PhD scholarship in Biomedical Engineering of Biomarkers for Image-Guided Surgery

Friday 30 Aug 19

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A PhD studentship in biomedical engineering of Biomarkers for Image-Guided Surgery is available in the Colloids & Biological interface group (CBIO) at DTU Health Technology.

The section for Biotherapeutic Engineering and Drug Targeting invites applications for a fully funded 3-year PhD positions in biomedical engineering.

Diagnostic imaging technologies such as PET/SPECT/CT and MRI have undergone tremendous development in terms of sensitivity and accuracy, and solid malignancies are identified at increasingly smaller sizes and at earlier stages. However, bridging diagnostic imaging into these surgical procedures has identified unmet needs for biomaterial marker technologies. The current project entails design and testing of biomaterials with multimodal imaging properties enabling the precision of diagnostic imaging in surgical procedures. In particular, near infrared fluorescence, ultrasonography and computed tomography (CT) imaging are considered important aspects of the marker solution.   

The CBIO group is a multidisciplinary research environment covering the interface between the life sciences and physical sciences with particular emphasis on biomaterials and biological interfaces. The CBIO group has a strong focus on translational research bringing projects from the early stage of material synthesis to formulation and further into preclinical testing. To this end, the current project has received great interest from local industry and hospitals.  

The fully funded 3-year PhD student will pursue the following interdisciplinary projects:
 

  • Develop biocompatible near infrared (NIR) fluorescent markers with radiographic contrast for image guided surgical procedures.
  • Evaluate NIR-I and next-generation NIR-II fluorophores that enable deep tissue imaging, and assist in construction of camera solution for surgical testing.
  • Investigate biomaterial tissue interaction with the purpose of controlling cohesive and adhesive properties of the markers.
The CBIO group has a strong collaboration with the preclinical molecular imaging group (CMI), Dept. of Biomedical Sciences and the department of diagnostic imaging Dept. of Small Animal Clinical Sciences, Copenhagen University.

Responsibilities and tasks
The candidates will work as part of a team of scientists within the CBIO group and external collaborators. Willingness to work in an international environment is essential. The successful applicants must demonstrate the following: 
  • A strong background in the physical sciences, preferably with a Master degree in chemistry/physical chemistry/biophysics, analytical chemistry or related topics (e.g. pharmacy, chemical engineering, material science, bionanotechnology etc.). Experience of relevant life sciences (e.g. cell biology, physiology etc.) is a bonus, but not essential.
  • Experience with fluorescence spectroscopy will be highly desirable and knowledge on image analysis is a strong advantage.
  • Experience with biophysical characterization of liquid, gel and solid materials, and a basic knowledge of how such materials interact with tissue.
  • An interest in building camera setups for fluorescence guided surgery.
  • The ability to work both independently and in a team within interdisciplinary fields.
  • A high degree of personal motivation.
  • Creative and critical thinking skills.
  • Excellent communication skills in English (oral and written).
The candidate will have the following responsibilities/tasks: 
  • Learn to and conduct research at a high international level independently and within a team.
  • Conduct themselves in a professional manner.
  • Follow research plans to achieve major and minor goals linked to the project aims.
  • Disseminate their research and help support teaching activities associated with the CBIO group.
The PhD candidate should be able to start Q4 of 2019; however, the state date can be flexible for the right candidate.

Qualifications
Candidates should have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide.  

Assessment
The assessment of the applicants will be made by Senior Scientist Anders E. Hansen and Assoc. Prof. Jonas R. Henriksen.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed with the relevant union. The period of employment is 3 years.

The student will be based at DTU Health Tech, DTU Lyngby Campus. 

You can read more about
career paths at DTU here.  

Further information
Further information may be obtained from Assoc. Prof. Jonas R. Henriksen, email: jhen@dtu.dk; tel: +45 4058 2866.

You can read more about DTU Health Tech on
www.healthtech.dtu.dk/english

Application
Please submit your online application no later than 1 October 2019 (23:59 local time)Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill in the online application form, and attach all your materials in English in one PDF file. The file must include: 
  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)
Candidates may apply prior to obtaining their master's degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent university collaborating globally with business, industry, government and public agencies.