Postdoc in Immunology and Cell Engineering

fredag 07 feb 20

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Frist 15. marts 2020
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Do you want to work on developing next-generation cell therapies for cancer immunotherapy? We are seeking a talented postdoc for interdisciplinary projects involving the engineering of human primary immune cells (for example, CAR-T). The candidate will join the Cell Architecture Group (PI Ryan T. Gill) at the Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain) in Denmark. The Cell Architecture Group is developing cellular engineering technologies based on genome editing (CRISPR) with applications to cell-based therapies in the areas of immunology and stem cells. DTU Biosustain is part of the Technical University of Denmark and provides a world-class research environment with state-of-the-art facilities and advanced technologies with special emphasis on cell factory engineering and systems biology.

Responsibilities and tasks
We are looking for a candidate with demonstrated expertise working with T cells, NK cells, and/or immune oncology. The candidate should have practical, hands-on expertise in the isolation and culture of primary immune cells, analysis of cell subtypes by flow cytometry, and functional analysis of immune cells via cytokine release, cell killing, and other assays. The major responsibilities in the lab will be the functional characterization of novel, genetically engineered primary immune cells. The candidate will work together in a cross-functional team with opportunities to help design novel engineered cells with a focus on developing therapeutic applications.

Specific tasks will include:
  • Isolation and culture of primary human immune cells
  • Lead the design and implementation of functional assays for immune cells, including flow cytometry and FACS
  • Document experimental design and results in electronic lab notebooks
  • Analyze and organize data to draw meaningful conclusions
  • Develop and support the submission of patents and other intellectual property
  • Publish and present at professional meetings as appropriate.
Qualifications
  • Excellence in independent problem solving
  • Have deep laboratory experience within immunology, specifically with T cells, NK cells, and their application to cancer therapy
  • Enjoy sharing knowledge and experience with others
  • Ability to lead multiple projects and support collaborations
  • PhD degree or similar in immunology, biotechnology or equivalent with relevant experience as described above
  • Experience with omics data analysis and familiarity with scripting languages (e.g. Python) is desired, but not required
  • Experience with high-throughput methods and automation are desired, but not required

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice for the benefit of the surrounding community. We offer an interesting and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and an academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed with the relevant union.

Workplace and period of employment
The period of employment is time limited to 2 years.


The place of employment is the DTU main campus in Kgs. Lyngby, Denmark.


You can read more about career paths at DTU here.


Further information
Further information may be obtained from Professor Ryan T. Gill (
ryagil@biosustain.dtu.dk)

You can read more about the Novo Nordisk Foundation Center for Biosustainability at
www.biosustain.dtu.dk


Application procedure
Please submit your online application no later than 15 March 2020 (23:59 local time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill in the online application form, and attach all your materials in English in one PDF file.
The file must include:

  • Application (cover letter)
  • CV
  • Diploma (MSc/PhD)
  • List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Biosustain is an international research center of excellence developing next generation cell factories and bioprocesses for sustainable production of high-value chemical compounds as well as protein-based products. The center uses advanced metabolic engineering techniques and computational biology ensuring efficient and cost-effective design and construction processes.

The center’s activities are a balanced mix of basic and translational research, complemented by an emphasis on business development to facilitate commercialization of new cell factories and associated technologies. DTU Biosustain offers state-of-the-art research facilities and assembles world leaders in the field thus offering a unique platform providing excellent talent development and career opportunities.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 11,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.