Arun Kumar Somavarapu

Arun Kumar Somavarapu

PhD student

DTU CHEMISTRY
Department of Chemistry

Technical University of Denmark

Kemitorvet

Building 206, room 202

2800 Kgs. Lyngby

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2017
 

Membrane dynamics of γ-secretase provides a molecular basis for Aβ binding and processing

Somavarapu, Arun Kumar ; Kepp, Kasper Planeta
in journal: ACS Chemical Neuroscience (ISSN: 1948-7193) (DOI: http://dx.doi.org/10.1021/acschemneuro.7b00208), 2017

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2017     |    DOI: http://dx.doi.org/10.1021/acschemneuro.7b00208

 

The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu2+ -Aβ Complex

Somavarapu, Arun Kumar ; Shen, Fei ; Teilum, Kaare ; Zhang, Jingdong ; Mossin, Susanne ; Thulstrup, Peter W. ; Bjerrum, Morten J. ; Tiwari, Manish K. ; Szunyogh, Daniel ; Søtofte, Peter M. ; Kepp, Kasper Planeta ; Hemmingsen, Lars
in journal: Chemistry: A European Journal (ISSN: 0947-6539) (DOI: http://dx.doi.org/10.1002/chem.201703440), 2017

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2017     |    DOI: http://dx.doi.org/10.1002/chem.201703440

2016
 

Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's Disease

Somavarapu, Arun Kumar ; Kepp, Kasper Planeta
in journal: Journal of Neurochemistry (ISSN: 0022-3042) (DOI: http://dx.doi.org/10.1111/jnc.13535), vol: 137, issue: 1, pages: 101-111, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1111/jnc.13535

 

The dynamic mechanism of presenilin-function: Sensitive gate dynamics and loop unplugging control protein access

Somavarapu, Arun Kumar ; Kepp, Kasper Planeta
in journal: Neurobiology of Disease (ISSN: 0969-9961) (DOI: http://dx.doi.org/10.1016/j.nbd.2016.02.008), vol: 89, pages: 147-156, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1016/j.nbd.2016.02.008

2015
 

The Dependence of Amyloid‐β Dynamics on Protein Force Fields and Water Models

Somavarapu, Arun Kumar ; Kepp, Kasper Planeta
in journal: ChemPhysChem (ISSN: 1439-4235) (DOI: http://dx.doi.org/10.1002/cphc.201500415), vol: 16, issue: 15, pages: 3278-3289, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1002/cphc.201500415

 

Direct Correlation of Cell Toxicity to Conformational Ensembles of Genetic Aβ Variants

Somavarapu, Arun Kumar ; Kepp, Kasper Planeta
in journal: ACS Chemical Neuroscience (ISSN: 1948-7193) (DOI: http://dx.doi.org/10.1021/acschemneuro.5b00238), vol: 6, issue: 12, pages: 1990-1996, 2015

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: http://dx.doi.org/10.1021/acschemneuro.5b00238