Aspergillus niger, fermentation, morphology
Topic of thesis: Particle size investigation of
Aspergillus niger pelleting behavior: causes and
consequences for industrial fermentation
Starting date: November 2013
Background: M.Sc. equivalent (German
“Diplom”) in Biotechnology, Technische Universität
Supervisors: Krist V. Gernaey, Ulrich Krühne,
Stuart M. Stocks
The aim of this project is to track the Aspergillus
niger biomass behaviour, beginning with spores and up to fully
mature biomass. With manipulations of the fungus’
(fermentation) environment in terms of ion strength, pH value and
mechanical power input by agitation as well as aeration and back
pressure, it is intended to create specific biomass configurations
– pelletous, mycelial and states between. Ideally, a model
can predict the broth’s rheology in order to keep the OTR in
the fermentation at the desired/highest possible level.
An outstanding trait of this project is the tight collaboration
with Novozymes which enables knowledge fusion with industrial data.
Ideally, the question of how important the morphology is for
productivity in an industrial strain can be answered.