Postdoc in Quantitative SERS-based Detection for Therapeutic Drug Monitoring

Tuesday 07 Jul 20

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We are looking for a postdoctoral researcher to be part of a dynamic team, working on the development of personalized therapeutic drug monitoring (TDM) solutions using Surface Enhanced Raman Spectroscopy (SERS) based sensing.

The project is part of the BioInnovation Institute (BII) Faculty program, which is a collaboration between BII and DTU and is aimed to create a unique interdisciplinary environment focused on commercialization that can foster novel ideas and lead to new spin-outs.

Our vision is to develop a portable Raman system, which can be used at patient bed side that enables TDM from a single drop of blood in a matter of minutes, using SERS-based sensing. The aim is to commercialize the developed SERS-based tool for TDM and launch a start-up company. A postdoctoral researcher will have an opportunity to be a part of the start-up team which will be finalized at the end of the three-year project.

The project is placed at BII, which will be the primary work place of the postdoctoral researcher, however he or she will have a strong integration with the IDUN research group, led by Prof. Anja Boisen at DTU Department of Health Technology.

IDUN is a large research group with over 40 members, with focus on development of micro and nanosensor sensors, detection systems and drug delivery approaches. In IDUN we have strong competences in Raman spectroscopy, both theory and instrumentation, and several years of experience in the development of high-performance SERS substrates and assays for detection of target analytes in complex matrices (e.g. biological fluids and food samples).

Research field
The postdoctoral researcher will work in the area of SERS. Raman spectroscopy is a well-known spectroscopy technique for identifying various molecular species. SERS, on the other hand, is a powerful experimental technique that utilizes plasmonic nanostructures to enhance otherwise very weak Raman scattering signals. This tremendous amplification of the Raman scattering signal enables detection of trace amounts of target molecules. 

The postdoctoral researcher will work in a team that employs SERS for detection and quantification of anti-cancer drugs in human blood plasma where sample pre-treatment is key. Specifically, the candidate efforts will be focused on (i) sample purification, (ii) development of effective experimental pathways for extracting target molecules (anti-cancer drugs, e.g. methotrexate, imatinib) from a complex, multicomponent matrix (human blood), (iii) assay development. 

Responsibilities and tasks
You will be a part of interdisciplinary research team, where your main responsibility will be the development and validation of SERS-based assays and quantification of therapeutic drugs in blood sample.

You will work in close collaboration with engineers developing Raman detection systems and optimizing SERS substrate as well with other team members, electrochemists, data scientists, physicists working on various aspects of assay development.

Additionally you will interact with collaborators at the hospital who will provide real patient samples and will be involved in the validation process.

Qualifications
Candidates should have a PhD degree or equivalent in the field of analytical chemistry, chemistry or biotechnology. You should also have:

  • Experience in working with quantitative SERS-based detection and data analysis.
  • Experience in the development of sample pre-treatment (e.g. extraction, up-concentration, purification) methods.
  • Experience with immunoassays and different chromatography-based detection methods e.g. LC-MS is a strong plus.
  • Experience working in multidisciplinary teams, self-motivation, responsible conduct of experimental work and good organizational skills are a must.
  • Previous experience in industry in research and development is an additional plus.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 2 years. 

You can read more about career paths at DTU here.  

Further information
Further information may be obtained from Head of Section Professor Anja Boisen, aboi@dtu.dk, tel.: +45 4525 5727, Senior Researcher Kinga Zor, kinzo@dtu.dk, tel.: +45 4525 5751 or Associate Professor Tomas Rindzevicius, trin@dtu.dk, tel: +45 4525 5733. 

Y
ou can read more about DTU Health Tech at www.healthtech.dtu.dk/english

Application procedure
Please submit your online application no later than 15 August 2020 (local time)Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Application (cover letter)
  • CV
  • Diploma (MSc/PhD)
  • List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 175 persons, 130 PhD students and a technical/administrative support staff of about 80 persons.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 11,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.