ; Almeida, Juliana ; Bréhélin, Claire ; Asis, Ramón ; Quadrana, Leandro ; Demarco, Diego ; Alseekh, Saleh ; Salinas Gamboa, Rigel ; Pérez-Flores, Laura ; Dominguez, Pia Guadalupe ; Rothan, Christophe ; Fernie, Alisdair Robert ; González, Maurício ; Stocker, Achim ; Hemmerle, Andrea ; Clausen, Mads Hartving ; Carrari, Fernando ; Rossi, Magdalena
in: Plant and Cell Physiology, pages: 2188-2203

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1093/pcp/pcy191

  PDF

Bi-functional glycosyltransferases catalyze both extension and termination of pectic galactan oligosaccharides

Laursen, Tomas ; Stonebloom, Solomon H ; Pidatala, Venkataramana R ; Birdseye, Devon S ; Clausen, Mads H. ; Mortimer, Jenny C ; Scheller, Henrik Vibe
in: Plant Journal, vol: 94, issue: 2, pages: 340-351

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1111/tpj.13860

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Branched pectic galactan in phloem-sieve-element cell walls: implications for cell mechanics

Torode, Thomas A. ; O'Neill, Rachel E. ; Marcus, Susan E. ; Cornuault, Valérie ; Pose, Sara ; Lauder, Rebecca P. ; Kracun, Stjepan Kresimir ; Gro Rydahl, Maja ; Andersen, Mathias Christian Franch ; Willats, William G. T. ; Braybrook, Siobhan A. ; Townsend, Belinda J. ; Clausen, Mads Hartvig ; Knox, J. Paul
in: Plant Physiology, vol: 176, issue: 2, pages: 1547-1558

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1104/pp.17.01568

 

Injectable iodine-125 labeled tissue marker for radioactive localization of non-palpable breast lesions

Schaarup-Jensen, Henrik ; Jensen, Andreas Ingemann ; Hansen, Anders Elias ; El Ali, Henrik H. ; Hammershøj, Peter ; Jølck, Rasmus Irming ; Kjær, Andreas ; Andresen, Thomas Lars ; Clausen, Mads Hartvig
in: Acta Biomaterialia, vol: 65, pages: 197-202

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1016/j.actbio.2017.10.029

  PDF

Iridium Catalysis: Reductive Conversion of Glucan to Xylan

Pedersen, Martin Jæger ; Madsen, Robert ; Clausen, Mads Hartvig
in: Chemical Communications, vol: 54, issue: 8, pages: 952-955

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1039/C7CC09260A

 

Methotrexate Prodrugs Sensitive to Reactive Oxygen Species for the Improved Treatment of Rheumatoid Arthritis

Andersen, Nikolaj S. ; Peiro Cadahia, Jorge ; Previtali, Viola ; Bondebjerg, Jon ; Hansen, Christian A. ; Hansen, Anders E. ; Andresen, Thomas Lars ; Clausen, Mads H.
in: European Journal of Medicinal Chemistry, vol: 156, pages: 738-746

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1016/j.ejmech.2018.07.045

 

Petasis/Diels-Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production

Flagstad, Thomas ; Azevedo, Carlos M. G. ; Min, Geanna ; Willaume, Anthony ; Morgentin, Rémy ; Nielsen, Thomas E. ; Clausen, Mads H.
in: European Journal of Organic Chemistry, vol: 2018, issue: 36, pages: 5023-5029

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1002/ejoc.201800565

  PDF

Petasis/Diels-Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production (vol 2018, pg 5023, 2018)

Flagstad, Thomas ; Azevedo, Carlos M. G. ; Min, Geanna ; Willaume, Anthony ; Morgentin, Remy ; Nielsen, Thomas E. ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, vol: 2018, issue: 46, pages: 6596-6596

Type: Journal article

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1002/ejoc.201801730

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Remote loading of liposomes with a 124I-radioiodinated compound and their in vivo evaluation by PET/CT in a murine tumor model

Engudar, Gokce ; Schaarup-Jensen, Henrik ; Fliedner, Frederikke P. ; Hansen, Anders E. ; Kempen, Paul ; Jølck, Rasmus I. ; Kjær, Andreas ; Andresen, Thomas L. ; Clausen, Mads H. ; Jensen, Andreas Tue Ingemann ; Henriksen, Jonas Rosager
in: Theranostics, vol: 8, issue: 21, pages: 5828-5841

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.7150/thno.26706

 

Synthesis and Evaluation of Hydrogen Peroxide Sensitive Prodrugs of Methotrexate and Aminopterin for the Treatment of Rheumatoid Arthritis

Peiró Cadahía, Jorge ; Bondebjerg, Jon ; Hansen, Christian A. ; Previtali, Viola ; Hansen, Anders E. ; Andresen, Thomas L. ; Clausen, Mads Hartvig
in: Journal of Medicinal Chemistry, vol: 61, issue: 8, pages: 3503-3515

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1021/acs.jmedchem.7b01775

  PDF

Synthesis of branched and linear 1,4-linked galactan oligosaccharides

Andersen, Mathias C. Franch ; Boos, Irene ; Kinnaert, Christine ; Awan, Shahid Iqbal ; Pedersen, Henriette L. ; Kracun, Stjepan K ; Lanz, Gyrithe ; Rydahl, Maja G ; Kjærulff, Louise ; Håkansson, Maria ; Kimbung, Raymond ; Logan, Derek ; Gotfredsen, Charlotte Held ; Willats, William George Tycho ; Clausen, Mads Hartvig Hartvig
in: Organic and Biomolecular Chemistry, vol: 16, issue: 7, pages: 1157-1162

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1039/C7OB03035E

  PDF

Synthesis of Two Tetrasaccharide Pentenyl Glycosides Related to the Pectic Rhamnogalacturonan I Polysaccharide

Zakharova , Alexandra N. ; Awan, Shahid I. ; Nami, Faranak ; Gotfredsen, Charlotte Held ; Madsen, Robert ; Clausen, Mads H.
in: Molecules, vol: 23, issue: 2

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.3390/molecules23020327

 

The Three Members of the Arabidopsis thaliana Glycosyltransferase Family 92 are Functional β-1,4-Galactan Synthases

Ebert, Berit ; Birdseye, Devon ; Liwanag, April J. M. ; Laursen, Tomas ; Rennie, Emilie A. ; Guo, Xiaoyuan ; Catena, Michela ; Rautengarten, Carsten ; Stonebloom, Solomon H. ; Gluza, Pawel ; Pidatala, Venkataramana ; Andersen, Mathias Christian Franch ; Cheetamun, Roshan ; Mortimer, Jenny C. ; Heazlewood, Joshua L ; Bacic, Antony ; Clausen, Mads H. ; Willats, William G T ; Scheller, Henrik V.
in: Plant and Cell Physiology, vol: 59, issue: 12, pages: 2624-2636

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1093/pcp/pcy180

2017
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An efficient synthesis of linear β-(1→6)-galactan oligosaccharides related to plant cell wall glycans

Andersen, Mathias Christian Franch ; Arentoft, Camilla Anna Søholt ; Boos, Irene ; Kinnaert, Christine ; Awan, Shahid Iqbal ; Clausen, Mads Hartvig
in: Trends in Carbohydrate Research, vol: 9, issue: 2, pages: 27-37

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017

  PDF

A synthetic glycan microarray enables epitope mapping of plant cell wall glycan-directed antibodies

Ruprecht, Colin ; Bartetzko, Max P ; Senf, Deborah ; Dallabernardina, Pietro ; Boos, Irene ; Andersen, Mathias Christian Franch ; Kotake, Toshihisa ; Knox, J. Paul ; Hahn, Michael G. ; Clausen, Mads Hartvig ; Pfrengle, Fabian
in: Plant Physiology, vol: 175, issue: 3, pages: 1094-1104

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1104/pp.17.00737

  PDF

Chemical Synthesis of Oligosaccharides related to the Cell Walls of Plants and Algae

Kinnaert, Christine ; Daugaard, Mathilde ; Nami, Faranak ; Clausen, Mads Hartvig
in: Chemical Reviews, vol: 117, issue: 17, pages: 11337-11405

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1021/acs.chemrev.7b00162

 

Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

Hammershøj, Peter ; Thyhaug, Erling ; Harris, Pernille ; Ek, Pramod Kumar ; Andresen, Thomas Lars ; Clausen, Mads Hartvig
in: Tetrahedron Letters, vol: 58, issue: 16, pages: 1611-1615

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1016/j.tetlet.2017.03.028

 

Convergent strategy for the synthesis of S-linked oligoxylans

Bonora, Beatrice ; Boos, Irene ; Clausen, Mads Hartvig
in: Carbohydrate Research, pages: 53-57

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1016/j.carres.2017.03.016

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Diastereoselective Synthesis of Novel Heterocyclic Scaffolds through Tandem Petasis 3-Component/Intramolecular Diels-Alder and ROM-RCM Reactions

Ishøy, Mette ; Petersen, Rico ; Petersen, Michael Åxman ; Wu, Peng ; Clausen, Mads Hartvig ; Nielsen, Thomas Eiland
in: Chemical Communications, vol: 53, issue: 68, pages: 9410-9413

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1039/C7CC02948A

  PDF

Synthesis and application of branched type II arabinogalactans

Andersen, Mathias Christian Franch ; Boos, Irene ; Ruprecht, Colin ; Willats, William G. T. ; Pfrengle, Fabian ; Clausen, Mads Hartvig
in: Journal of Organic Chemistry, vol: 82, issue: 23, pages: 12066–12084

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1021/acs.joc.7b01796

 

Synthesis and formulation studies of griseofulvin analogues with improved solubility and metabolic stability

Petersen, Asger Bjørn ; Andersen, Nikolaj Sten ; Konotop, Gleb ; Hanafiah, Nur Hafzan Md ; Raab, Marc S. ; Krämer, Alwin ; Clausen, Mads Hartvig
in: European Journal of Medicinal Chemistry, vol: 130, pages: 240-247

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1016/j.ejmech.2017.02.055

2016
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A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

Wu, Peng ; Cohrt, Anders Emil O'Hanlon ; Petersen, Rico ; Morgentin, Rémy ; Lemoine, Hugues ; Roche, Carine ; Willaume, Anthony ; Clausen, Mads Hartvig ; Nielsen, Thomas Eiland
in: Organic & Biomolecular Chemistry, vol: 14, issue: 29, pages: 6947-6950

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1039/c6ob01148a

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Characterization of the LM5 pectic galactan epitope with synthetic analogues of β-1,4-d-galactotetraose

Andersen, Mathias Christian Franch ; Boos, Irene ; Marcus, Susan E. ; Kračun, Stjepan K. ; Rydahl, Maja Gro ; Willats, William G.T. ; Knox, J. Paul ; Clausen, Mads Hartvig
in: Carbohydrate Research, vol: 436, pages: 36–40

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1016/j.carres.2016.10.012

  PDF

Observations on the Influence of Precursor Conformations on Macrocyclization Reactions

Hammershøj, Peter ; Beldring, Klavs ; Nielsen, Anders R. ; Fristrup, Peter ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, vol: 2016, issue: 8, pages: 1533-1540

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1002/ejoc.201501445

 

Small-molecule kinase inhibitors: an analysis of FDA-approved drugs

Wu, Peng ; Nielsen, Thomas Eiland ; Clausen, Mads Hartvig
in: Drug Discovery Today, vol: 21, issue: 1, pages: 5–10

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1016/j.drudis.2015.07.008

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Strategies for improving the solubility and metabolic stability of griseofulvin analogues

Petersen, Asger Bjørn ; Konotop, G. ; Hanafiah, N. H. M. ; Hammershøj, Peter ; Raab, M. S. ; Kraemer, A. ; Clausen, Mads Hartvig
in: European Journal of Medicinal Chemistry, vol: 116, pages: 210-215

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1016/j.ejmech.2016.03.071

  PDF

Synthesis of sp3-rich scaffolds for molecular libraries through complexity-generating cascade reactions

Flagstad, Thomas ; Min, Geanna ; Bonnet, K. ; Morgentin, R. ; Roche, D. ; Clausen, Mads Hartvig ; Nielsen, Thomas Eiland
in: Organic & Biomolecular Chemistry, vol: 14, issue: 21, pages: 4943-4946

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1039/c6ob00961a

  PDF

Synthesis of β-1,4-Linked Galactan Side-Chains of Rhamnogalacturonan I

Andersen, Mathias Christian Franch ; Kracun, Stjepan ; Rydahl, Maja ; Willats, William ; Clausen, Mads Hartvig
in: Chemistry: A European Journal, vol: 22, issue: 33, pages: 11543-11548

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1002/chem.201602197

  PDF

Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

Wu, Peng ; Petersen, Michael Åxman ; Petersen, Rico ; Flagstad, Thomas ; Guilleux, Rachel ; Ohsten Rasmussen, Martin ; Morgentin, Rémy ; Nielsen, Thomas Eiland ; Clausen, Mads Hartvig
in: RSC Advances, vol: 2016, issue: 6, pages: 46654-46657

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1039/C6RA08786H

2015
 

A hydrogel based nanosensor with an unprecedented broad sensitivity range for pH measurements in cellular compartments

Zhang, M. ; Søndergaard, Rikke Vicki ; Ek, Pramod Kumar ; Henriksen, Jonas Rosager ; Cui, D. ; Hammershøj, Peter ; Clausen, Mads Hartvig ; Andresen, Thomas Lars
in: Analyst, vol: 140, pages: 7246-7253

Type: Journal article (Peer reviewed)

Status: E-pub ahead of print     |    År: 2015     |    DOI: https://doi.org/10.1039/c5an01014d

  PDF

Allosteric small-molecule kinase inhibitors

Wu, Peng ; Clausen, Mads Hartvig ; Nielsen, Thomas E.
in: Pharmacology & Therapeutics, vol: 156, pages: 56-68

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1016/j.pharmthera.2015.10.002

 

Facile Large-Scale Synthesis of 5- and 6-Carboxyfluoresceins

Hammershøj, Peter ; Ek, Pramod Kumar ; Harris, Pernille ; Andresen, Thomas Lars ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, vol: 2015, issue: 33, pages: 7301-7309

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1002/ejoc.201501013

  PDF

FDA-approved small-molecule kinase inhibitors

Wu, Peng ; Nielsen, Thomas E. ; Clausen, Mads Hartvig
in: Trends in Pharmacological Sciences, vol: 36, issue: 7, pages: 422-439

Type: Journal article (Peer reviewed)

Status: E-pub ahead of print     |    År: 2015     |    DOI: https://doi.org/10.1016/j.tips.2015.04.005

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Injectable Colloidal Gold for Use in Intrafractional 2D Image-Guided Radiation Therapy

Jølck, Rasmus Irming ; Rydhog, Jonas S. ; Christensen, Anders Nymark ; Hansen, Anders Elias ; Bruun, Linda Maria ; Schaarup-Jensen, Henrik ; von Wenck, Asger Stevner ; Borresen, Betina ; Kristensen, Annemarie T. ; Clausen, Mads Hartvig ; Kjær, Andreas ; Conradsen, Knut ; Larsen, Rasmus ; af Rosenschold, Per Munck ; Andresen, Thomas Lars
in: Advanced Healthcare Materials, vol: 4, issue: 6, pages: 856-863

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1002/adhm.201400651

  PDF

Reductive Cyclization and Petasis‐Like Reaction for the Synthesis of Functionalized γ‐Lactams

Wu, Peng ; Petersen, Michael Åxman ; Cohrt, A. Emil ; Petersen, Rico ; Clausen, Mads Hartvig ; Nielsen, Thomas Eiland
in: European Journal of Organic Chemistry, vol: 2015, issue: 11, pages: 2346-2350

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1002/ejoc.201500143

 

Synthesis of 1,4,5 trisubstituted γ-lactams via a 3-component cascade reaction

Petersen, Michael Åxman ; Mortensen, Michael Agerup ; Cohrt, A. Emil ; Petersen, Rico ; Wu, Peng ; Fleury-Brégeot, Nicolas ; Morgentin, Rémy ; Lardy, Claude ; Nielsen, Thomas Eiland ; Clausen, Mads Hartvig
in: Bioorganic & Medicinal Chemistry, vol: 23, issue: 11, pages: 2695-2698

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2015     |    DOI: https://doi.org/10.1016/j.bmc.2015.01.041

 

Synthesis of (Arylamido)pyrrolidinone Libraries through Ritter-Type Cascade Reactions of Dihydroxylactams

Wu, Peng ; Petersen, Michael Åxman ; Petersen, Rico ; Ohsten Rasmussen, Martin ; Bonnet, Karine ; Nielsen, Thomas Eiland ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, vol: 2015, issue: 25, pages: 5633-5639

Type: Journal article (Peer reviewed)

Status: E-pub ahead of print     |    År: 2015     |    DOI: https://doi.org/10.1002/ejoc.201500712

2014
 

Distinct substrate specificities of three glycoside hydrolase family 42 β-galactosidases from Bifidobacterium longum subsp. infantis ATCC 15697

Viborg, Alexander Holm ; Katayama, Takane ; Abou Hachem, Maher ; Andersen, Mathias Christian Franch ; Nishimoto, Mamoru ; Clausen, Mads Hartvig ; Urashima, Tadasu ; Svensson, Birte ; Kitaoka, Motomitsu
in: Glycobiology, vol: 24, issue: 2, pages: 208-216

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: https://doi.org/10.1093/glycob/cwt104

 

Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.

Viart, Helene Marie-France ; Larsen, T. S. ; Tassone, Chiara ; Andresen, Thomas Lars ; Clausen, Mads Hartvig
in: Chemical Communications, vol: 50, issue: 58, pages: 7800-7802

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: https://doi.org/10.1039/c4cc00863d

  PDF

The Chemistry of Griseofulvin

Petersen, Asger Bjørn ; Rønnest, Mads Holger ; Larsen, Thomas Ostenfeld ; Clausen, Mads Hartvig
in: Chemical Reviews, vol: 114, issue: 24, pages: 12088-12107

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: https://doi.org/10.1021/cr400368e

 

Tomato Cutin Deficient 1 (CD1) and putative orthologs comprise an ancient family of cutin synthase‐like (CUS) proteins that are conserved among land plants

Yeats, Trevor H. ; Huang, Wenlin ; Chatterjee, Subhasish ; Viart, Helene Marie-France ; Clausen, Mads Hartvig ; Stark, Ruth E. ; Rose, Jocelyn K.C.
in: Plant Journal, vol: 77, issue: 5, pages: 667-675

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: https://doi.org/10.1111/tpj.12422

 

Tracking developmentally regulated post-synthetic processing of homogalacturonan and chitin using reciprocal oligosaccharide probes.

Mravec, Jozef ; Kračun, Stjepan K. ; Rydahl, Maja G. ; Westereng, Bjørge ; Miart, Fabien ; Clausen, Mads Hartvig ; Fangel, Jonatan U. ; Daugaard, Mathilde ; Van Cutsem, Pierre ; De Fine Licht, Henrik H. ; Höfte, Herman ; Malinovsky, Frederikke G. ; Domozych, David S. ; Willats, William G. T.
in: Development, vol: 141, issue: 24, pages: 4841-4850

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: https://doi.org/10.1242/dev.113365

2013
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A Mild Method for Regioselective Labeling of Aromatics with Radioactive Iodine

Rønnest, Mads Holger ; Nissen, Felix ; Pedersen, Palle Jacob ; Larsen, Thomas Ostenfeld ; Mier, Walter ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, vol: 2013, issue: 19, pages: 3970-3973

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2013     |    DOI: https://doi.org/10.1002/ejoc.201300419

 

Synthesis of a Backbone Hexasaccharide Fragment of the Pectic Polysaccharide Rhamnogalacturonan I

Zakharova, Alexandra N. ; Madsen, Robert ; Clausen, Mads H.
in: Organic Letters, vol: 15, issue: 8, pages: 201826-1829

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2013     |    DOI: https://doi.org/10.1021/ol400430p

2012
 

Carbohydrate Microarrays in Plant Science

Fangel, Jonatan Ulrik ; Pedersen, H.L. ; Vidal-Melgosa, S. ; Ahl, Louise Isager ; Salmean, A.A. ; Egelund, Jack ; Rydahl, Maja Gro ; Clausen, M.H. ; Willats, William George Tycho
in: Methods in Molecular Biology, vol: 918, pages: 351-362

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2012     |    DOI: https://doi.org/10.1007/978-1-61779-995-2_19

  PDF

Disparate SAR Data of Griseofulvin Analogues for the Dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 Cancer Cells

Rønnest, Mads Holger ; Raab, Marc S. ; Anderhub, Simon ; Boesen, Sven ; Krämer, Alwin ; Larsen, Thomas Ostenfeld ; Clausen, Mads Hartvig
in: Journal of Medicinal Chemistry, vol: 55, issue: 2, pages: 652-660

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2012     |    DOI: https://doi.org/10.1021/jm200835c

 

GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo

Raab, Marc S. ; Breitkreutz, Iris ; Anderhub, Simon ; Rønnest, Mads Holger ; Leber, Blanka ; Larsen, Thomas Ostenfeld ; Weiz, Ludmila ; Konotop, Gleb ; Hayden, Patrick J. ; Podar, Klaus ; Fruehauf, Johannes ; Nissen, Felix ; Mier, Walter ; Haberkorn, Uwe ; Ho, Anthony D. ; Goldschmidt, Hartmut ; Anderson, Kenneth C. ; Clausen, Mads Hartvig ; Krämer, Alwin
in: Cancer Research, vol: 72, issue: 20, pages: 5374-5385

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2012     |    DOI: https://doi.org/10.1158/0008-5472.CAN-12-2026

 

Pectin Biosynthesis: GALS1 in Arabidopsis thaliana Is a β-1,4-Galactan β-1,4-Galactosyltransferase [C][W][OA]

Liwanag, April Jennifer Madrid ; Ebert, Berit ; Verhertbruggen, Yves ; Rennie, Emilie A. ; Rautengarten, Carsten ; Oikawa, Ai ; Andersen, Mathias Christian Franch ; Clausen, Mads Hartvig ; Scheller, Henrik
in: Plant Cell, vol: 24, issue: 12, pages: 5024-5036

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2012     |    DOI: https://doi.org/10.1105/tpc.112.106625

 

Synthesis and Stability Studies of α,α‐Difluoro Ester Phospholipids

Pedersen, Palle Jacob ; Andresen, Thomas Lars ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, vol: 2012, issue: 33, pages: 6656-6661

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2012     |    DOI: https://doi.org/10.1002/ejoc.201200565

 

Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A2 activity

Pedersen, Palle Jacob ; Viart, Helene Marie-France ; Melander, Fredrik ; Andresen, Thomas Lars ; Madsen, Robert ; Clausen, Mads Hartvig
in: Bioorganic & Medicinal Chemistry, vol: 20, issue: 13, pages: 3972-3978

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2012     |    DOI: https://doi.org/10.1016/j.bmc.2012.05.024

 

The identification of cutin synthase: formation of the plant polyester cutin

Yeats, Trevor H. ; Martin, Laetitia B. B. ; Viart, Helene Marie-France ; Isaacson, Tal ; He, Yonghua ; Zhao, Lingxia ; Matas, Antonio J. ; Buda, Gregory J. ; Domozych, David S. ; Clausen, Mads Hartvig ; Rose, Jocelyn K. C.
in: Nature Chemical Biology, vol: 8, issue: 7, pages: 609-611

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2012     |    DOI: https://doi.org/10.1038/NCHEMBIO.960

 

Versatile High Resolution Oligosaccharide Microarrays for Plant Glycobiology and Cell Wall Research

Pedersen, Henriette Lodberg ; Fangel, Jonatan Ulrik ; McCleary, Barry ; Ruzanski, Christian ; Rydahl, Maja Gro ; Ralet, Marie-Christine ; Farkas, Vladimir ; von Schantz, Laura ; Marcus, Susan E. ; Andersen, Mathias Christian Franch ; Field, Rob ; Ohlin, Mats ; Knox, J. Paul ; Clausen, Mads Hartvig ; Willats, William George Tycho
in: Journal of Biological Chemistry, vol: 287, issue: 47, pages: 39429-39438

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2012     |    DOI: https://doi.org/10.1074/jbc.M112.396598

2011
 

Biologically Active Macrocyclic Compounds – from Natural Products to Diversity‐Oriented Synthesis

Madsen, Charlotte Marie ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, vol: 2011, issue: 17, pages: 3107-3115

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2011     |    DOI: https://doi.org/10.1002/ejoc.201001715

  PDF

(+)-Geodin from Aspergillus terreus.

Rønnest, Mads Holger ; Nielsen, Morten Thrane ; Leber, Blanka ; Mortensen, Uffe Hasbro ; Krämer, Alwin ; Clausen, Mads Hartvig ; Larsen, Thomas Ostenfeld ; Harris, Pernille
in: Acta Crystallographica. Section C: Crystal Structure Communications, vol: 67, issue: Pt 3, pages: o125-o128

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2011     |    DOI: https://doi.org/10.1107/S0108270111005816

  PDF

Lipid conjugated prodrugs for enzyme-triggered liposomal drug delivery to tumors

Clausen, Mads Hartvig
in: American Chemical Society. Abstracts of Papers (at the National Meeting), vol: 242, pages: MEDI 20
Presented at:
242nd National Meeting of the American-Chemical-Society (ACS)

Type: Conference article (Peer reviewed)

Status: Published     |    År: 2011

 

Selective Acylation Enhances Membrane Charge Sensitivity of the Antimicrobial Peptide Mastoparan-X

Etzerodt, Thomas Povl ; Henriksen, Jonas Rosager ; Rasmussen, Palle ; Clausen, Mads Hartvig ; Andresen, Thomas Lars
in: Biophysical Journal, vol: 100, issue: 2, pages: 399-409

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2011     |    DOI: https://doi.org/10.1016/j.bpj.2010.11.040

 

Synthesis and application of plant cell wall oligosaccharides

Clausen, Mads Hartvig
in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol: 242, pages: -
Presented at:
242nd National Meeting of the American-Chemical-Society (ACS)

Type: Conference article (Peer reviewed)

Status: Published     |    År: 2011

  PDF

Synthesis and structure-activity relationship of liposomal substrates for phospholipase A(2)

Viart, Helene Marie-France ; Clausen, Mads Hartvig
in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol: 242, pages: MEDI 344
Presented at:
242nd National Meeting of the American-Chemical-Society (ACS)

Type: Conference article (Peer reviewed)

Status: Published     |    År: 2011

2010
 

Isomerization of all-(E)-Retinoic Acid Mediated by Carbodiimide Activation - Synthesis of ATRA Ether Lipid Conjugates

Christensen, Mikkel Stochkendahl ; Pedersen, Palle Jacob ; Andresen, Thomas Lars ; Madsen, Robert ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, issue: 4, pages: 719-724

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2010     |    DOI: https://doi.org/10.1002/ejoc.200901128

 

Liposomal Formulation of Retinoids Designed for Enzyme Triggered Release

Pedersen, Palle Jacob ; Adolph, Sidsel Kramshøj ; Subramanian, Arun Kumar ; Arouri, A. ; Andresen, Thomas Lars ; Mouritsen, O.G. ; Madsen, Robert ; Madsen, M.W. ; Peters, Günther H.J. ; Clausen, Mads Hartvig
in: Journal of Medicinal Chemistry, vol: 53, issue: 9, pages: 3782-3792

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2010     |    DOI: https://doi.org/10.1021/jm100190c

 

Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties

Pedersen, Palle Jacob ; Adolph, Sidsel K. ; Andresen, Thomas Lars ; Madsen, Mogens W. ; Madsen, Robert ; Clausen, Mads Hartvig
in: Bioorganic & Medicinal Chemistry Letters, vol: 20, issue: 15, pages: 4456-4458

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2010     |    DOI: https://doi.org/10.1016/j.bmcl.2010.06.054

 

Structural Insights into Substrate Specificity and the anti beta-Elimination Mechanism of Pectate Lyase

Seyedarabi, A. ; To, T.T. ; Ali, S. ; Hussain, S. ; Fries, M. ; Madsen, Robert ; Clausen, Mads Hartvig ; Teixteira, S. ; Brocklehurst, K. ; Pickersgill, R.W.
in: Biochemistry, vol: 49, issue: 3, pages: 539-546

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2010     |    DOI: https://doi.org/10.1021/bi901503g

 

Synthesis and single crystal X-ray analysis of two griseofulvin metabolites

Rønnest, Mads Holger ; Harris, Pernille ; Gotfredsen, Charlotte Held ; Larsen, T.O. ; Clausen, Mads Hartvig
in: Tetrahedron Letters, vol: 51, issue: 45, pages: 5881-5882

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2010     |    DOI: https://doi.org/10.1016/j.tetlet.2010.08.095

 

Synthesis of new diverse macrocycles from diol precursors

Madsen, Charlotte Marie ; Hansen, Martin ; Thrane, Marie V. ; Clausen, Mads Hartvig
in: Tetrahedron, vol: 66, issue: 52, pages: 9849-9859

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2010     |    DOI: https://doi.org/10.1016/j.tet.2010.10.071

2009
 

Rapid synthesis of macrocycles from diol precursors

Wingstrand, Magnus ; Madsen, Charlotte Marie ; Clausen, Mads Hartvig
in: Tetrahedron Letters, vol: 50, issue: 6, pages: 693-695

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2009     |    DOI: https://doi.org/10.1016/j.tetlet.2008.11.100

 

Synthesis and Biophysical Characterization of Chlorambucil Anticancer Ether Lipid Prodrugs

Pedersen, Palle Jacob ; Christensen, Mikkel Stochkendahl ; Ruysschaert, Tristan ; Linderoth, Lars ; Andresen, Thomas Lars ; Melander, Fredrik ; Mouritsen, Ole G. ; Madsen, Robert ; Clausen, Mads Hartvig
in: Journal of Medicinal Chemistry, vol: 52, issue: 10, pages: 3408-3415

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2009     |    DOI: https://doi.org/10.1021/jm900091h

 

Synthesis and Structure-Activity Relationship of Griseofulvin Analogues as Inhibitors of Centrosomal Clustering in Cancer Cells

Rønnest, Mads Holger ; Rebacz, Blanka ; Markworth, Lene ; Terp, Anette Hinsch ; Larsen, Thomas Ostenfeld ; Krämer, A. ; Clausen, Mads Hartvig
in: Journal of Medicinal Chemistry, vol: 52, issue: 10, pages: 3342-3347

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2009     |    DOI: https://doi.org/10.1021/jm801517j

2008
 

Regio- and stereoselective hydrosilylation of immobilized terminal alkynes

Pedersen, Palle Jacob ; Henriksen, Jonas ; Gotfredsen, Charlotte Held ; Clausen, Mads Hartvig
in: Tetrahedron Letters, vol: 49, issue: 43, pages: 6220-6223

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2008     |    DOI: https://doi.org/10.1016/j.tetlet.2008.08.043

 

Structural characterization of homogalacturonan by NMR spectroscopy - assignment of reference compounds

Petersen, Bent O. ; Meier, Sebastian ; Duus, Jens Øllgaard ; Clausen, Mads Hartvig
in: Carbohydrate Research, vol: 343, issue: 16, pages: 2830-2833

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2008     |    DOI: https://doi.org/10.1016/j.carres.2008.08.016

2007
 

Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen.

Rebacz, B. ; Larsen, Thomas Ostenfeld ; Clausen, Mads Hartvig ; Rønnest, Mads Holger ; Löffler, H. ; Ho, A.D. ; Krämer, A.
in: Cancer Research, issue: 67, pages: 6342-6350

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2007     |    DOI: https://doi.org/10.1158/0008-5472.CAN-07-0663

 

Study of the mode of action of a polygalacturonase from the phytopathogen Burkholderia cepacia

Massa, C. ; Clausen, Mads Hartvig ; Stojan, J. ; Lamba, D. ; Campa, C.
in: Biochemical Journal, vol: 407, pages: 207-217

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2007     |    DOI: https://doi.org/10.1042/BJ20061833

2004
 

A monoclonal antibody to feruloylated (1→4)-β-D-galactan

Clausen, Mads Hartvig ; Ralet, Marie-Christine ; Willats, William G. T. ; McCartney, Lesley ; Marcus, Susan E. ; Thibault, Jean-François ; Knox, J. Paul
in: Planta, vol: 219, issue: 6, pages: 1036-1041

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2004     |    DOI: https://doi.org/10.1007/s00425-004-1309-3

 

Synthesis of oligogalacturonates conjugated to BSA

Clausen, Mads Hartvig ; Madsen, Robert
in: Carbohydrate Research, vol: 339, issue: 13, pages: 2159-2169

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2004

2003
 

Synthesis of Hexasaccharide Fragments of Pectin

Clausen, Mads Hartvig ; Madsen, Robert
in: Chemistry - A European Journal, vol: 9, issue: 16, pages: 3821-3832

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2003

 

Synthetic methyl hexagalacturonate hapten inhibitors of antihomogalacturonan monoclonal antibodies LM7, JIM5 and JIM7

Clausen, Mads Hartvig ; Willats, William George Tycho ; Knox, J. Paul
in: Carbohydrate Research, vol: 338, issue: 17, pages: 1797-1800

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2003     |    DOI: https://doi.org/10.1016/S0008-6215(03)00272-6

2001
 

A strategy for chemical synthesis of selectively methyl-esterified oligomers of galacturonic acid

Clausen, Mads Hartvig ; Jørgensen, Malene Ryborg ; Thorsen, Jesper ; Madsen, Robert
in: Royal Chemical Society. Journal. Perkin Transactions 1, vol: 1, issue: 5, pages: 543-551

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2001