Establishment of systems metabolic engineering strategies to develop microbial strains

Thursday 05 Nov 15


Sang Yup Lee
Scientific Director
DTU Biosustain

Read the interesting article published in Nature Biotechnology 33, 2015, by Sang Yup Lee and Hyun Uk Kim

Official KAIST press release

Industrial strain development requires system-wide engineeringand optimization of cellular metabolism while considering industrially relevant fermentation and recovery processes. It can be conceptualized as several strategies, which may be implemented in an iterative fashion and in different orders. The key challenges have been the time-, cost- and labor-intensive processes of strain development owing to the difficulties in understanding complex interactions among the metabolic, gene regulatory and signaling networks at the cell level, which are collectively represented as overall system performance under industrial fermentation conditions.

Read the article here