Erik Huusfeldt Larsen

Erik Huusfeldt Larsen

Head of Research Group, Senior Researcher

National Food Institute, Technical University of Denmark

Research Group for Nano-Bio Science

Technical University of Denmark

Mørkhøj Bygade 19

Building B, room 227A

2860 Søborg

Fax +45 35 88 74 48
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Keywords Sygdom

My field of research is toxic and essential trace elements and their metabolites in food, in relation to health and disease. The chemical analysis of trace elements and their species in food and human samples has been studied using coupled techniques, including HPLC-mass spectrometry. Recently, detection of nanoparticles in biological samples has been studied by field flow fractionation with detection by light scattering and mass spectrometry.

Food monitoring data and estimation of intake of toxic or essential trace elements from constitute a valuable point of reference for evaluation of food safety, partially due to the impact of environmental contamination by heavy metals.

Human research projects include identification of biomarkers of intake of selenium in samples from intervention trials and application of isotope-specific analyses for estimation of bioavailability.

The essential minerals are micronutrients that prevent deficiency diseases. The possible sub-optimum intake of an essential mineral via the diet is the primary criterion for initiation of research activities on e.g. selenium and iodine. The research aims to clarify which molecular forms (species) of minerals that occurs in food and to differentiate their biological effects. Detailed knowledge of occurring molecular forms of a mineral is necessary for evaluation of its nutritional value.

Finally, biological monitoring of toxic and essential trace elements in blood, urine and faeces may provide additional information on the nutritional impact, fate and excretion from the human body. Such measurements are often conducted by chromatographic separation techniques coupled with inductively coupled plasma mass spectrometry (ICP-MS).