Health Technology

Scientists map central part of the immune system

A new paper in Science Advances details how scientists have succeeded in mapping a central part of the immune system – the HLA class II molecules – while accurately predicting how they display fragments of pathogens on the surface of cells.

Illustration of the combined specificity tree for HLA-DR, HLA-DP, and HLA-DQ. Orange molecules have peptide coverage corresponding to at least 50 high-confidence ligands, and blue molecules have a pseudo-sequence distance of at most 0.05 to an orange molecule. Logos in red frames correspond to noncovered molecules. Credit: Jonas Birkelund Nilsson.
Combined specificity tree for HLA-DR, HLA-DP, and HLA-DQ. Orange molecules have peptide coverage corresponding to at least 50 high-confidence ligands, and blue molecules have a pseudo-sequence distance of at most 0.05 to an orange molecule. Logos in red frames correspond to noncovered molecules. Credit: Jonas Birkelund Nilsson.