PhD scholarship in Peptide Chemistry

DTU Nanotech
fredag 22 jun 18

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Frist 18. juli 2018
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One PhD position is available in peptide chemistry within biopharmaceutical therapeutics and nanomedicine at The Novo Nordisk Foundation Centre for Intestinal Absorption and Transport of Biopharmaceuticals.

The Novo Nordisk Foundation Centre for Intestinal Absorption and Transport of Biopharmaceuticals invites applications for a fully funded 3-year PhD position in peptide and protein nanocarriers for biopharmaceutical delivery.

Biopharmaceuticals are critically important for current healthcare and hold the potential for new innovative treatments for many diseases and disorders. Unfortunately, many biopharmaceuticals are not absorbed by the intestines and have to be administered by other means (e.g. injection) rather than by tablets or capsules. The Centre for Intestinal Absorption and Transport of Biopharmaceuticals, located at the Technical University of Denmark in the Department of Micro- and Nanotechnology, is focused on developing new methods to significantly increase the absorption of biopharmaceuticals in the intestine so that these drugs may be administered to people as easy to swallow tablets and capsules. The Centre is a multidisciplinary research environment covering the interface between the life and physical sciences with particular emphasis on nanomedicines and the biointerface.

This fully funded 3-year PhD position will focus on synthesis of the peptides which will be used to develop nanocarriers for biopharmaceutical delivery. The project is highly interdisciplinary, and as a part of the synthesis team, you will take part in the preparation of model peptides including relevant conjugation peptides, which will later be formulated and studied by the relevant teams in the Centre.

The Centre for Intestinal Absorption and Transport of Biopharmaceuticals is a global initiative with satellite teams located at Harvard Medical School, Boston Children’s Hospital and Monash University in Melbourne, Australia. PhD students will spend a period of time during the 3 years in one or more of these satellite laboratories.

Responsibilities and tasks
You will work as part of a team of chemists, biologists, microscopists and engineers within the Centre and with external collaborators.

You should have:

  • A strong background in organic chemistry, with a Master’s degree in synthetic organic chemistry or a related field. Experience with peptide synthesis and/or biorthogonal chemistry is an advantage.
  • The ability to work both independently and in a team within interdisciplinary fields. You must have a flexible mindset and be willing to work in an international environment with scientists from various scientific backgrounds.
  • Good time-management skills in order to meet deadlines and achieve the Centre’s milestones.
  • A high degree of personal motivation. Creative and critical thinking skills are vital for the success of the project.
  • Excellent communication skills in English (oral and written). The PhD student will be expected to disseminate their research on a regular basis at center meetings, meetings with external collaborators and conferences.
Qualifications
Candidates should have a master's degree in engineering or a similar degree with an academic level equivalent to the master's degree in engineering.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.

Assessment
The assessment of the applicants will be made by Postdoc Astrid Knuhtsen, Associate Professor Andrew Urquhart and Professor Thomas Lars Andresen.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and an academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed with the relevant union. The period of employment is 3 years.

The PhD candidate should be able to start in Autumn 2018. You will be based at DTU Nanotech, DTU Lyngby Campus.

You can read more about career paths at DTU here.

Further information
Further information may be obtained from Postdoc Astrid Knuhtsen (e-mail: asknu@nanotech.dtu.dk; tel: +45 4525 8134).

You can read more about DTU Nanotech at www.nanotech.dtu.dk

Application
Please submit your online application no later than 18 July 2018.

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill in the online application form, and attach all your materials in English in one PDF file. The file must include:
  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)
Candidates may apply prior to obtaining their master's degree, but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

DTU Nanotech - the Department of Micro- and Nanotechnology - is situated in the northern part of Copenhagen. DTU Nanotech is a centre of excellence in micro- and nanotechnology utilising sciences across the traditional boundaries of technology, thereby enabling innovative solutions for the benefit of society. DTU Nanotech has approximately 270 staff members. With 40 % international employees, the department constitutes an international environment.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.