My field of research is toxic and essential trace elements and
their metabolites in food, in relation to health and disease. The
chemical analysis of trace elements and their species in food and
human samples has been studied using coupled techniques, including
HPLC-mass spectrometry. Recently, detection of nanoparticles in
biological samples has been studied by field flow fractionation
with detection by light scattering and mass spectrometry.
Food monitoring data and estimation of intake of toxic or essential
trace elements from constitute a valuable point of reference for
evaluation of food safety, partially due to the impact of
environmental contamination by heavy metals.
Human research projects include identification of biomarkers of
intake of selenium in samples from intervention trials and
application of isotope-specific analyses for estimation of
The essential minerals are micronutrients that prevent deficiency
diseases. The possible sub-optimum intake of an essential mineral
via the diet is the primary criterion for initiation of research
activities on e.g. selenium and iodine. The research aims to
clarify which molecular forms (species) of minerals that occurs in
food and to differentiate their biological effects. Detailed
knowledge of occurring molecular forms of a mineral is necessary
for evaluation of its nutritional value.
Finally, biological monitoring of toxic and essential trace
elements in blood, urine and faeces may provide additional
information on the nutritional impact, fate and excretion from the
human body. Such measurements are often conducted by
chromatographic separation techniques coupled with inductively
coupled plasma mass spectrometry (ICP-MS).