Assistant Professor in T Cell Recognition in Relation to Epigenetic Modulation in Cancer

DTU Nanotech
Wednesday 07 Nov 18

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DTU Nanotech, Technical University of Denmark invites applications for a position as Assistant Professor in T Cell Recognition in Relation to Epigenetic Modulation in Cancer within the Biology and Chemistry section. The assistant professorship is a permanent entry-level faculty position.

The Section for Biology and Chemistry consists of 15 research groups and approx. 150 people working within the areas of immune regulation and recognition, drug delivery, bioimaging, artificial tissue and cells, nano particles, sensors, diagnostic methods among others.

The position is available in the ‘T cells and Cancer’ group headed by Professor Sine Reker Hadrup. 

The ‘T cell recognition and Cancer’ group is currently consisting of 25-30 people, including Postdocs, PhD students, Technicians and undergraduate students. The overall aim of the research group is to gain novel insight to T cell recognition of cancer and autoimmune diseases, through use and development of novel technologies. The primary aim of the current position is to determine the T cell recognition of cancer cells under influence of epigenetic modulation.

Responsibilities and tasks 
The assistant professor will be responsible for a line of research focussing on T cell recognition and immune activation in general toward cancer cells under influence of epigenetic modulations Epigenetic modulation may open the epitope landscape by increased expression of antigens normally tightly regulated through epigenetic silencing. Among such antigens are human endogenous retroviruses (HERV) that comprises up to 8% of the human genome. 

Specific aims to be addressed: 

  • Identification of T cells specific to HERV derived antigens and assessment of epigenetic therapy (DNMTi) induced contribution of such antigens.
  • Characterization of HERV specific T cells for therapeutic application 
  • Assessment of HERV specific T cells during combination therapy of DNMTi and checkpoint inhibitors 

To fulfil these aims the assistant professor will make use of a combination of multicolour flow cytometry and advanced the strategies for detection of antigen specific T cells using DNA barcode labelled MHC multimers. 

The assistant professor will be responsible for leading the project, ensuring progress, planning and excecuting the experimental work. In addition to the project specific aims, the assistant professor is expected to contribute to the MHC multimer-based technology – to improve the technology platform, optimize the workflow and improve the application strategies. Furthermore, the assistant professor will be responsible for the daily supervision of master and PhD students working on projects within this area. 

Furthermore, teaching on immune-related topic will be required, and the candidate should participate in teaching and learning programme. For international candidates, DTU offers Danish language courses for the purpose of being able to teach in Danish within the first 2-3 years.

Collaboration
The project is collaboration with the American Association for Cancer Research, and their stand-up-to-cancer (SU2C) funding programme. The position is funded in part by the SU2C epigenetic dream team and the Van Andel research institute. 

Contact and collaboration to the SU2C epigenetic dream team is an important component for the current position.

In general, collaborations, both internally and externally, are a key component of the research group and this line of collaborative efforts should be supported.

Qualifications
Candidates must hold a PhD degree (or equivalent).

The applicant must have experience in the field of T cell immunology, cancer biology, tumor immunology and use of MHC-multimers for T cell detection. Preferably, direct experience and expertise from working with DNA-barcode tagged MHC multimer libraries is essential. Also, the candidate most have in-depth understanding of MHC class I and II immunology, protein folding and expression strategies, and the use of MHC molecules in T cell assays.

The applicant must have experienced with multicolor flow cytometry and cell sorting.

The applicant must have experienced in project supervision and supervision of master students. Furthermore, the applicant must have experience with PCR, cell culturing, and specifically T cell culturing.   

Experience with the following is essential: 

  • MHC presentation
  • Building of large library screens using MHC multimers
  • DNA barcode use and design
  • Technology development of novel reagents for T cell analyses
  • T cell expansion
  • Flow cytometry
  • Supervision of students

Personal qualifications 

  • Dedication and flexibility
  • Team player, yet with an independent project focus
  • Working in an international environment
  • Take responsibilities beyond your individual project
  • You are driven by pushing boundaries
  • You enjoy working with complex topics

We offer high-level research environment and expertise in the relevant field and large research network.

Assessment
In the assessment of the candidates, consideration will be given to: 

  • Experience and quality of teaching 
  • Research experience 
  • Research vision and potential
  • Societal impact
  • Documented innovation activities, including commercialization and collaboration with industry
  • International experience
  • Internal and external collaboration
  • Communication skills

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

An assistant professorship is a permanent entry-level faculty position. After a maximum of 4 years, an assistant professor can be promoted to an associate professor position after assessment. More information can be found here: Career paths at DTU.   

Further information 
Further information may be obtained from Professor Sine Reker Hadrup, Mobile # +45 2712 5221

You can read more about DTU Nanotech at www.nanotech.dtu.dk/english.   

Application procedure 
Please submit your online application no later than 21 November 2018 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include: 

  • Application (cover letter)
  • CV
  • Teaching and research statement, with a focus on the “Assessment” bullet points listed above
  • Documentation of previous teaching and research, as related to the “Assessment” bullet points listed above
  • List of publications
  • H-index, and ORCID (see e.g. http://orcid.org/)
  • Diploma (MSc/PhD)
Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. 

DTU Nanotech, the Department of Micro-and Nanotechnology, is situated in the northern part of Copenhagen. DTU Nanotech is a center of excellence in micro-and nanotechnology utilizing sciences across the traditional boundaries of technology, thereby enabling innovative solutions for the benefit of society. DTU Nanotech has approx. 220 staff members with 40 % international employees, hence, the department constitutes an international environment.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.