Pernille Harris

Pernille Harris

Professor

DTU CHEMISTRY
Department of Chemistry

Kemi: Faculty
Physical and Biophysical Chemnistry: Protein and X-ray Crystallography

Technical University of Denmark

Building 206, room 210

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2020
 

Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization

Gentiluomo, Lorenzo ; Svilenov, Hristo L ; Augustijn, Dillen ; El Bialy, Inas ; Greco, Maria Laura ; Vitaliyivna Kulakova, Alina ; Indrakumar, Sowmya ; Mahapatra, Sujata ; Morales, Marcello Martinez ; Pohl, Christin ; Roche, Aisling ; Tosstorff, Andreas ; Curtis, Robin ; Derrick, Jeremy P ; Nørgaard, Allan ; Khan, Tarik A ; Peters, Günther H.J. ; Pluen, Alain ; Rinnan, Åsmund ; Streicher, Werner W ; van der Walle, Christopher F ; Uddin, Shahid ; Winter, Gerhard ; Roessner, Dierk ; Harris, Pernille ; Frieß, Wolfgang
in: Molecular Pharmaceutics, vol: 17, issue: 2, pages: 426-440

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1021/acs.molpharmaceut.9b00852

 

Characterization of native reversible self-association of a monoclonal antibody mediated by Fab-Fab interaction

Gentiluomo, Lorenzo ; Roessner, Dierk ; Streicher, Werner ; Mahapatra, Sujata ; Harris, Pernille ; Frieß, Wolfgang
in: Journal of Pharmaceutical Sciences, vol: 109, issue: 1, pages: 443-451

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.xphs.2019.09.021

  PDF

Concentrated protein solutions investigated using acoustic levitation and small-angle X-ray scattering

Sønderby, Pernille ; Söderberg, Christopher ; Frankær, Christian Grundahl ; Peters, Günther H.J. ; Bukrinski, Jens T ; Labrador, Ana ; Plivelic, Tomás S ; Harris, Pernille
in: Journal of Synchrotron Radiation, vol: 27, issue: 2, pages: 396-404

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1107/s1600577519016977

 

Investigations of albumin-insulin detemir complexes using molecular dynamics simulations and free energy calculations

Ryberg, Line A. ; Sønderby, Pernille ; Bukrinski, Jens T. ; Harris, Pernille ; Peters, Günther H. J.
in: Molecular Pharmaceutics, vol: 17, issue: 1, pages: 132-144

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1021/acs.molpharmaceut.9b00839

 

Orthogonal techniques to study the effect of pH, sucrose and arginine salts on monoclonal antibody physical stability and aggregation during long-term storage

Svilenov, Hristo L. ; Kulakova, Alina ; Zalar, Matja ; Golovanov, Alexander P. ; Harris, Pernille ; Winter, Gerhard
in: Journal of Pharmaceutical Sciences, vol: 109, issue: 1, pages: 584-594

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.xphs.2019.10.065

  PDF

Small angle X-ray scattering and molecular dynamic simulations provide molecular insight for stability of recombinant human transferrin

Kulakova, Alina ; Indrakumar, Sowmya ; Sønderby, Pernille ; Gentiluomo, Lorenzo ; Streicher, Werner ; Roessner, Dierk ; Frieß, Wolfgang ; Peters, Günther H.J. ; Harris, Pernille
in: Journal of Structural Biology: X, vol: 4

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.yjsbx.2019.100017

2019
 

A Novel Niobium Cluster Aqua Ion with Capping μ4 -Se Ligand

Gushchin, Artem L. ; Ooi, Bee Lean ; Harris, Pernille ; Abramov, Pavel A. ; Sokolov, Maxim N.
in: Zeitschrift fuer Anorganische und Allgemeine Chemie, vol: 645, issue: 4, pages: 398-401

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/zaac.201800476

  PDF

A pathogenic haplotype, common in Europeans, causes autosomal recessive albinism and uncovers missing heritability in OCA1

Grønskov, Karen ; Jespersgaard, Cathrine ; Bruun, Gitte Hoffmann ; Harris, Pernille ; Brøndum-Nielsen, Karen ; Andresen, Brage S. ; Rosenberg, Thomas
in: Scientific Reports, vol: 9, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41598-018-37272-5

 

Application of interpretable artificial neural networks to early monoclonal antibodies development

Gentiluomo, Lorenzo ; Roessner, Dierk ; Augustijn, Dillen ; Svilenov, Hristo ; Kulakova, Alina ; Mahapatra, Sujata ; Winter, Gerhard ; Streicher, Werner ; Rinnan, Åsmund ; Peters, Günther H.J. ; Harris, Pernille ; Frieß, Wolfgang
in: European Journal of Pharmaceutics and Biopharmaceutics, vol: 141, pages: 81-89

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.ejpb.2019.05.017

 

Conformational Stability Study of a Therapeutic Peptide Plectasin Using Molecular Dynamics Simulations in Combination with NMR

Indrakumar, Sowmya ; Zalar, Matja ; Pohl, Christin ; Nørgaard, Allan ; Streicher, Werner ; Harris, Pernille ; Golovanov, Alexander P. ; Peters, Günther H.J.
in: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, vol: 123, issue: 23, pages: 4867-4877

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1021/acs.jpcb.9b02370