Tilmann Weber

Tilmann Weber

Professor

DTU BIOSUSTAIN
Novo Nordisk Foundation Center for Biosustainability

Technical University of Denmark

Kemitorvet

Building 220, room 327D

2800 Kgs. Lyngby

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2019
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antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

Blin, Kai ; Shaw, Simon ; Steinke, Katharina ; Villebro, Rasmus ; Ziemert, Nadine ; Lee, Sang Yup ; Medema, Marnix H ; Weber, Tilmann
in: Nucleic acids research, vol: 87, issue: W2, pages: W81-W87

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1093/nar/gkz310

 

CRISPR/Cas-based genome engineering in natural product discovery

Tong, Yaojun ; Weber, Tilmann ; Lee, Sang Yup
in: Natural Product Reports

Type: Review (Peer reviewed)

Status: Accepted/In press     |    Year: 2019     |    DOI: https://doi.org/10.1039/C8NP00089A

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Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001.

Devi, Sagarika ; Kiesewalter, Heiko T. ; Kovács, Renátó ; Frisvad, Jens Christian ; Weber, Tilmann ; Larsen, Thomas Ostenfeld ; Kovács, Ákos T. ; Ding, Ling
in: Synthetic and Systems Biotechnology, vol: 4, issue: 3, pages: 142-149

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.synbio.2019.08.002

 

Genome-Scale Metabolic Reconstruction of Actinomycetes for Antibiotics Production

Mohite, Omkar Satyavan ; Weber, Tilmann ; Kim, Hyun Uk ; Lee, Sang Yup
in: Biotechnology Journal, vol: 14, issue: 1

Type: Review (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/biot.201800377

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Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters

Blin, Kai ; Kim, Hyun Uk ; Medema, Marnix H. ; Weber, Tilmann
in: Briefings in Bioinformatics

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2019     |    DOI: https://doi.org/10.1093/bib/bbx146

 

Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH

Villebro, Rasmus ; Shaw, Simon ; Blin, Kai ; Weber, Tilmann
in: Journal of Industrial Microbiology and Biotechnology, vol: 46, issue: 3-4, pages: 469-475

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1007/s10295-018-02131-9

 

Synthetic biology and metabolic engineering of actinomycetes for natural product discovery

Palazzotto, Emilia ; Tong, Yaojun ; Lee, Sang Yup ; Weber, Tilmann
in: Biotechnology Advances

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.biotechadv.2019.03.005

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The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters

Blin, Kai ; Pascal Andreu, Victòria ; de Los Santos, Emmanuel L C ; Del Carratore, Francesco ; Lee, Sang Yup ; Medema, Marnix H. ; Weber, Tilmann
in: Nucleic acids research, vol: 47, issue: D1, pages: D625–D630

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1093/nar/gky1060

2018
 

CRISPR-Cas9 Toolkit for Actinomycete Genome Editing

Tong, Yaojun ; Robertsen, Helene Lunde ; Blin, Kai ; Weber, Tilmann ; Lee, Sang Yup
part of: Synthetic Metabolic Pathways, pages: 163-184, 2018

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1007/978-1-4939-7295-1_11

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Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions

Robertsen, Helene L. ; Musiol-Kroll, Ewa M. ; Ding, Ling ; Laiple, Kristina J. ; Hofeditz, Torben ; Wohlleben, Wolfgang ; Lee, Sang Yup ; Grond, Stephanie ; Weber, Tilmann
in: Scientific Reports, vol: 8

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1038/s41598-018-21507-6

 

Immense diversity found in secondary metabolite gene clusters in filamentous fungi and bacteria using comparative genomics

Vesth, Tammi ; Frisvad, Jens ; Kovács, Ákos ; Jelsbak, Lars ; Weber, Tilmann ; Baker, Scott E. ; Andersen, Mikael R.
Presented at:
17th European Conference on Computational Biology

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2018

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Lysoquinone-TH1, a New Polyphenolic Tridecaketide Produced by Expressing the Lysolipin Minimal PKS II in Streptomyces albus

Hofeditz, Torben ; Unsin, Claudia Eva-Maria ; Wiese, Jutta ; Imhoff, Johannes F. ; Wohlleben, Wolfgang ; Grond, Stephanie ; Weber, Tilmann
in: Antibiotics, vol: 7, issue: 3, pages: 53

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.3390/antibiotics7030053

 

Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms

Palazzotto, Emilia ; Weber, Tilmann
in: Current opinion in Microbiology, vol: 45, pages: 109-116

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.mib.2018.03.004

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Patscanui: an intuitive web interface for searching patterns in DNA and protein data

Blin, Kai ; Wohlleben, Wolfgang ; Weber, Tilmann
in: Nucleic acids research, vol: 46, issue: W1, pages: W205-W208

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1093/nar/gky321

2017
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antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification

Blin, Kai ; Wolf, Thomas ; Chevrette, Marc G. ; Lu, Xiaowen ; Schwalen, Christopher J. ; Kautsar, Satria A. ; Suarez Duran, Hernando G. ; de Los Santos, Emmanuel L. C. ; Kim, Hyun Uk ; Nave, Mariana ; Dickschat, Jeroen S. ; Mitchell, Douglas A. ; Shelest, Ekaterina ; Breitling, Rainer ; Takano, Eriko ; Lee, Sang Yup ; Weber, Tilmann ; Medema, Marnix H.
in: Nucleic acids research, vol: 45, pages: W36-W41

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1093/nar/gkx319

 

Cyanodermella asteris sp. nov. (Ostropales) from the inflorescence axis of Aster tataricus

Jahn, Linda ; Schafhauser, Thomas ; Pan, Stefan ; Weber, Tilmann ; Wohlleben, Wolfgang ; Fewer, David ; Sivonen, Kaarina ; Flor, Liane ; van Pée, Karl-Heinz ; Caradec, Thibault ; Jacques, Philippe ; Huijbers, Mieke M.E. ; van Berkel, Willem J.H. ; Ludwig-Müller, Jutta
in: Mycotaxon, vol: 132, pages: 107-123

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.5248/132.107

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Designing sgRNAs with CRISPy web

Blin, Kai ; Lee, Sang Yup ; Weber, Tilmann
in: Lab Times, issue: 1, pages: 53

Type: Journal article

Status: Published     |    Year: 2017

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Filling The Gaps In The Kirromycin Biosynthetic Gene Cluster In Streptomyces Collinus Tü 365

Robertsen, Helene Lunde ; Musiol-Kroll, Ewa Maria ; Ding, Ling ; Lee, Sang Yup ; Weber, Tilmann
Presented at:
18th International Symposium on the Biology of Actinomycetes

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2017

 

Linking secondary metabolites to biosynthesis genes in the fungal endophyte Cyanodermella asteris: The anti-cancer bisanthraquinone skyrin

Jahn, Linda ; Schafhauser, Thomas ; Wibberg, Daniel ; Rückert, Christian ; Winkler, Anika ; Kulik, Andreas ; Weber, Tilmann ; Flor, Liane ; van Pée, Karl-Heinz ; Kalinowski, Jörn ; Ludwig-Müllera, Jutta ; Wohlleben, Wolfgang
in: Journal of Biotechnology, vol: 257, pages: 233-239

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/j.jbiotec.2017.06.410

 

Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII

Musiol-Kroll, Ewa Maria ; Zubeil, Florian ; Schafhauser, Thomas ; Härtner, Thomas ; Kulik, Andreas ; McArthur, John ; Koryakina, Irina ; Wohlleben, Wolfgang ; Grond, Stephanie ; Williams, Gavin J. ; Lee, Sang Yup ; Weber, Tilmann
in: A C S Synthetic Biology, vol: 6, issue: 3, pages: 421-427

Type: Letter (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1021/acssynbio.6b00341

 

Recent development of computational resources for new antibiotics discovery

Kim, Hyun Uk ; Blin, Kai ; Lee, Sang Yup ; Weber, Tilmann
in: Current opinion in Microbiology, vol: 39, pages: 113-120

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/j.mib.2017.10.027

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The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery

Alanjary, Mohammad ; Kronmiller, Brent ; Adamek, Martina ; Blin, Kai ; Weber, Tilmann ; Huson, Daniel ; Philmus, Benjamin ; Ziemert, Nadine
in: Nucleic acids research, vol: 45, pages: W42-W48

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1093/nar/gkx360

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The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

Blin, Kai ; Medema, Marnix H. ; Kottmann, Renzo ; Lee, Sang Yup ; Weber, Tilmann
in: Nucleic acids research, vol: 45, issue: D1, pages: D555-D559

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1093/nar/gkw960

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Towards systems metabolic engineering of streptomycetes for secondary metabolites production

Robertsen, Helene Lunde ; Weber, Tilmann ; Kim, Hyun Uk ; Lee, Sang Yup
in: Biotechnology Journal

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1002/biot.201700465

2016
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CRISPR/CAS9 based engineering of actinomycetal genomes

Weber, Tilmann ; Tong, Yaojun ; Lee, Sang Yup
Patent no.: WO2016150855, Date: 2016-09-29

Type: Patent

Status: Published     |    Year: 2016

 

Bioinformatics Tools for the Discovery of New Nonribosomal Peptides

Leclère, Valérie ; Weber, Tilmann ; Jacques, Philippe ; Pupin, Maude
part of: Nonribosomal Peptide and Polyketide Biosynthesis, pages: 209-232, 2016, Springer

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1007/978-1-4939-3375-4_14

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CRISPy-web

Blin, Kai ; Pedersen, Lasse Ebdrup ; Weber, Tilmann ; Lee, Sang Yup
in: Synthetic and Systems Biotechnology, vol: 1, issue: 2, pages: 118-121

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1016/j.synbio.2016.01.003

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Elucidating the molecular physiology of lantibiotic NAI-107 production in Microbispora ATCC-PTA-5024

Gallo, Giuseppe ; Renzone, Giovanni ; Palazzotto, Emilia ; Monciardini, Paolo ; Arena, Simona ; Faddetta, Teresa ; Giardina, Anna ; Alduina, Rosa ; Weber, Tilmann ; Sangiorgi, Fabio ; Russo, Alessandro ; Spinelli, Giovanni ; Sosio, Margherita ; Scaloni, Andrea ; Puglia, Anna Maria
in: B M C Genomics, vol: 17, issue: 42

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1186/s12864-016-2369-z

 

Engineering of actinomycetes using CRISPR/Cas9 technologies

Weber, Tilmann ; Tong, Yaojun ; Blin, Kai ; Lee, Sang Yup
in: Planta Medica, vol: 81, issue: S01
Presented at:
9th Joint Meeting of AFERP, ASP, GA, JSP, PSE & SIF

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1055/s-0036-1596147

 

Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365

Iftime, Dumitrita ; Kulik, Andreas ; Härtner, Thomas ; Rohrer, Sabrina ; Niedermeyer, Timo Horst Johannes ; Stegmann, Evi ; Weber, Tilmann ; Wohlleben, Wolfgang
in: Journal of Industrial Microbiology and Biotechnology, vol: 43, issue: 2, pages: 277-291

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1007/s10295-015-1685-7

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Introduction to the Special Issue “Bioinformatic tools and approaches for Synthetic Biology of natural products”

Weber, Tilmann
in: Synthetic and Systems Biotechnology, vol: 1, issue: 2, pages: 67-68

Type: Editorial (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1016/j.synbio.2016.04.001

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Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites

Kim, Hyun Uk ; Charusanti, Pep ; Lee, Sang Yup ; Weber, Tilmann
in: Natural Product Reports, vol: 33, pages: 933-941

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1039/C6NP00019C

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The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus (“Penicillium islandicum”)

Schafhauser, Thomas ; Kirchner, Norbert ; Kulik, Andreas ; Huijbers, Mieke M.E. ; Flor, Liane ; Caradec, Thibault ; Fewer, David P. ; Gross, Harald ; Jacques, Philippe ; Jahn, Linda ; Jokela, Jouni ; Leclère, Valérie ; Ludwig-Müller, Jutta ; Sivonen, Kaarina ; van Berkel, Willem J.H. ; Weber, Tilmann ; Wohlleben, Wolfgang ; van Pée, Karl-Heinz
in: Environmental Microbiology, vol: 18, issue: 11, pages: 3728–3741

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1111/1462-2920.13294

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The evolution of genome mining in microbes – a review

Ziemert, Nadine ; Alanjary, Mohammad ; Weber, Tilmann
in: Natural Product Reports, vol: 33, pages: 988-1005

Type: Review (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1039/C6NP00025H

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The secondary metabolite bioinformatics portal

Weber, Tilmann ; Kim, Hyun Uk
in: Synthetic and Systems Biotechnology, vol: 1, issue: 2, pages: 69-79

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1016/j.synbio.2015.12.002

2015
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antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

Weber, Tilmann ; Blin, Kai ; Duddela, Srikanth ; Krug, Daniel ; Kim, Hyun Uk ; Bruccoleri, Robert ; Lee, Sang Yup ; Fischbach, Michael A. ; Müller, Rolf ; Wohlleben, Wolfgang
in: Nucleic acids research, vol: 43, issue: W1, pages: W237-W243

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1093/nar/gkv437

 

CRISPR-Cas9 Based Engineering of Actinomycetal Genomes

Tong, Yaojun ; Charusanti, Pep ; Zhang, Lixin ; Weber, Tilmann ; Lee, Sang Yup
in: A C S Synthetic Biology, vol: 4, issue: 9, pages: 1020-1029

Type: Journal article (Peer reviewed)

Status: E-pub ahead of print     |    Year: 2015     |    DOI: https://doi.org/10.1021/acssynbio.5b00038

 

Draft genome sequence of Talaromyces islandicus (“Penicillium islandicum”) WF-38-12, a neglected mold with significant biotechnological potential

Schafhauser, Thomas ; Wibberg, Daniel ; Rückert, Christian ; Winkler, Anika ; Flor, Liane ; van Pée, Karl-Heinz ; Fewer, David P. ; Sivonen, Kaarina ; Jahn, Linda ; Weber, Tilmann
in: Journal of Biotechnology, vol: 211, pages: 101-102

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1016/j.jbiotec.2015.07.004

 

Metabolic engineering of antibiotic factories: New tools for antibiotic production in actinomycetes

Weber, Tilmann ; Charusanti, Pep ; Musiol-Kroll, Ewa Maria ; Jiang, Xinglin ; Tong, Yaojun ; Kim, Hyun Uk ; Lee, Sang Yup
in: Trends in Biotechnology, vol: 33, issue: 1, pages: 15-26

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1016/j.tibtech.2014.10.009

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Minimum Information about a Biosynthetic Gene cluster

Medema, Marnix H. ; Kottmann, Renzo ; Yilmaz, Pelin ; Cummings, Matthew ; Biggins, John B. ; Blin, Kai ; de Bruijn, Irene ; Kim, Hyun Uk ; Nielsen, Jens ; Weber, Tilmann
in: Nature Chemical Biology, vol: 11, issue: 9, pages: 625-631

Type: Comment/debate (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1038/nchembio.1890

 

Streptocollin, a type IV lanthipeptide produced by Streptomyces collinus Tü 365

Iftime, Dumitrita ; Jasyk, Martin ; Kulik, Andreas ; Imhoff, Johannes F. ; Stegmann, Evi ; Wohlleben, Wolfgang ; Süssmuth, Roderich D. ; Weber, Tilmann
in: Chembiochem, vol: 16, issue: 18, pages: 2615-2623

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1002/cbic.201500377

2014
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Biosynthesis of Phenylnannolone A, a Multidrug Resistance Reversal Agent from the Halotolerant Myxobacterium Nannocystis pusilla B150

Bouhired, Sarah M. ; Crüsemann, Max ; Almeida, Celso ; Weber, Tilmann ; Piel, Jörn ; Schäberle, Till F. ; König, Gabriele M.
in: ChemBioChem, vol: 15, issue: 5, pages: 757-765

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: https://doi.org/10.1002/cbic.201300676

 

Complete genome sequence of the actinobacterium Amycolatopsis japonica MG417-CF17T (=DSM 44213T) producing (S,S)-N,N′-ethylenediaminedisuccinic acid

Stegmann, Evi ; Albersmeier, Andreas ; Spohn, Marius ; Gert, Helena ; Weber, Tilmann ; Wohlleben, Wolfgang ; Kalinowski, Jörn ; Rückert, Christian
in: Journal of Biotechnology, vol: 189, pages: 46-47

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: https://doi.org/10.1016/j.jbiotec.2014.08.034

 

Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024, Producing the Lantibiotic NAI-107

Sosio, M. ; Gallo, G. ; Pozzi, R. ; Serina, S. ; Monciardini, P. ; Bera, A. ; Stegmann, E. ; Weber, Tilmann
in: Genome Announcements, vol: 2, issue: 1, pages: e01198-13

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: https://doi.org/10.1128/genomeA.01198-13

 

Genome Mining for antibiotics biosynthesis pathways with antiSMASH 3

Weber, Tilmann ; Kim, Hyun Uk ; Blin, Kai ; Takano, Eriko ; Breitling, Rainer ; Medema, Marnix
part of: Abstract Book - DTU Sustain Conference 2014, 2014, Technical University of Denmark (DTU), Kgs. Lyngby
Presented at:
DTU Sustain Conference 2014

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2014

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Improved lanthipeptide detection and prediction for antiSMASH

Blin, Kai ; Kazempour, Daniyal ; Wohlleben, Wolfgang ; Weber, Tilmann
in: P L o S One, vol: 9, issue: 2

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: https://doi.org/10.1371/journal.pone.0089420

 

In silico tools for the analysis of antibiotic biosynthetic pathways.

Weber, Tilmann
in: International Journal of Medical Microbiology, vol: 304, pages: 230-235

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: https://doi.org/10.1016/j.ijmm.2014.02.001

 

KirCII- promising tool for polyketide diversification

Musiol-Kroll, Ewa Maria ; Härtner, Thomas ; Kulik, Andreas ; Wohlleben, Wolfgang ; Weber, Tilmann ; Lee, Sang Yup
part of: Abstract Book - DTU Sustain Conference 2014, 2014, Technical University of Denmark (DTU), Kgs. Lyngby
Presented at:
DTU Sustain Conference 2014

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2014

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Novel Amycolatopsis balhimycina biochemical abilities unveiled by proteomics

Alduina, R. ; Gallo, G. ; Renzone, G. ; Weber, Tilmann ; Scaloni, A. ; Puglia, A. M.
in: F E M S Microbiology Letters, vol: 351, pages: 209-215

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: https://doi.org/10.1111/1574-6968.12324

 

Reprogramming Acyl Carrier Protein Interactions of an Acyl-CoA Promiscuous trans-Acyltransferase

Ye, Zhixia ; Musiol-Kroll, Ewa Maria ; Weber, Tilmann ; Williams, Gavin J.
in: Chemistry & Biology, vol: 21, pages: 636-646

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2014     |    DOI: https://doi.org/10.1016/j.chembiol.2014.02.019

2013
 

antiSMASH 2.0 – a versatile platform for genome mining of secondary metabolite producers

Blin, Kai ; Medema, Marnix H. ; Kazempour, Daniyal ; Fischbach, Michael ; Breitling, Rainer ; Takano, Eriko ; Weber, Tilmann
in: Nucleic acids research, vol: 41, issue: W1, pages: W204-W212

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1093/nar/gkt449

 

Complete genome sequence of the kirromycin producer Streptomyces collinus Tü 365 consisting of a linear chromosome and two linear plasmids

Rückert, C. ; Szczepanowski, R. ; Albersmeier, A. ; Goesmann, A. ; Iftime, D. ; Musiol-Kroll, Ewa Maria ; Blin, K. ; Wohlleben, W. ; Pühler, A. ; Kalinowski, J. ; Weber, Tilmann
in: Journal of biotechnology, vol: 168, pages: 739-740

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1016/j.jbiotec.2013.10.004

 

Detection and quantification of a mycorrhization helper bacterium and a mycorrhizal fungus in plant-soil microcosms at different levels of complexity

Kurth, Florence ; Zeitler, Katharina ; Feldhahn, Lasse ; Neu, Thomas R. ; Weber, Tilmann ; Kristufek, Václav ; Wubet, Tesfaye ; Herrmann, Sylvie ; Buscot, Francois ; Tarkka, Mika T.
in: B M C Microbiology, vol: 13, pages: 205

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1186/1471-2180-13-205

 

Poly Specific trans-Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases

Koryakina, I. ; McArthur, J. ; Randall, S. ; Draelos, M. M. ; Musiol, E. M. ; Muddiman, D. C. ; Weber, Tilmann ; Williams, G. J.
in: A C S Chemical Biology, vol: 8, pages: 200-208

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1021/cb3003489

 

The AT2 domain of KirCI loads malonyl extender units to the ACPs of the kirromycin PKS

Musiol, Ewa-Maria ; Greule, Anja ; Härtner, Thomas ; Kulik, Andreas ; Wohlleben, Wolfgang ; Weber, Tilmann
in: ChemBioChem, vol: 14, pages: 1343-1352

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2013     |    DOI: https://doi.org/10.1002/cbic.201300211

2012
 

CLUSEAN, Overview

Nelson, K.E. (Editor) ; Weber, Tilmann ; Blin, Kai
part of: Encyclopedia of Metagenomics , 2012, Springer Verlag

Type: Encyclopedia chapter (Peer reviewed)

Status: Published     |    Year: 2012

 

Genombasierte Ansätze zur Analyse der Kirromycin-Biosynthese und weiterer Antibiotika-Biosynthesewege

Wohlleben, Prof. Dr. Wolfgang ; Weber, Tilmann

Type: Report (Peer reviewed)

Status: Published     |    Year: 2012

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Genome-scale metabolic representation of Amycolatopsis balhimycina

Vongsangnak, Wanwipa ; Figueiredo, L. F. ; Förster, Jochen ; Weber, Tilmann ; Thykær, Jette ; Stegmann, E. ; Wohlleben, W. ; Nielsen, Jens
in: Biotechnology and Bioengineering (Print), vol: 109, issue: 7, pages: 1798-1807

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2012     |    DOI: https://doi.org/10.1002/bit.24436

 

Synthetic biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production

Wohlleben, W. ; Mast, Y. ; Muth, G. ; Röttgen, M. ; Stegmann, E. ; Weber, Tilmann
in: F E B S Letters, vol: 586, pages: 2171-2176

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2012     |    DOI: https://doi.org/10.1016/j.febslet.2012.04.025

2011
 

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

Medema, M. H. ; Blin, K. ; Cimermancic, P. ; de Jager, V. ; Zakrzewski, P. ; Fischbach, M. A. ; Weber, Tilmann ; Takano, E. ; Breitling, R.
in: Nucleic acids research, vol: 39, pages: W339-W346

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: https://doi.org/10.1093/nar/gkr466

 

Characterization of the "pristinamycin supercluster" of Streptomyces pristinaespiralis

Mast, Yvonne ; Weber, Tilmann ; Golz, Melanie ; Ort-Winklbauer, Regina ; Gondran, Anne ; Wohlleben, Wolfgang ; Schinko, Eva
in: Microbial Biotechnology, vol: 4, issue: 2, pages: 192-206

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: https://doi.org/10.1111/j.1751-7915.2010.00213.x

 

NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity

Röttig, Marc ; Medema, Marnix H. ; Blin, Kai ; Weber, Tilmann ; Rausch, Christian ; Kohlbacher, Oliver
in: Nucleic acids research, vol: 39, pages: W362-367

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: https://doi.org/10.1093/nar/gkr323

 

Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKS

Musiol, Ewa M. ; Härtner, Thomas ; Kulik, Andreas ; Moldenhauer, Jana ; Piel, Jörn ; Wohlleben, Wolfgang ; Weber, Tilmann
in: Chemistry & Biology, vol: 18, pages: 438-444

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: https://doi.org/10.1016/j.chembiol.2011.02.007

 

The phosphopantetheinyl transferase KirP activates the ACP and PCP domains of the kirromycin NRPS/PKS of Streptomyces collinus Tu 365

Pavlidou, M. ; Pross, E. K. ; Musiol, E. M. ; Kulik, A. ; Wohlleben, W. ; Weber, Tilmann
in: F E M S Microbiology Letters, vol: 319, pages: 26-33

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2011     |    DOI: https://doi.org/10.1111/j.1574-6968.2011.02263.x

 

Verfahren zur fermentativen Produktion von D-Phenylglycin

Tübingen, Universität (Inventor) ; Mast, Yvonne (Inventor) ; Schinko, Eva (Inventor) ; Wohlleben, Wolfgang (Inventor) ; Weber, Tilmann ; Ort-Winklbaur, Regina (Inventor)
Date:

Type: Patent

Status: Published     |    Year: 2011

2010
 

Antibiotics, Biosynthesis, Generation of Novel Compounds

Weber, Tilmann
part of: Wiley Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology, 2010, John Wiley and Sons Inc.

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2010     |    DOI: https://doi.org/10.1002/9780470054581.eib040

 

Differential proteomic analysis reveals novel links between primary metabolism and antibiotic production in Amycolatopsis balhimycina

Gallo, G. ; Renzone, G. ; Alduina, R. ; Stegmann, E. ; Weber, Tilmann ; Eliasson Lantz, Anna ; Thykær, Jette ; Sangiorgi, F. ; Scaloni, A. ; Puglia, A.M.
in: Proteomics, vol: 10, issue: 7, pages: 1336-1358

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2010     |    DOI: https://doi.org/10.1002/pmic.200900175

 

Genome mining in Amycolatopsis balhimycina for ferredoxins capable of supporting cytochrome P450 enzymes involved in glycopeptide antibiotic biosynthesis

Geib, Nina ; Weber, Tilmann ; Wörtz, Tanja ; Zerbe, Katja ; Wohlleben, W. ; Robinson, John A.
in: F E M S Microbiology Letters, vol: 306, pages: 45-53

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2010     |    DOI: https://doi.org/10.1111/j.1574-6968.2010.01933.x

 

Increased glycopeptide production after overexpression of shikimate pathway genes being part of the balhimycin biosynthetic gene cluster

Thykær, Jette ; Nielsen, Jens ; Wohlleben, W. ; Weber, Tilmann ; Gutknecht, M. ; Eliasson Lantz, Anna ; Stegmann, E.
in: Metabolic Engineering, vol: 12, issue: 5, pages: 455-461

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2010     |    DOI: https://doi.org/10.1016/j.ymben.2010.05.001

 

Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042

Lopez, P. ; Hornung, A. ; Welzel, K. ; Unsin, C. ; Wohlleben, W. ; Weber, Tilmann ; Pelzer, S.
in: Gene, vol: 461, pages: 5-14

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2010     |    DOI: https://doi.org/10.1016/j.gene.2010.03.016

 

Making E. coli an Erythromycin Production Plant

Weber, Tilmann
in: Chemistry & Biology, vol: 17, issue: 11, pages: 1168-1169

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2010     |    DOI: https://doi.org/10.1016/j.chembiol.2010.11.002

 

Wirkstoff-Forschung aktuell: Funktionelle Genomforschung zur Suche und Optimierung neuer Antibiotika

Weber, Tilmann ; Wohlleben, W.
in: GenomXpress Scholae, vol: 1, pages: 35-38

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2010

2009
 

CLUSEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters

Weber, Tilmann ; Rausch, C. ; Lopez, P. ; Hoof, I. ; Gaykova, V. ; Huson, D. H. ; Wohlleben, W.
in: Journal of biotechnology, vol: 140, pages: 13-17

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2009

 

Functional Genomics zur Suche und Optimierung neuer Wirkstoffe

Weber, Tilmann ; Wohlleben, W.
in: Genomxpress, vol: 9, pages: 11-13

Type: Journal article

Status: Published     |    Year: 2009

 

The kirromycin gene cluster of Streptomyces collinus Tü 365 codes for an aspartate-a-decarboxylase, KirD, which is involved in the biosynthesis of the precursor b-alanine

Laiple, K. J. ; Härtner, T. ; Fiedler, H. P. ; Wohlleben, W. ; Weber, Tilmann
in: The Journal of Antibiotics, vol: 62, pages: 465-468

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2009     |    DOI: https://doi.org/10.1038/ja.2009.67

2008
 

Module extension of a non-ribosomal peptide synthetase of the glycopeptide antibiotic balhimycin produced by Amycolatopsis balhimycina

Butz, Diane ; Schmiederer, Timo ; Hadatsch, Bianka ; Wohlleben, Wolfgang ; Weber, Tilmann ; Süßmuth, Roderich D.
in: ChemBioChem, vol: 9, pages: 1195-1200

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2008     |    DOI: https://doi.org/10.1002/cbic.200800068

 

Molecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of the pyridone moiety

Weber, Tilmann ; Laiple, Kristina Juliane ; Pross, Eva Karoline ; Textor, Adriana ; Grond, Stephanie ; Welzel, Katrin ; Pelzer, Stefan ; Vente, Andreas ; Wohlleben, Wolfgang
in: Chemistry & Biology, vol: 15, pages: 175-188

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2008     |    DOI: https://doi.org/10.1016/j.chembiol.2007.12.009

2005
 

Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis

Donadio, Stefano ; Sosio, Magherita ; Stegmann, Evi ; Weber, Tilmann ; Wohlleben, Wolfgang
in: Molecular Genetics and Genomics, vol: 274, pages: 40-50

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2005     |    DOI: https://doi.org/0.1007/s00438-005-1156-3

 

Nukleinsäuren des Kirromycin-Biosynthese-Genclusters

Weber, Tilmann ; Laiple, K. (Inventor) ; Wohlleben, W. (Inventor) ; Welzel, K. (Inventor) ; Vente, A. (Inventor) ; Pelzer, S. (Inventor)
Date:

Type: Patent

Status: Published     |    Year: 2005

 

Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs)

Rausch, C. ; Weber, Tilmann ; Kohlbacher, O. ; Wohlleben, W. ; Huson, D. H.
in: Nucleic acids research, vol: 33, pages: 5799-5808

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2005     |    DOI: https://doi.org/10.1093/nar/gki885

2004
 

Identifizierung und funktionelle Analyse des Kirromycin-Biosynthese-Genclusters aus Streptomyces collinus Tü 365

Wohlleben, Prof. Dr. W. ; Weber, Tilmann

Type: Doctoral thesis

Status: Published     |    Year: 2004

2003
 

Exploiting the genetic potential of polyketide producing streptomycetes

Weber, Tilmann ; Welzel, K. ; Pelzer, S. ; Vente, A. ; Wohlleben, W.
in: Journal of Biotechnology, vol: 106, pages: 221-232

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2003     |    DOI: https://doi.org/10.1016/j.jbiotec.2003.08.004

2001
 

Evidence that an additional mutation is required to tolerate insertional inactivation of the Streptomyces lividans recA gene

Vierling, Silke ; Weber, Tilmann ; Wohlleben, Wolfgang ; Muth, Günther
in: Journal of Bacteriology, vol: 183, pages: 4374-4381

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2001     |    DOI: https://doi.org/10.1128/JB.183.14.4374-4381.2001

2000
 

Transcriptional and mutational analyses of the Streptomyces lividans recX gene and its interference with RecA activity

Vierling, Silke ; Weber, Tilmann ; Wohlleben, W. ; Muth, G.
in: Journal of Bacteriology, vol: 182, pages: 4005-4011

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2000     |    DOI: https://doi.org/10.1128/JB.182.14.4005-4011.2000