Fermentation Engineer

Center for Biosustainability
torsdag 04 okt 18

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Frist 21. oktober 2018
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Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain) in Kongens Lyngby, close to Copenhagen, is building a scale-up/-down piloting facility to commercialize bio-based products and molecules for a variety of customers and application markets. The work of the Piloting Facility of the Center aims towards bridging the gap between academic metabolic engineering projects from cell factories and their commercial application. We aim at establishment and integration of a whole workflow, from synthetic biology through genetic engineering, bench-scale fermentations and scale-up process design towards gate milestone driven project and process development until successful release into the market.

To achieve that, we are using state-of-the-art technology, equipment and tools and seek fellow mindsets for open, creative, collaborative and interdisciplinary approaches. In order to accelerate time to market for the several organisms and cell hosts and their respective downstream processes, we intend to further strengthen the Centers already existing capabilities by adding a highly motivated team of Engineers, Scientists and Technicians to tackle this challenging task. An open mind for different disciplines in natural sciences and engineering is wanted, in order to learn the most of each other and create the critical synergies to be successful.

If you identify yourself with such a mindset, are interested to transition multiple organisms from micro-scale through bench-scale into multi-kilo scale, advance the processes further into commercialization through contract manufacturing, spin-outs, sales and licensing, and have confidence and enthusiasm for the bio-based economy, as we have, you should apply.

The ideal candidate is knowledgeable about microbial fermentation and process development and is used to work in bench-scale and 30-50L scale fermentation skids. Experience with larger Bioreactors is highly welcome. Organism engineers, molecular and microbiology researchers and chemical engineers work hand in hand with you to fulfill the mission of the facility. You are responsible to develop together with the team, techno-economic analyses and Key Performance Indicators of the process and return guidance and feedback to the research and development staff of the Center.

As a Fermentation Engineer, your position requires collaboration with internal research groups, the analytical and genome engineering group as well as with third parties, vendors, technology providers and engineering disciplines for process development. Also we ask you to drive the development across multiple organisms on the upstream (bio-reaction) side and assist more junior team members.

Responsibilities and tasks
  • Leading the transfer of cell factories, hosts and strains as well as bioprocesses through internal gate milestones
  • Collaborate with teams for performance mapping of small- and large-scale bio-reaction and verify specification demands
  • Collaborate with chemical and process engineers to integrate downstream separation and purification processes
  • Running, controlling and maintaining batch, fed-batch, repeated batch cultivations ideally for both bacteria and yeast, anaerobic and aerobic
  • Interpreting data obtained during and after fermentation processes and develop KPIs
  • Initiative and self-motivated with good planning & organizational skills
  • Ability to work simultaneously on different projects
  • Excellent collaboration & communication skills (English)
  • MSc degree (or similar) in Biotechnology, Chemical Engineering, Biochemistry, Biology or a related field with 2+ years relevant industrial experience
  • Industrial expertise with scale-up of organisms larger than small pilot scale (>100L) is highly appreciated to design proper scale-down experiments and mechanisms.
  • Mindset to share your knowledge and experience with other disciplines and learn yourself from these
It would be great if:
  • You have expertise in scale down approaches (matching performance in plates to that in fermentation scale).
  • You are from the Food, Feed, Chemicals or Life Sciences industry and applied production and manufacturing standards
  • You have expertise in Process modeling (SuperPro Designer, ASPEN Plus, etc.).
  • You have experience with multiple microbial hosts and fermentation systems.
  • You have experience with tech transfer of materials and processes to customers and/or contract manufacturing facilities.
  • You have experience in organizing work with lab technicians
  • You have hands on experience with HPLC and similar In-Process-Control Analytics
We offer
We offer an interesting and challenging job in an international atmosphere with the focus on research, teaching, innovation and scientific advice for the benefit of the surrounding community. We place emphasis on a high level of professionalism among our staff, so skills development is an integral part of our organization. We offer a great flexibility in the position. In the area of technical and natural sciences, DTU is one of the leading research and education institutions in Europe.

Salary and terms of employment
The appointment will be based on the collective agreement with the Confederation of Professional Associations. The allowance will be agreed with the relevant union.
Workplace and period of employment:

The place of employment is the DTU main campus in Lyngby.

The position is permanent.

Application procedure and contact
Please submit your online application no later than 21 October 2018. Open the “Apply online” link, fill out the form and attach your motivated application, CV and exam certificates.

If you would like additional information about the position, please contact Dr. Andreas Worberg, heading the piloting and scale-up facility and efforts, +45 9351 8900 or email: andwor@biosustain.dtu.dk

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Biosustain is an international research center of excellence developing next generation cell factories and bioprocesses for sustainable production of high-value chemical compounds as well as protein-based products. The center uses advanced metabolic engineering techniques and computational biology ensuring efficient and cost-effective design and construction processes.
The center’s activities are a balanced mix of basic and translational research, complemented by an emphasis on business development to facilitate commercialization of new cell factories and associated technologies. DTU Biosustain offers state-of-the-art research facilities and assembles world leaders in the field thus offering a unique platform providing excellent talent development and career opportunities.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.