Sunil Kumar Saini

Sunil Kumar Saini

Assistant Professor

DTU HEALTH TECH
Department of Health Technology

Technical University of Denmark

Kemitorvet

Building 204, room 151

2800 Kgs. Lyngby

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2019
 

Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells

Saini, Sunil Kumar ; Tamhane, Tripti ; Anjanappa, Raghavendra ; Saikia, Ankur ; Ramskov, Sofie ; Donia, Marco ; Svane, Inge Marie ; Jakobsen, Søren Nyboe ; Garcia-Alai, Maria ; Zacharias, Martin ; Meijers, Rob ; Springer, Sebastian ; Hadrup, Sine Reker
in: Science Immunology, vol: 4, issue: 37

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1126/sciimmunol.aau9039

 

HLA-C restricted neoepitopes contribute significantly to the immune recognition of cancer

Ramskov, Sofie ; Hansen, Kring U. ; Saini, Kumar S. ; Sturm, T. ; Borch, Annie ; Bjerregaard, Anne-Mette ; Bentzen, Kai A. ; Marquard, Marion A. ; Donia, M. ; Andersen, R. ; Draghi, A. ; Reading, J. ; Vogler, I. ; Derhovanessian, E. ; Lassen, U. ; Sahin, U. ; Swanton, A. C. ; Quezada, S. ; Svane, I. M. ; Fugmann, T. ; Hadrup, Reker S.
in: European Journal of Immunology, vol: 49, issue: Suppl. 3 SI, pages: 387-387
Presented at:
17th International Congress of Immunology

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2019

2018
  PDF

Human endogenous retroviruses and their implication for immunotherapeutics of cancer

Attermann, A.S. ; Bjerregaard, AM. ; Saini, S.K. ; Grønbæk, K. ; Hadrup, S.R.
in: Annals of Oncology, vol: 29, issue: 11, pages: 2183–2191

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1093/annonc/mdy413

2017
 

Induction of Antigen-Specific T Cells Targeting Endogenous Retroelements During Epigenetic Treatment of Myelodysplastic Syndrome

Ørskov, A. D. ; Saini, Sunil Kumar ; Bjerregaard, Anne-Mette ; Otani, H. ; Holmberg, S. ; Treppendahl, M. B. ; Gang, A. O. ; Dufva, I. H. ; Liang, G. ; Eklund, Aron Charles ; Jones, P. A. ; Gronbaek, K. ; Hadrup, Sine Reker
in: Leukemia Research, vol: 55, pages: S66-S67

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/S0145-2126(17)30220-5

 

Modulation of the Immune System by Epigenetic Therapy: A Rationale for Combined Use of DNA Methyltransferase Inhibitors and Immune Checkpoint Inhibitors

Kirsten, Gronbaek ; Orskov, A. D. ; Ohtani, H. ; Treppendahl, Marianne ; Liu, M. ; Hansen, J. W. ; Saini, Sunil Kumar ; Baylin, S. B. ; O'Connell, Casey ; Liang, G. ; Hadrup, Sine Reker ; Jones, P. A.
in: Annals of Hematology, vol: 96, issue: Suppl. 1, pages: S46-S47

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1007/s00277-017-2921-1

 

Novel tools to assist neoepitope targeting in personalized cancer immunotherapy

Saini, Sunil Kumar ; Rekers, Nicolle ; Hadrup, Sine Reker
in: Annals of Oncology, vol: 28, issue: suppl_12, pages: 3-10

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1093/annonc/mdx544

2016
  PDF

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

McGranahan, Nicholas ; Furness, Andrew J S ; Rosenthal, Rachel ; Andersen, Sofie Ramskov ; Lyngaa, Rikke Birgitte ; Saini, Sunil Kumar ; Jamal-Hanjani, Mariam ; Wilson, Gareth A ; Birkbak, Nicolai J. ; Hiley, Crispin T ; Watkins, Thomas B K ; Shafi, Seema ; Murugaesu, Nirupa ; Mitter, Richard ; Akarca, Ayse U ; Linares, Joseph ; Marafioti, Teresa ; Henry, Jake Y ; Van Allen, Eliezer M ; Miao, Diana ; Schilling, Bastian ; Schadendorf, Dirk ; Garraway, Levi A ; Makarov, Vladimir ; Rizvi, Naiyer A ; Snyder, Alexandra ; Hellmann, Matthew D ; Merghoub, Taha ; Wolchok, Jedd D ; Shukla, Sachet A ; Wu, Catherine J ; Peggs, Karl S ; Chan, Timothy A ; Hadrup, Sine Reker ; Quezada, Sergio A ; Swanton, Charles
in: Science, vol: 351, issue: 6280, pages: 1463-1469

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1126/science.aaf1490

 

Impact Of Mutation-derived Antigens In Immune Recognition Of Hematological Malignancies, Specifically Myeloid Dysplastic Syndromes (MDS)

Saini, Sunil Kumar ; Dorfmüller, S. ; Bjerregaard, Anne-Mette ; Bentzen, Amalie Kai ; Eklund, Aron Charles ; Medyouf, H. ; Hadrup, Sine Reker
in: Haematologica, vol: 101, issue: S1, pages: 66-66
Presented at:
21st Congress of the European Hematology Association

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2016

 

Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes

Bentzen, Amalie Kai ; Marquard, Andrea Marion ; Lyngaa, Rikke Birgitte ; Saini, Sunil Kumar ; Andersen, Sofie Ramskov ; Donia, Marco ; Such, Lina ; Furness, Andrew J. S. ; McGranahan, Nicholas ; Rosenthal, Rachel ; Straten, Per Thor ; Szallasi, Zoltan Imre ; Svane, Inge Marie ; Swanton, Charles ; Quezada, Sergio A. ; Jakobsen, Søren Nyboe ; Eklund, Aron Charles ; Hadrup, Sine Reker
in: Nature Biotechnology, vol: 34, issue: 10, pages: 1037-1045

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1038/nbt.3662

 

Next-generation detection of antigen-responsive T cells using DNA barcode-labeled peptide-major histocompatibility complex I multimers

Bentzen, Amalie Kai ; Marquard, Andrea Marion ; Lyngaa, Rikke Birgitte ; Saini, Sunil Kumar ; Andersen, S. R. ; Donia, M. ; Svane, I. M. ; thor Straten, P. ; Szallasi, Zoltan Imre ; Jakobsen, S. N. ; Eklund, Aron Charles ; Hadrup, Sine Reker
in: European Journal of Immunology, vol: 46, issue: S1, pages: 8-8
Presented at:
ICI 2016 International Congress of Immunology

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: https://doi.org/10.1002/eji.201670200