Postdoc in Peptide and Oligonucleotide Synthetic Biology

Wednesday 21 Oct 20

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Apply no later than 1 December 2020
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The primary objective of the project is to evaluate the therapeutic potential of synthetic peptide oligonucleotide conjugates as components of CRISPR CAS9 gene editing system. To ensure effective transport across the blood-brain barrier, RNAs will be conjugated to cell-penetrating peptides. Associate Professor Kira Astakhova at DTU Chemistry will be the main supervisor on the project.

Responsibilities and tasks

  • Develop therapeutic RNA reagents and conjugates with cell-penetrating peptides (CCPs).
  •  Screen and evaluate RNA-CPP conjugates for their ability to induce CRISPR CAS9.
  • Optimize promising RNA sequences by introducing synthetic nucleotides to enhance duplex stability (e.g. LNA) and metabolic resistance (e.g. 2’-OMe)
  • Drafting manuscripts and publish results. 

Qualifications
Candidate should have a PhD degree or equivalent and over 2Y experience in the field of peptide and oligonucleotide synthetic biology.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

This is a 6 month employment with start on January 1st 2021.

You can read more about career paths at DTU here.

Further information
Further information may be obtained from Kira Astakhova, tel.: +45 9351 3552.

You can read more about DTU Chemistry at www.kemi.dtu.dk

Application procedure

Please submit your online application no later than 1 December 2020 (Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Application (cover letter)
  • CV
  • Diploma (MSc/PhD)
  • List of publications
  • 2 letters of recommendation

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,000 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.