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Frist 8. december 2019
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The
Ubiquitin Signalling and Inflammation
lab is seeking a talented, curious, and highly motivated Postdoc.
The
successful candidate will work on a research project aiming to understand how
the ubiquitin system controls inflammatory signalling and cellular metabolism and
how dysregulation of these pathways may contribute to development of immune
diseases and cancer. The project will involve experimental laboratory work
using molecular cell biology, cell culture systems, and biochemical approaches
to understand how ubiquitin controls cell signalling and cell fate decisions at
the interface of inflammation, cellular metabolism, and cell death. The project
will also include cutting-edge mass spectrometry-based proteomics analyses
performed in collaboration with the DTU Proteomics Core.
The
postdoc will work in the newly
established Ubiquitin Signalling and
Inflammation lab headed by Associate Professor Rune Busk Damgaard. The lab
is part of the Section for Protein Science and Biotherapeutics, headed by
Professor Ulrich auf dem Keller, in the Department of Biotechnology and
Biomedicine, Technical University of Denmark (DTU Bioengineering). The research
group is partially funded by a Hallas-Møller Emerging Investigator grant from
the Novo Nordisk Foundation.
Starting date: March 1st
2020 or as soon as possible thereafter (starting date is flexible and can be
negotiated).
Ubiquitin Signalling
and Inflammation Lab
The
group’s research is focused on understanding how dysregulated immune signalling
leads to inflammatory disease and cancer. The ubiquitin system is critical for
controlling innate immune signalling and transcription factor activation. This
inflammatory response normally protects against infections and tissue damage,
but it can also contribute to development inflammatory disease and cancer when
it is inappropriately activated or dysregulated. We investigate how the
ubiquitin system regulate signalling pathways at the interface of inflammation,
cellular metabolism, and cell death, and how such signalling can contribute to
disease development. Our long-term goal is to identify molecular processes that
can be targeted pharmacologically to treat cancer and other diseases caused by
chronic or dysregulated inflammation.
Read
more about the lab and our research here: https://www.bioengineering.dtu.dk/english/researchny/research-sections/section-for-protein-science-and-biotherapeutics/ubiquitin-signalling-and-inflammation
The
Ubiquitin Signalling and Inflammation
lab is part of the Department of Biotechnology and Biomedicine, Technical
University of Denmark. The department is highly interdisciplinary and a leading
department within life sciences in Denmark, covering both fundamental,
technological, and applied aspects of biological and biomedical research. The successful
candidate will join a young and dynamic newly started lab with excellent
funding and support. The Ubiquitin
Signalling and Inflammation lab has an ambitious, open, encouraging, and
informal working atmosphere and the candidate will benefit from a thriving
international and collaborative community. The lab is located in
state-of-the-art facilities within the Section of Protein Science and
Biotherapeutics, which offers an outstanding research environment and access to
cutting-edge technologies and equipment.
Responsibilities and
tasks
The
project is funded by the Novo Nordisk Foundation and will be focused on understanding
how ubiquitin controls cell signalling and cell fate decisions at the interface
of inflammation, cellular metabolism, and cell death. The role of the candidate will primarily be to perform experiments
in the laboratory, analyse and interpret data, scientific publication, and as
well as attend scientific seminars and conferences.
As a senior member of the lab, the candidate
is expected to assist with supervision and training of junior staff and
students as well as take part in management of the laboratory.
Qualifications
The candidate should hold a PhD in a life
sciences subject (e.g. cell biology, molecular biology, immunology,
biochemistry, or a related subject), have excellent communication skills in
English, and have a documented track record of academic productivity and a
publication record with at least one first-author publication in an
internationally recognised peer-reviewed journal.
The successful candidate should be trained
and have extensive experience in molecular cell biology (including PCR,
molecular cloning, immunoprecipitation, western blotting, etc.), mammalian cell
culture, and analysis of cell signalling and signalling responses. The candidate is expected to have a strong interest in
fundamental scientific discoveries and their translational potential. The Ubiquitin Signalling and Inflammation
lab highly values collaboration,
and it is expected that the candidate can demonstrate a track record and desire
of collaboration with their peers.
Previous
experience with any of the following is highly desirable (but not mandatory):
- Ubiquitin signalling and biology
- Regulation and signalling in cellular
metabolism
- Genome editing (CRISPR/Cas)
- Recombinant protein expression and purification
- Mass spectrometry-based proteomics
Assessment
The assessment of the applicants will be made
by Associate Professor Rune Busk Damgaard together with relevant project partners.
We offer
DTU is a leading technical university globally recognised for the excellence of
its research, education, innovation, and scientific advice. We offer a
rewarding and challenging job in an international environment. We strive for
academic excellence in an environment characterised by collegial respect and
academic freedom tempered by responsibility.
Salary and terms of
employment
The
appointment will be based on the collective agreement with the Danish
Confederation of Professional Associations. The allowance will be agreed upon
with the relevant union.
This
is a full-time position. The period of employment
is 2 years.
You can read
more about career
paths at DTU here.
The
laboratory is located at DTU Lyngby Campus (Greater Copenhagen, Denmark).
Further information
Informal
enquiries and requests for further information should be directed to Associate
Professor Rune Busk Damgaard: damgaard@mrc-lmb.cam.ac.uk
Application
procedure
Please
submit your online application no later than 8 December 2019.
Applications
must be submitted as a single PDF
file containing all materials to be given consideration. To apply,
please open the link "Apply online", fill out the online application
form, and attach all your materials
in English in one PDF file. The file must include:
- Application (cover letter)
- CV
- List of publications
- PhD diploma (or MSc diploma or similar if
PhD degree has not been conferred)
- Names and contact details for two academic
references
Applications and enclosures received after the deadline will not
be considered.
All interested candidates irrespective of age, gender, race, disability,
religion or ethnic background are encouraged to apply.
Technology for people
DTU
develops technology for people. With our international elite research and study
programmes, we are helping to create a better world and to solve the global
challenges formulated in the UN’s 17 Sustainable Development Goals. Hans
Christian Ørsted founded DTU in 1829 with a clear vision to develop and create
value using science and engineering to benefit society. That vision lives on
today. DTU has 11,500 students and 6,000 employees. We work in an international
atmosphere and have an inclusive, evolving, and informal working environment.
Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in
Roskilde and Ballerup.