Thomas Lars Andresen

Thomas Lars Andresen

Head of department, professor

DTU HEALTH TECH
Department of Health Technology

Technical University of Denmark

Ørsteds Plads

Building 345B, room 050

2800 Kgs. Lyngby

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2019
 

A tumorsphere model of glioblastoma multiforme with intratumoral heterogeneity for quantitative analysis of cellular migration and drug response

Gudbergsson, Johann Mar ; Kostrikov, Serhii ; Johnsen, Kasper Bendix ; Fliedner, Frederikke Petrine ; Stolberg, Christian Brøgger ; Humle, Nanna ; Hansen, Anders Elias ; Kristensen, Bjarne Winther ; Christiansen, Gunna ; Kjær, Andreas ; Andresen, Thomas Lars ; Duroux, Meg
in: Experimental Cell Research, vol: 379, issue: 1, pages: 73-82

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.yexcr.2019.03.031

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Cationic liposomes

Andresen, Thomas Lars ; Jensen, Simon Skjøde ; Henriksen, Jonas Rosager ; Parhamifar, Ladan ; Lassen, Rasmus Mikkel Münter
Patent no.: WO2019012107 , Date: 2019-01-17

Type: Patent

Status: Published     |    Year: 2019

 

Development and preclinical evaluation of intrinsically radiolabeled [Pd-103] AuPd nanoparticles in an injectable seed-forming system for nanobrachytherapy

Fach, Matthias ; Fliedner, Frederikke ; Kempen, Paul ; Hansen, Anders ; Koster, Ulli ; Kjær, Andreas ; Andresen, Thomas Lars ; Jensen, Andreas ; Henriksen, Jonas
in: Journal of Labelled Compounds and Radiopharmaceuticals, vol: 62, issue: SI suppl. 1, pages: S364-S365

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2019

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Micromotors for drug delivery in vivo: The road ahead

Srivastava, Sarvesh Kumar ; Clergeaud, Gael ; Andresen, Thomas L. ; Boisen, Anja
in: Advanced Drug Delivery Reviews, vol: 138, pages: 41-55

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.addr.2018.09.005

 

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

Johnsen, Kasper Bendix ; Bak, Martin ; Melander, Fredrik ; Thomsen, Maj Schneider ; Burkhart, Annette ; Kempen, Paul Joseph ; Andresen, Thomas Lars ; Moos, Torben
in: Journal of Controlled Release, vol: 295, pages: 237-249

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.jconrel.2019.01.005

 

PEG-Lipid Post Insertion into Drug Delivery Liposomes Quantified at the Single Liposome Level

Eliasen, Rasmus ; Andresen, Thomas L. ; Larsen, Jannik B.
in: Advanced Materials Interfaces, vol: 6, issue: 9

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/admi.201801807

 

Protein Transduction Domain Mimics Facilitate Rapid Antigen Delivery into Monocytes

Backlund, Coralie M. ; Parhamifar, Ladan ; Minter, Lisa ; Tew, Gregory N. ; Andresen, Thomas L.
in: Molecular Pharmaceutics, vol: 16, issue: 6, pages: 2462-2469

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1021/acs.molpharmaceut.9b00070

 

Targeting the transferrin receptor for brain drug delivery

Johnsen, Kasper Bendix ; Burkhart, Annette ; Thomsen, Louiza Bohn ; Andresen, Thomas Lars ; Moos, Torben
in: Progress in Neurobiology, vol: 181

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.pneurobio.2019.101665

 

The hard protein corona of stealth liposomes is sparse

Kristensen, Kasper ; Engel, Trine B. ; Stensballe, Allan ; Simonsen, Jens Bæk ; Andresen, Thomas L.
in: Journal of Controlled Release, vol: 307, pages: 1-15

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.jconrel.2019.05.042

 

Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro

Olesen, Uffe H. ; Clergeaud, Gael ; Lerche, Catharina M. ; Andresen, Thomas Lars ; Haedersdal, Merete
in: Lasers in Surgery and Medicine, vol: 51, issue: 1, pages: 79-87

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/lsm.23013

 

Two-photon fluorescence imaging: a platform to investigate cell-penetrating peptides and liposome-based nanocarriers for drug delivery across the heterogeneous BBB in vivo

Kucharz, K. ; Kristensen, K. ; Kristensen, M. ; Lund, M. ; Andresen, T. ; Brodin, B. ; Lauritzen, M.
in: Journal of Cerebral Blood Flow and Metabolism, vol: 39, issue: 1_suppl, pages: 60-60

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2019

 

Unique Calibrators Derived from Fluorescence-Activated Nanoparticle Sorting for Flow Cytometric Size Estimation of Artificial Vesicles: Possibilities and Limitations

Simonsen, Jens B. ; Larsen, Jannik B. ; Hempel, Casper ; Eng, Niklas ; Fossum, Anna ; Andresen, Thomas L.
in: Cytometry. Part A, vol: 95, issue: 8, pages: 917-924

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/cyto.a.23797

 

What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer

Johnsen, Kasper Bendix ; Gudbergsson, Johann Mar ; Andresen, Thomas Lars ; Simonsen, Jens Bæk
in: BBA Reviews on Cancer, vol: 1871, issue: 1, pages: 109-116

Type: Review (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.bbcan.2018.11.006

2018
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A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies

Tan, Hsih-Yin ; Trier, Sofie ; Rahbek, Ulrik L ; Dufva, Martin ; Kutter, Jörg Peter ; Andresen, Thomas Lars
in: P L o S One, vol: 13, issue: 5

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1371/journal.pone.0197101

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An in Vivo Mouse Model to Investigate the Effect of Local Anesthetic Nanomedicines on Axonal Conduction and Excitability

Moldovan, Mihai ; Alvarez, Susana ; Rothe, Christian ; Andresen, Thomas L. ; Urquhart, Andrew ; Lange, Kai H. W. ; Krarup, Christian
in: Frontiers in Neuroscience, vol: 12

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.3389/fnins.2018.00494

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Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Johnsen, Kasper Bendix ; Bak, Martin ; Kempen, Paul Joseph ; Melander, Fredrik ; Burkhart, Annette ; Thomsen, Maj Schneider ; Nielsen, Morten Schallburg ; Moos, Torben ; Andresen, Thomas Lars
in: Theranostics, vol: 8, issue: 12, pages: 3416-3436

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.7150/thno.25228

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Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future

Mehrali, Mehdi ; Bagherifard, Sara ; Akbari, Mohsen ; Thakur, Ashish ; Mirani, Bahram ; Mehrali, Mohammad ; Hasany, Masoud ; Orive, Gorka ; Das, Paramita ; Emnéus, Jenny ; Andresen, Thomas Lars ; Dolatshahi-Pirouz, Alireza
in: Advanced Science, vol: 5, issue: 10

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1002/advs.201700931

 

Combinatorial Screening of Nanoclay-Reinforced Hydrogels: A Glimpse of the "Holy Grail" in Orthopedic Stem Cell Therapy?

Hasany, Masoud ; Thakur, Ashish ; Taebnia, Nayere ; Kadumudi, Firoz Babu ; Shahbazi, Mohammad-Ali ; Pierchala, Malgorzata Karolina ; Mohanty, Soumyaranjan ; Orive, Gorka ; Andresen, Thomas Lars ; Foldager, Casper Bindzus ; Yaghmaei, Soheila ; Arpanaei, Ayyoob ; Gaharwar, Akhilesh K. ; Mehrali, Mehdi ; Dolatshahi-Pirouz, Alireza
in: ACS Applied Materials and Interfaces, vol: 10, issue: 41, pages: 34924-34941

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1021/acsami.8b11436

 

Combined colorimetric and gravimetric CMUT sensor for detection of benzyl methyl ketone

Mølgaard, Mathias J.G. ; Laustsen, Milan ; Jakobsen, Mogens H. ; Andresen, Thomas L. ; Thomsen, Erik V.
in: Sensors and Actuators B: Chemical, vol: 275, pages: 483-489

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.snb.2018.07.136

 

Development of dual corticosteroid loaded functionalized liposomes for enhanced drug delivery to the retinal endothelium

Arta, Anthoula ; Melander, Fredrik ; Andresen, Thomas Lars ; Urquhart, Andrew
in: Investigative Ophthalmology & Visual Science, vol: 59, issue: 9
Presented at:
ARVO Annual Meeting 2018

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2018

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Endothelial Protein C–Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells

Arta, Anthoula ; Eriksen, Anne Z. ; Melander, Fredrik ; Kempen, Paul ; Larsen, Michael ; Andresen, Thomas L. ; Urquhart, Andrew J.
in: Investigative Ophthalmology & Visual Science, vol: 59, issue: 5, pages: 2119-2132

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1167/iovs.18-23800

 

Feasibility of a novel liquid fiducial marker for use in image guided radiotherapy of oesophageal cancer

de Blanck, Steen Riisgaard ; Scherman-Rydhög, Jonas ; Siemsen, Mette ; Christensen, Merete ; Baeksgaard, Lene ; Jølck, Rasmus Irming ; Specht, Lena ; Andresen, Thomas Lars ; Persson, Gitte Fredberg
in: British Journal of Radiology, vol: 91, issue: 1092

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1259/bjr.20180236

 

Flexible Bioelectronics: Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future (Adv. Sci. 10/2018)

Mehrali, Mehdi ; Bagherifard, Sara ; Akbari, Mohsen ; Thakur, Ashish ; Mirani, Bahram ; Mehrali, Mohammad ; Hasany, Masoud ; Orive, Gorka ; Das, Paramita ; Emnéus, Jenny ; Andresen, Thomas Lars ; Dolatshahi-Pirouz, Alireza

Type: Sound/Visual production (digital)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1002/advs.201870059

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Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts

Christensen, Esben ; Henriksen, Jonas R. ; Jørgensen, Jesper T. ; Amitay, Yasmine ; Schmeeda, Hilary ; Gabizon, Alberto A. ; Kjær, Andreas ; Andresen, Thomas Lars ; Hansen, Anders Elias
in: International Journal of Nanomedicine, vol: 13, pages: 7647-7656

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.2147/IJN.S182579

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How to Characterize Individual Nano-Size Liposomes with Simple Self-Calibrating Fluorescence Microscopy

Mortensen, Kim I. ; Tassone, Chiara ; Ehrlich, Nicky ; Andresen, Thomas L. ; Flyvbjerg, Henrik
in: Nano letters, vol: 18, issue: 5, pages: 2844-2851

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1021/acs.nanolett.7b05312

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How To Characterize Individual Nano-Size Liposomes With Simple Self-Calibrating Fluorescence Microscopy

Mortensen, Kim I. ; Tassone, Chiara ; Ehrlich, Nicky ; Andresen, Thomas L. ; Flyvbjerg, Henrik
Presented at:
69th Annual Conference of the Nordic Microscopy Society

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2018

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Injectable iodine-125 labeled tissue marker for radioactive localization of non-palpable breast lesions

Schaarup-Jensen, Henrik ; Jensen, Andreas Ingemann ; Hansen, Anders Elias ; El Ali, Henrik H. ; Hammershøj, Peter ; Jølck, Rasmus Irming ; Kjær, Andreas ; Andresen, Thomas Lars ; Clausen, Mads Hartvig
in: Acta Biomaterialia, vol: 65, pages: 197-202

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.actbio.2017.10.029

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Liposome accumulation in irradiated tumors display important tumor and dose dependent differences

Hansen, Anders Elias ; Fliedner, Frederikke Petrine ; Henriksen, Jonas Rosager ; Jørgensen, Jesper Tranekjær ; Clemmensen, Andreas Ettrup ; Børresen, Betina ; Elema, Dennis Ringkjøbing ; Kjær, Andreas ; Andresen, Thomas Lars
in: Nanomedicine: Nanotechnology, Biology and Medicine, vol: 14, pages: 27–34

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.nano.2017.08.013

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Long term safety and visibility of a novel liquid fiducial marker foruse in image guided radiotherapy of non-small cell lung cancer

de Blanck, Steen Riisgaard ; Rydhög, Jonas Scherman ; Larsen, Klaus Richter ; Clementsen, Paul Frost ; Josipovic, Mirjana ; Aznar, Marianne Camille ; Rosenschöld, Per Munck af ; Jølck, Rasmus Irming ; Specht, Lena ; Andresen, Thomas Lars ; Persson, Gitte Fredberg
in: Clinical and Translational Radiation Oncology, vol: 13, pages: 24-28

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.ctro.2018.07.004

 

Methotrexate Prodrugs Sensitive to Reactive Oxygen Species for the Improved Treatment of Rheumatoid Arthritis

Andersen, Nikolaj S. ; Peiro Cadahia, Jorge ; Previtali, Viola ; Bondebjerg, Jon ; Hansen, Christian A. ; Hansen, Anders E. ; Andresen, Thomas Lars ; Clausen, Mads H.
in: European Journal of Medicinal Chemistry, vol: 156, pages: 738-746

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.ejmech.2018.07.045

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Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage

Eriksen, Anne Zebitz ; Eliasen, Rasmus ; Oswald, Julia ; Kempen, Paul J. ; Melander, Fredrik ; Andresen, Thomas Lars ; Young, Michael ; Baranov, Petr ; Urquhart, Andrew J.
in: A C S Nano, vol: 12, issue: 8, pages: 7497-7508

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1021/acsnano.8b00596

 

On the use of liposome controls in studies investigating the clinical potential of extracellular vesicle-based drug delivery systems - A commentary

Johnsen, Kasper Bendix ; Gudbergsson, Johann Mar ; Duroux, Meg ; Moos, Torben ; Andresen, Thomas Lars ; Simonsen, Jens Bæk
in: Journal of Controlled Release, vol: 269, pages: 10-14

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.jconrel.2017.11.002

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Remote loading of liposomes with a 124I-radioiodinated compound and their in vivo evaluation by PET/CT in a murine tumor model

Engudar, Gokce ; Schaarup-Jensen, Henrik ; Fliedner, Frederikke P. ; Hansen, Anders E. ; Kempen, Paul ; Jølck, Rasmus I. ; Kjær, Andreas ; Andresen, Thomas L. ; Clausen, Mads H. ; Jensen, Andreas Tue Ingemann ; Henriksen, Jonas Rosager
in: Theranostics, vol: 8, issue: 21, pages: 5828-5841

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.7150/thno.26706

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Remote-loading of liposomes with manganese-52 and in vivo evaluation of the stabilities of 52Mn-DOTA and 64Cu-DOTA using radiolabelled liposomes and PET imaging

Jensen, Andreas I. ; Severin, Gregory W. ; Hansen, Anders Elias ; Fliedner, Frederikke P. ; Eliasen, Rasmus ; Parhamifar, Ladan ; Kjær, Andreas ; Andresen, Thomas Lars ; Henriksen, Jonas Rosager
in: Journal of Controlled Release, vol: 269, pages: 100-109

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.jconrel.2017.11.006

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Synthesis and Evaluation of Hydrogen Peroxide Sensitive Prodrugs of Methotrexate and Aminopterin for the Treatment of Rheumatoid Arthritis

Peiró Cadahía, Jorge ; Bondebjerg, Jon ; Hansen, Christian A. ; Previtali, Viola ; Hansen, Anders E. ; Andresen, Thomas L. ; Clausen, Mads Hartvig
in: Journal of Medicinal Chemistry, vol: 61, issue: 8, pages: 3503-3515

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1021/acs.jmedchem.7b01775

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Theranostic Imaging May Vaccinate against the Therapeutic Benefit of Long Circulating PEGylated Liposomes and Change Cargo Pharmacokinetics

Børresen, Betina ; Henriksen, Jonas R. ; Clergeaud, Gael ; Jørgensen, Jennifer S. ; Melander, Fredrik ; Elema, Dennis R. ; Szebeni, Janos ; Engelholm, Svend Aage ; Kristensen, Annemarie T. ; Kjær, Andreas ; Andresen, Thomas L. ; Hansen, Anders E.
in: ACS Nano, vol: 12, issue: 11, pages: 11386-11398

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1021/acsnano.8b06266

2017
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An assessment of the importance ofexposure routes to the uptake and internal localisation of fluorescent nanoparticles in zebrafish (Danio rerio), using light sheet microscopy

Skjolding, Lars Michael ; Ašmonaitė, G ; Jølck, Rasmus Irming ; Andresen, Thomas Lars ; Selck, H. ; Baun, Anders ; Sturve, J.
in: Nanotoxicology, vol: 11, issue: 3, pages: 351-359

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1080/17435390.2017.1306128

 

Applying fluorescence correlation spectroscopy to investigate peptide-induced membrane disruption

Kristensen, Kasper ; Henriksen, Jonas Rosager ; Andresen, Thomas Lars
part of: Antimicrobial Peptides, pages: 159-180, 2017, Springer

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1007/978-1-4939-6737-7_11

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Artificial Organelles: Intracellular Sub-compartmentalized Microreactors to Conduct Enzymatic Cascade Reactions

Gallardo, Maria Godoy ; Labay, Cédric Pierre ; Trikalitis, Vasileios ; Kempen, Paul ; Larsen, Jannik ; Andresen, Thomas Lars ; Hosta-Rigau, Leticia
part of: Book of Abstracts, Sustain 2017, 2017, Technical University of Denmark
Presented at:
Sustain 2017

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2017

 

Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

Siupka, Piotr ; Hersom, Maria N. S. ; Lykke-Hartmann, Karin ; Johnsen, Kasper B. ; Thomsen, Louiza B. ; Andresen, Thomas Lars ; Moos, Torben ; Abbott, N. Joan ; Brodin, Birger ; Nielsen, Morten S.
in: Journal of Cerebral Blood Flow and Metabolism, vol: 37, issue: 7, pages: 2598-2613

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1177/0271678X17700665

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Combined Colorimetric and Gravimetric CMUT Sensor for Detection of Phenylacetone

Mølgaard, Mathias Johannes Grøndahl ; Laustsen, Milan ; Thygesen, Ida Lysgaard ; Jakobsen, Mogens Havsteen ; Andresen, Thomas Lars ; Thomsen, Erik Vilain
part of: 2017 IEEE International Ultrasonics Symposium (IUS), 2017, IEEE
Presented at:
2017 IEEE International Ultrasonics Symposium (IUS)

Type: Article in proceedings (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1109/ULTSYM.2017.8091676

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Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

Hammershøj, Peter ; Thyhaug, Erling ; Harris, Pernille ; Ek, Pramod Kumar ; Andresen, Thomas Lars ; Clausen, Mads Hartvig
in: Tetrahedron Letters, vol: 58, issue: 16, pages: 1611-1615

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/j.tetlet.2017.03.028

 

Delivering antigen to monocytes using protein transduction domain mimics

Backlund, Coralie ; Tew, Gregory ; Andresen, Thomas Lars ; Parhamifar, Ladan
part of: Proceedings of the 253rd American Chemical Society National Meeting & Exposition, 2018, American Chemical Society
Presented at:
253rd American Chemical Society National Meeting & Exposition

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2017

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Enhanced efficacy of sublingual immunotherapy by liposome-mediated delivery of allergen

Aliu, Have ; Rask, Carola ; Brimnes, Jens ; Andresen, Thomas Lars
in: International Journal of Nanomedicine, vol: 12, pages: 8377-8388

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.2147/IJN.S137033

 

Liquid fiducial marker applicability in proton therapy of locally advanced lung cancer

Scherman Rydhög, Jonas ; Perrin, Rosalind ; Jølck, Rasmus Irming ; Gagnon-Moisan, Francis ; Larsen, Klaus Richter ; Clementsen, Paul ; Riisgaard de Blanck, Steen ; Fredberg Persson, Gitte ; Weber, Damien Charles ; Lomax, Tony ; Andresen, Thomas Lars ; Munck af Rosenschold, Per
in: Radiotherapy & Oncology, vol: 122, issue: 3, pages: 393-399

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/j.radonc.2016.12.027

 

Modulating antibody affinity towards the transferrin receptor to increase brain uptake of anti-transferrin receptor antibody targeted gold nanoparticles

Johnsen, Kasper Bendix ; Bak, Martin ; Melander, Fredrik ; Burkhart, Annette ; Kempen, Paul ; Andresen, Thomas Lars ; Moos, Torben
in: American Journal of Hematology, vol: 92, issue: 8, pages: E198-E198

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2017

 

Multicompartment Artificial Organelles Conducting Enzymatic Cascade Reactions inside Cells

Gallardo, Maria Godoy ; Labay, Cédric Pierre ; Trikalitis, Vasileios ; Kempen, Paul ; Larsen, Jannik ; Andresen, Thomas Lars ; Hosta-Rigau, Leticia
in: A C S Applied Materials and Interfaces, vol: 9, issue: 19, pages: 15907-15921

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1021/acsami.6b16275

 

Multicompartment microreactors with preserved intracellular activity: A step towards the creation of artificial organelles

Gallardo, Maria Godoy ; Labay, Cédric Pierre ; Trikalitis, Vasileios ; Jansman, Michelle ; Ek, Pramod Kumar ; Kempen, Paul ; Larsen, Jannik ; Andresen, Thomas Lars ; Hosta-Rigau, Leticia
in: American Chemical Society. Abstracts of Papers (at the National Meeting), vol: 254

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2017

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Palpable marker composition

Andresen, Thomas Lars ; Jølck, Rasmus Irming ; Bruun, Linda Maria
Patent no.: WO2017198858 , Date: 2017-11-23

Type: Patent

Status: Published     |    Year: 2017

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PET imaging with copper-64 as a tool for real-time in vivo investigations of the necessity for crosslinking of polymeric micelles in nanomedicine

Jensen, Andreas Tue Ingemann ; Binderup, Tina ; Ek, Pramod Kumar ; Grandjean, Constance E ; Rasmussen, Palle ; Kjær, Andreas ; Andresen, Thomas Lars
in: Journal of Labelled Compounds and Radiopharmaceuticals, vol: 60, issue: 8, pages: 366-374

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1002/jlcr.3510

 

Recent advances in compartmentalized synthetic architectures as drug carriers, cell mimics and artificial organelles

York-Durán, María José ; Gallardo, Maria Godoy ; Labay, Cédric Pierre ; Urquhart, Andrew ; Andresen, Thomas Lars ; Hosta-Rigau, Leticia
in: Colloids and Surfaces B: Biointerfaces, vol: 152, pages: 199-213

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/j.colsurfb.2017.01.014

 

Revisiting the use of sPLA2-sensitive liposomes in cancer therapy

Pourhassan, Houman ; Clergeaud Veiga, Gael ; Hansen, Anders Elias ; Østrem, Ragnhild Garborg ; Fliedner, Frederikke P. ; Melander, Fredrik ; Nielsen, Ole L. ; O'Sullivan, Ciara K. ; Kjær, Andreas ; Andresen, Thomas Lars
in: Journal of Controlled Release, vol: 261, pages: 163-173

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/j.jconrel.2017.06.024

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Secretory phospholipase A2 responsive liposomes exhibit a potent anti-neoplastic effect in vitro, but induce unforeseen severe toxicity in vivo

Østrem, Ragnhild Garborg ; Parhamifar, Ladan ; Pourhassan, Houman ; Clergeaud Veiga, Gael ; Nielsen, Ole L. ; Kjær, Andreas ; Hansen, Anders Elias ; Andresen, Thomas Lars
in: Journal of Controlled Release, vol: 262, pages: 212-221

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/j.jconrel.2017.07.031

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18F-FDG PET/CT-based early treatment response evaluation of nanoparticle-assisted photothermal cancer therapy

Norregaard, Kamilla ; Jørgensen, Jesper T. ; Simón, Marina ; Melander, Fredrik ; Kristensen, Lotte K. ; Bendix, Pól M. ; Andresen, Thomas Lars ; Oddershede, Lene B. ; Kjær, Andreas
in: P L o S One, vol: 12, issue: 5

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1371/journal.pone.0177997

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Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

Johnsen, Kasper B. ; Burkhart, Annette ; Melander, Fredrik ; Kempen, Paul ; Bruun, Jonas ; Siupka, Piotr ; Nielsen, Morten Schallburg ; Andresen, Thomas Lars ; Moos, Torben
in: Scientific Reports, vol: 7, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1038/s41598-017-11220-1

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The diffusion dynamics of PEGylated liposomes in the intact vitreous of the ex vivo porcine eye: A fluorescence correlation spectroscopy and biodistribution study

Eriksen, Anne Zebitz ; Brewer, Jonathan ; Andresen, Thomas Lars ; Urquhart, Andrew
in: International Journal of Pharmaceutics, vol: 522, issue: 1-2, pages: 90-97

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/j.ijpharm.2017.03.003

 

Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain

Burkhart, Annette ; Andresen, Thomas Lars ; Aigner, Achim ; Thomsen, Louiza Bohn ; Moos, Torben
in: Cellular and Molecular Life Sciences, vol: 74, pages: 2467-2485

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1007/s00018-017-2501-5

2016
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Affinity Induced Surface Functionalization of Liposomes Using Cu-Free Click Chemistry

Bak, Martin ; Jølck, Rasmus Irming ; Eliasen, Rasmus ; Andresen, Thomas Lars
in: Bioconjugate Chemistry, vol: 27, issue: 7, pages: 1673-80

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1021/acs.bioconjchem.6b00221

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A microfluidic cell culture device with integrated microelectrodes for barrier studies.

Tan, Hsih-Yin ; Dufva, Martin ; Kutter, Jörg P. ; Andresen, Thomas Lars
Presented at:
Organ-on-a-Chip World Congress & 3D-Culture 2016

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2016

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A microfluidic cell culture device with integrated microelectrodes for barrier studies.

Tan, Hsih-Yin ; Dufva, Martin ; Kutter, Jörg P. ; Andresen, Thomas Lars
Presented at:
Organ-on-a-Chip World Congress & 3D-Culture 2016

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2016

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An ATP Binding Cassette Transporter Mediates the Uptake of α-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates

Hansen, Morten Ejby ; Fredslund, Folmer ; Andersen, Joakim Mark ; Žagar, Andreja Vujičić ; Henriksen, Jonas Rosager ; Andresen, Thomas Lars ; Svensson, Birte ; Slotboom, Dirk Jan ; Abou Hachem, Maher
in: Journal of Biological Chemistry, vol: 291, issue: 38, pages: 20220-20231

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1074/jbc.M116.746529

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Binding of human serum albumin to liposomes studied by fluorescence correlation spectroscopy

Kristensen, Kasper ; Urquhart, Andrew ; Thormann, Esben ; Andresen, Thomas Lars
Presented at:
The 43rd Annual Meeting & Exposition of the Controlled Release Society

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2016

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Contructive delivery of cancer chemotherapeutics using virus inspired liposomes.

Larsen, Jannik Bruun ; Clergeaud Veiga, Gael ; Eliasen, Rasmus ; Melander, Fredrik ; Kirchhausen, Tom ; Andresen, Thomas Lars
Presented at:
14th European Symposium on Controlled Drug Delivery

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2016

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Elucidating the role of free polycations in gene knockdown by siRNA polyplexes

Klauber, Thomas Christopher Bogh ; Søndergaard, Rikke Vicki ; Sawant, Rupa R. ; Torchilin, Vladimir P. ; Andresen, Thomas Lars
in: Acta Biomaterialia, vol: 15, issue: 35, pages: 248-259

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1016/j.actbio.2016.02.021

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Evaluating liposomal nanoparticles for controlled release of chemotherapeutics in vitro and in vivo

Østrem, Ragnhild Garborg ; Nielsen, Ole Lerberg ; Hansen, Anders Elias ; Andresen, Thomas Lars
Presented at:
Clinical Nanomedicine and Targeted Medicine 2016

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2016

 

Gold Nanoparticles with Stably Embedded Cu-64 and Their Use in Nanoparticle Research

Jensen, A.I. ; Frellsen, Anders Floor ; Hansen, A. E. ; Jølck, Rasmus Irming ; Severin, Gregory ; Tietze, Sabrina ; Kempen, Paul ; Rasmussen, P.H. ; Kjaer, A. ; Andresen, Thomas Lars
in: European Journal of Nuclear Medicine and Molecular Imaging, vol: 43, issue: Supplement 1, pages: S536-S537
Presented at:
Annual Congress of the European Association of Nuclear Medicine

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1007/s00259-016-3484-4

 

Injectable silver nanosensors: in vivo dosimetry for external beam radiotherapy using positron emission tomography

Christensen, Anders Nymark ; Rydhög, J. S. ; Søndergaard, Rikke Vicki ; Andresen, Thomas Lars ; Holm, S. ; Munck af Rosenschöld, P. ; Conradsen, Knut ; Jølck, R. I.
in: Nanoscale, vol: 8, issue: 21, pages: 11002-11011

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1039/c6nr00201c

 

In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines

Roursgaard, Martin ; Knudsen, Kristina Bram ; Northeved, Helle ; Persson, Mikael ; Christensen, Tina ; Ek, Pramod Kumar ; Permin, Anders ; Andresen, Thomas Lars ; Gjetting, Torben ; Lykkesfeldt, Jens ; Vesterdal, Lise K ; Loft, Steffen ; Møller, Peter
in: Toxicology in Vitro, vol: 36, pages: 164-171

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1016/j.tiv.2016.08.002

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In vivo Evaluation of PEGylated 64Cu-liposomes with Theranostic and Radiotherapeutic Potential using Micro PET/CT

Petersen, Anncatrine Luisa ; Henriksen, Jonas Rosager ; Binderup, Tina ; Elema, Dennis Ringkjøbing ; Rasmussen, Palle Hedengran ; Hag, Anne Mette ; Kjær, Andreas ; Andresen, Thomas Lars
in: European Journal of Nuclear Medicine and Molecular Imaging, vol: 43, issue: 5, pages: 941-952

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1007/s00259-015-3272-6

 

Liquid fiducial marker performance during radiotherapy of locally advanced non small cell lung cancer

Rydhög, Jonas Scherman ; Mortensen, Steen Riisgaard ; Larsen, Klaus Richter ; Clementsen, Paul ; Jølck, Rasmus Irming ; Josipovic, Mirjana ; Aznar, Marianne Camille ; Specht, Lena ; Andresen, Thomas Lars ; Rosenschöld, Per Munck Af ; Persson, Gitte Fredberg
in: Radiotherapy & Oncology, vol: 121, issue: 1, pages: 64-69

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1016/j.radonc.2016.06.012

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Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease

Matrone, Carmela ; Dzamko, Nicolas ; Madsen, Peder ; Nyegaard, Mette ; Pohlmann, Regina ; Søndergaard, Rikke Vicki ; Lassen, Louise B. ; Andresen, Thomas Lars ; Halliday, Glenda M. ; Jensen, Poul Henning ; Nielsen, Morten S.
in: P L o S One, vol: 11, issue: 8

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1371/journal.pone.0160501

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Matrix metalloprotease-sensitive doxorubicin-loaded liposomes for enhanced anticancer activity.

Clergeaud Veiga, Gael ; Fliedner, Frederikke P. ; Hansen, Anders Elias ; Melander, Fredrik ; Kjær, Andreas ; Andresen, Thomas Lars
Presented at:
The 43rd Annual Meeting & Exposition of the Controlled Release Society

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2016

 

Multiplexed Dosing Assays by Digitally Definable Hydrogel Volumes

Faralli, Adele ; Melander, Fredrik ; Larsen, Esben Kjær Unmack ; Chernyy, Sergey ; Andresen, Thomas Lars ; Larsen, Niels Bent
in: Advanced Healthcare Materials, vol: 5, issue: 2, pages: 244–254

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1002/adhm.201500542

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Nanomechanical IR spectroscopy for fast analysis of liquid-dispersed engineered nanomaterials

Andersen, Alina Joukainen ; Yamada, Shoko ; Ek, Pramod Kumar ; Andresen, Thomas Lars ; Boisen, Anja ; Schmid, Silvan
in: Sensors and Actuators B: Chemical, vol: 233, pages: 667-673

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1016/j.snb.2016.04.002

 

Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide

Ke, Peng ; Sun, Honghao ; Liu, Mingxing ; Su, Zhengding ; Hu, Kanghong ; Zhua, Hongda ; Guo, Huilin ; Sun, Hongmei ; Andresen, Thomas Lars ; Olsen, Lars Folke
in: IET Nanobiotechnology, vol: 10, issue: 1, pages: 8-12

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1049/iet-nbt.2014.0070

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Redox-Sensitive liposomes for glioblastoma treatment.

Lund, Mette Aagaard ; Bak, Martin ; Kamaly, Nazila ; Andresen, Thomas Lars
Presented at:
19th International Symposium on Signal Transduction at the Blood-Brain Barriers

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2016

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Redox-Sensitive liposomes for glioblastoma treatment.

Lund, Mette Aagaard ; Bak, Martin ; Kamaly, Nazila ; Andresen, Thomas Lars
Presented at:
19th International Symposium on Signal Transduction at the Blood-Brain Barriers

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2016

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sPLA2 sensitive fluid phase liposomes induce severe toxicity in murine cancer model

Østrem, Ragnhild Garborg ; Nielsen, Ole L. ; Hansen, Anders E. ; Andresen, Thomas Lars
Presented at:
Clinical Nanomedicine and Targeted Medicine 2016

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2016

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Targeting the DCIR Receptor with a TLR7 Agonist Specifically Activates Monocytes and DCs

Klauber, Thomas Christopher Bogh ; Laursen, Janne Marie ; Maj, R. ; Pedersen, Susanne Brix ; Jensen, Simon Skjøde ; Andresen, Thomas Lars
Presented at:
The 43rd Annual Meeting & Exposition of the Controlled Release Society

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2016

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The impact of transferrin receptor targeting on immunoliposomal cargo delivery across the blood-brain barrier.

Johnsen, Kasper B. ; Andresen, Thomas Lars ; Moos, Torben
part of: Abstracts of papers presented at the 2016 meeting on Blood Brain Barrier, pages: 39-39, 2016
Presented at:
Fifth Cold Spring Harbor conference on Blood Brain Barrier

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2016

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Ultrasound-mediated delivery of novel bio-responsive nanoparticles

Sereti, Viktoria ; Olsman, Marieke ; Andresen, Thomas Lars ; Davies, Catharina de Lange
Presented at:
The 8th National PhD Conference in Medical Imaging

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2016

2015
 

3D Biomaterial Microarrays for Regenerative Medicine

Gaharwar, Akhilesh K. ; Arpanaei, Ayyoob ; Andresen, Thomas Lars ; Dolatshahi-Pirouz, Alireza
in: Advanced Materials, vol: 28, issue: 4, pages: 771-781

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1002/adma.201503918

 

Acylation of salmon calcitonin modulates in vitro intestinal peptide flux through membrane permeability enhancement

Trier, Sofie ; Linderoth, Lars ; Bjerregaard, Simon ; Strauss, Holger M ; Rahbek, Ulrik L. ; Andresen, Thomas Lars
in: European Journal of Pharmaceutics and Biopharmaceutics, vol: 96, pages: 329-337

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1016/j.ejpb.2015.09.001

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Adsorption of Cationic Peptides to Solid Surfaces of Glass and Plastic

Kristensen, Kasper ; Henriksen, Jonas Rosager ; Andresen, Thomas Lars
in: P L o S One, vol: 10, issue: 5

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1371/journal.pone.0122419

 

A hydrogel based nanosensor with an unprecedented broad sensitivity range for pH measurements in cellular compartments

Zhang, M. ; Søndergaard, Rikke Vicki ; Ek, Pramod Kumar ; Henriksen, Jonas Rosager ; Cui, D. ; Hammershøj, Peter ; Clausen, Mads Hartvig ; Andresen, Thomas Lars
in: Analyst, vol: 140, pages: 7246-7253

Type: Journal article (Peer reviewed)

Status: E-pub ahead of print     |    Year: 2015     |    DOI: https://doi.org/10.1039/c5an01014d

 

Facile Large-Scale Synthesis of 5- and 6-Carboxyfluoresceins

Hammershøj, Peter ; Ek, Pramod Kumar ; Harris, Pernille ; Andresen, Thomas Lars ; Clausen, Mads Hartvig
in: European Journal of Organic Chemistry, vol: 2015, issue: 33, pages: 7301-7309

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1002/ejoc.201501013

 

Facing the Design Challenges of Particle-Based Nanosensors for Metabolite Quantification in Living Cells

Søndergaard, Rikke Vicki ; Christensen, Nynne Meyn ; Henriksen, Jonas Rosager ; Ek, Pramod Kumar ; Almdal, Kristoffer ; Andresen, Thomas Lars
in: Chemical Reviews, vol: 115, issue: 16, pages: 8344-8378

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1021/cr400636x

 

Impedimetric Toxicity Assay Evaluating Free and Liposome-loaded Anticancer drugs

Caviglia, Claudia ; Garbarino, Francesca ; Zor, Kinga ; Brogaard, Rikke Yding ; Melander, Fredrik ; Eliasen, Rasmus ; Carminati, M. ; Ferrari, G. ; Raiteri, R. ; Andresen, Thomas Lars ; Heiskanen, Arto ; Emnéus, Jenny
Presented at:
XXIII International Symposium on Bioelectrochemistry and Bioenergetics

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2015

 

Impedimetric toxicity assay in microfluidics using free and liposome-encapsulated anticancer drugs

Caviglia, Claudia ; Zor, Kinga ; Montini, Lucia ; Tilli, Valeria ; Canepa, Silvia ; Melander, Fredrik ; Larsen, Layla Bashir ; Carminati, Marco ; Ferrari, Giorgio ; Raiteri, Roberto ; Heiskanen, Arto ; Andresen, Thomas Lars ; Emnéus, Jenny
in: Analytical chemistry, vol: 87, issue: 4, pages: 2204-2212

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1021/ac503621d

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Injectable Colloidal Gold for Use in Intrafractional 2D Image-Guided Radiation Therapy

Jølck, Rasmus Irming ; Rydhog, Jonas S. ; Christensen, Anders Nymark ; Hansen, Anders Elias ; Bruun, Linda Maria ; Schaarup-Jensen, Henrik ; von Wenck, Asger Stevner ; Borresen, Betina ; Kristensen, Annemarie T. ; Clausen, Mads Hartvig ; Kjær, Andreas ; Conradsen, Knut ; Larsen, Rasmus ; af Rosenschold, Per Munck ; Andresen, Thomas Lars
in: Advanced Healthcare Materials, vol: 4, issue: 6, pages: 856-863

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1002/adhm.201400651

 

Interdependence of initial cell density, drug concentration and exposure time revealed by real-time impedance spectroscopic cytotoxicity assay

Caviglia, Claudia ; Zor, Kinga ; Canepa, Silvia ; Carminati, M. ; Larsen, Layla Bashir ; Raiteri, R. ; Andresen, Thomas Lars ; Heiskanen, Arto ; Emnéus, Jenny
in: Analyst, vol: 140, issue: 10, pages: 3623-3629

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2015     |    DOI: https://doi.org/10.1039/c5an00097a