Postdoc in High Throughput Screening Platforms

DTU Nanotech
mandag 10 sep 18

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Frist 30. september 2018
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We seek an open-minded Postdoc with broad experience in screening using micro systems. High throughput screening is used in many fields including development of new enzymes, antibiotics, production strains etc. Similar procedures can be used for epitope mapping and a range of other biomedical applications. The methodology is always to test millions of different variants and pick the interesting ones. That procedure is costly and slow which limit screens. In this project we intend to investigate alternative miniaturised methods to screen for peptides with certain properties. 

The research is within droplet fluidics. In this case the droplets are immobilised on surfaces and the aim is to refine and test a selection system so that hits can be separated from the many uninteresting droplets. The research is cross disciplinary and involves screening of biological libraries, image analysis, optics and some microfabrication using standardised protocols.  

Responsibilities and tasks 
We seek a candidate that has a broad background in screening biological libraries using microsystems. The research will mainly be to develop HTS application for validating the droplet selection system. We aim to validate the system by screening for peptides that activates GFP or similar model system. Based on the your interests and network other types of screens are expected to be done. It is also possible to broaden your knowledge in fields outside your core competences such as programming and optics. 

You will be responsible for producing droplet arrays using existing protocols and procedures (see Kunding et al. 2018, Lab-on-a Chip journal), explore the limits and possibilities of a droplet selection system using model screening systems and to perform screens on real applications. Depending on the candidate profile, it is also possible to be involved in building that actual system and provide refinements in terms of automation.  

As the research has a very clear industry focus, the postdoc is expected to take part in develop relevant contacts in industries and university colleagues working with these industries. 

You will have the opportunity to guide Master students and to teach at practical courses. 

The project will mostly be done at DTU Nanotech in the groups of Martin Dufva and Niels B. Larsen.  However, within our network there is a large interest in new screening methods within food production, epitope mapping enzyme optimizations and cell biology. We encourage the postdoc to reach out to these communities. 

Qualifications
Candidates should have a PhD degree or equivalent.

As the field is cross disciplinary we may accept candidates from many fields but preferably the candidate has a PhD in the field on bioengineering where the PhD project included usage or development of some micro-systems. Alternatively, the candidate may have a degree in Physics but has worked hands on with biological screening system. A deep understanding of the HTS application is needed which includes assay development, library preparation, and identification and characterisation of the selected biological compound. Image processing is desirable as is programming. 

It is important that you want to learn new technologies and want challenges to work with machine prototypes. 

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The position is a 2-year postdoc. 

You can read more about career paths at DTU here.    

Further information 
Further information may be obtained from Martin Dufva, tel.: +45 5133 3753.

You can read more about the Department of Micro and Nanotechnology at www.nanotech.dtu.dk.  

Application procedure 
Please submit your online application no later than 30 September 2018 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include: 

  • Application (cover letter)
  • CV
  • Diploma (MSc/PhD)
  • List of publications
Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Nanotech - the Department of Micro- and Nanotechnology - is situated in the northern part of Copenhagen. DTU Nanotech is a centre of excellence in micro- and nanotechnology utilising sciences across the traditional boundaries of technology, thereby enabling innovative solutions for the benefit of society. DTU Nanotech has approx. 220 staff members. With 40 % international employees, the department constitutes an international environment.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.