Jesper Holck

Jesper Holck

Seniorforsker

DTU BIOENGINEERING
Institut for Bioteknologi og Biomedicin

Danmarks Tekniske Universitet

Søltofts Plads

Bygning 224, rum 033

2800 Kgs. Lyngby

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2019
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A carbohydrate-binding family 48 module enables feruloyl esterase action on polymeric arabinoxylan

Holck, Jesper ; Fredslund, Folmer ; Møller, Marie Sofie ; Brask, Jesper ; Krogh, Kristian B. R. M. ; Lange, Lene ; Welner, Ditte Hededam ; Svensson, Birte ; Meyer, Anne S. ; Wilkens, Casper
in: Journal of Biological Chemistry, vol: 294, issue: 46, pages: 17339-17353

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1074/jbc.RA119.009523

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Enzyme kinetics of fungal glucuronoyl esterases on natural lignin-carbohydrate complexes

Mosbech, Caroline ; Holck, Jesper ; Meyer, Anne ; Agger, Jane Wittrup
in: Applied Microbiology and Biotechnology, vol: 103, issue: 10, pages: 4065-4075

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1007/s00253-019-09797-w

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Identification and characterization of GH11 xylanase and GH43 xylosidase from the chytridiomycetous fungus, Rhizophlyctis rosea

Huang, Yuhong ; Zheng, Xianliang ; Pilgaard, Bo ; Holck, Jesper ; Muschiol, Jan ; Li, Shengying ; Lange, Lene
in: Applied Microbiology and Biotechnology, vol: 103, issue: 2, pages: 777-791

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1007/s00253-018-9431-5

 

Increased trans-glycosylation activity of hexosaminidases for synthesis of human milk oligosaccharides

Muschiol, Jan ; Binti Jamek, Shariza ; Holck, Jesper ; Zeuner, Birgitte ; Busk, Peter Kamp ; Lange, Lene ; Mikkelsen, Jørn Dalgaard ; Meyer, Anne S.
Presented at:
13th Carbohydrate Bioengineering Meeting

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    År: 2019

 

Laccase Induced Lignin Radical Formation Kinetics Evaluated by Electron Paramagnetic Resonance Spectroscopy

Perna, Valentina ; Agger, Jane W. ; Andersen, Mogens L. ; Holck, Jesper ; Meyer, Anne S.
in: ACS Sustainable Chemistry and Engineering, vol: 7, issue: 12, pages: 10425-10434

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1021/acssuschemeng.9b00723

 

Novel xylanolytic triple domain enzyme targeted at feruloylated arabinoxylan degradation

Holck, Jesper ; Brask, Jesper ; Pilgaard, Bo ; Krogh, Kristian B.R.M. ; Meyer, Anne S. ; Lange, Lene ; Wilkens, Casper
in: Enzyme and Microbial Technology, vol: 129

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1016/j.enzmictec.2019.05.010

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Structural and functional aspects of mannuronic acid-specific PL6 alginate lyase from the human gut microbe Bacteroides cellulosilyticus

Stender, Emil G. P. ; Andersen, Christian Dybdahl ; Fredslund, Folmer ; Holck, Jesper ; Solberg, Amalie ; Teze, David ; Peters, Günther H.J. ; Christensen, Bjørn E. ; Aachmann, Finn L. ; Welner, Ditte Hededam ; Svensson, Birte
in: Journal of Biological Chemistry, vol: 294, issue: 47, pages: 17915-17930

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1074/jbc.RA119.010206

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Substrate specificity of novel GH16 endo-β-(1→3)-galactanases acting on linear and branched β-(1→3)-1 galactooligosaccharides

Kalomoiri, Panagiota ; Holck, Jesper ; Coulomb, Laure ; Boos, Irene ; Enemark-Rasmussen, Kasper ; Spodsberg, Nikolaj ; Monrad, Rune Nygaard ; Clausen, Mads Hartvig
in: Journal of Biotechnology, vol: 290, pages: 44-52

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1016/j.jbiotec.2018.12.006

 

Transfucosylation by and engineering of GH29 α-L-fucosidases for production of human milk oligosaccharides

Zeuner, Birgitte ; Holck, Jesper ; Muschiol, Jan ; Vuillemin, Marlene ; Meyer, Anne S.
Presented at:
13th Carbohydrate Bioengineering Meeting

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    År: 2019

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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial

Roager, Henrik Munch ; Vogt, Josef Korbinian ; Kristensen, Mette ; Hansen, Lea Benedicte S ; Ibrügger, Sabine ; Mærkedahl, Rasmus B ; Bahl, Martin Iain ; Lind, Mads Vendelbo ; Nielsen, Rikke Linnemann ; Frøkiær, Hanne ; Gøbel, Rikke Juul ; Landberg, Rikard ; Ross, Alastair B ; Brix, Susanne ; Holck, Jesper ; Meyer, Anne S. ; Sparholt, Morten H ; Christensen, Anders F ; Carvalho, Vera ; Holst, Jens Juul ; Rumessen, Jüri Johannes ; Linneberg, Allan ; Sicheritz-Pontén, Thomas ; Dalgaard, Marlene Danner ; Blennow, Andreas ; Frandsen, Henrik Lauritz ; Villas-Bôas, Silas Granato ; Kristiansen, Karsten ; Vestergaard, Henrik ; Hansen, Torben ; Ekstrøm, Claus T ; Ritz, Christian ; Nielsen, Henrik Bjørn ; Pedersen, Oluf Borbye ; Gupta, Ramneek ; Lauritzen, Lotte ; Licht, Tine Rask
in: Gut, vol: 68, issue: 1, pages: 83-93

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1136/gutjnl-2017-314786

2018
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A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

Hansen, Lea B. S. ; Roager, Henrik M. ; Søndertoft, Nadja B. ; Gøbel, Rikke J. ; Kristensen, Mette ; Vallès-Colomer, Mireia ; Vieira-Silva, Sara ; Ibrügger, Sabine ; Lind, Mads V. ; Mærkedahl, Rasmus B. ; Bahl, Martin Iain ; Madsen, Mia L ; Havelund, Jesper ; Falony, Gwen ; Tetens, Inge ; Nielsen, Trine ; Allin, Kristine H. ; Frandsen, Henrik L ; Hartmann, Bolette ; Holst, Jens Juul ; Sparholt, Morten H. ; Holck, Jesper ; Blennow, Andreas ; Moll, Janne Marie ; Meyer, Anne S. ; Hoppe, Camilla ; Poulsen, Jørgen H. ; Carvalho, Vera ; Sagnelli, Domenico ; Dalgaard, Marlene Danner ; Christensen, Anders F. ; Lydolph, Magnus Christian ; Ross, Alastair B ; Villas-Bôas, Silas ; Brix, Susanne ; Sicheritz-Pontén, Thomas ; Buschard, Karsten ; Linneberg, Allan ; Rumessen, Jüri J. ; Ekstrøm, Claus T. ; Ritz, Christian ; Kristiansen, Karsten ; Nielsen, H. Bjørn ; Vestergaard, Henrik ; Færgeman, Nils J. ; Raes, Jeroen ; Frøkiær, Hanne ; Hansen, Torben ; Gupta, Ramneek ; Licht, Tine Rask ; Pedersen, Oluf
in: Nature Communications, vol: 9, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1038/s41467-018-07019-x

 

Design of a new, accurate laccase activity assay method based on "lignin-like" compounds

Perna, Valentina ; Agger, Jane ; Holck, Jesper ; Meyer, Anne S.
part of: Proceedings of the 255th ACS National Meeting & Exposition, 2018, American Chemical Society
Presented at:
255th ACS National Meeting & Exposition

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    År: 2018

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Loop engineering of an α-1,3/4-L-fucosidase for improved synthesis of human milk oligosaccharides

Zeuner, Birgitte ; Vuillemin, Marlene ; Holck, Jesper ; Muschiol, Jan ; Meyer, Anne S.
in: Enzyme and Microbial Technology, vol: 115, pages: 37-44

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1016/j.enzmictec.2018.04.008

 

Loop Protein Engineering for Improved Transglycosylation Activity of a β-N -Acetylhexosaminidase

Jamek, Shariza B. ; Muschiol, Jan ; Holck, Jesper ; Zeuner, Birgitte ; Busk, Peter K. ; Mikkelsen, Jørn D. ; Meyer, Anne S.
in: Chembiochem, vol: 19, issue: 17, pages: 1858-1865

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1002/cbic.201800181

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Multiple Reaction Monitoring for quantitative laccase kinetics by LC-MS

Perna, Valentina ; Agger, Jane W. ; Holck, Jesper ; Meyer, Anne S.
in: Scientific Reports, vol: 8, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1038/s41598-018-26523-0

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Novel Enzyme Actions for Sulphated Galactofucan Depolymerisation and a New Engineering Strategy for Molecular Stabilisation of Fucoidan Degrading Enzymes

Cao, Hang T. T. ; Mikkelsen, Maria D. ; Lezyk, Mateusz J. ; Bui, Ly M. ; Tran, Van T. T. ; Silchenko, Artem S. ; Kusaykin, Mikhail I. ; Pham, Thinh D. ; Truong, Bang H. ; Holck, Jesper ; Meyer, Anne S.
in: Marine Drugs, vol: 16, issue: 11

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.3390/md16110422

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Substrate specificity and transfucosylation activity of GH29 α-l-fucosidases for enzymatic production of human milk oligosaccharides

Zeuner, Birgitte ; Muschiol, Jan ; Holck, Jesper ; Lezyk, Mateusz ; Gedde, Mattias Raae ; Jers, Carsten ; Mikkelsen, Jørn Dalgaard ; Meyer, Anne S.
in: New Biotechnology, vol: 41, pages: 34-45

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1016/j.nbt.2017.12.002

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The natural catalytic function of CuGE glucuronoyl esterase in hydrolysis of genuine lignin-carbohydrate complexes from birch

Mosbech, Caroline ; Holck, Jesper ; Meyer, Anne S. ; Wittrup Agger, Jane
in: Biotechnology for Biofuels, vol: 11

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1186/s13068-018-1075-2

2017
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Characterization and immobilization of engineered sialidases from Trypanosoma rangeli for transsialylation

Zeuner, Birgitte ; González-Delgado, Isabel ; Holck, Jesper ; Morales, Gabriel ; López-Muñoz, María-José ; Segura, Yolanda ; Meyer, Anne S. ; Mikkelsen, Jørn Dalgaard
in: Aims Molecular Science, vol: 4, issue: 2, pages: 140-163

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.3934/molsci.2017.2.140

 

Characterization of two novel bacterial type A exo-chitobiose hydrolases having C-terminal 5/12-type carbohydrate-binding modules

Binti Jamek, Shariza ; Nyffenegger, Christian ; Muschiol, Jan ; Holck, Jesper ; Meyer, Anne S. ; Mikkelsen, Jørn Dalgaard
in: Applied Microbiology and Biotechnology, vol: 101, issue: 11, pages: 4533–4546

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1007/s00253-017-8198-4

 

Oxidation of lignin in hemp fibres by laccase: effects on mechanical properties of hemp fibres and unidirectional fibre/epoxy composites

Liu, Ming ; Baum, Andreas ; Odermatt, Jürgen ; Berger, Jens ; Yu, Liyun ; Zeuner, Birgitte ; Thygesen, Anders ; Holck, Jesper ; Meyer, Anne S.
in: Composites Part A: Applied Science and Manufacturing, vol: 95, pages: 377–387

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1016/j.compositesa.2017.01.026

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Prebiotic potential of pectin and pectic oligosaccharides to promote anti-inflammatory commensal bacteria in the human colon

Chung, Wing Sun Faith ; Meijerink, Marjolein ; Zeuner, Birgitte ; Holck, Jesper ; Louis, Petra ; Meyer, Anne S. ; Wells, Jerry M ; Flint, Harry J ; Duncan, Sylvia H
in: FEMS Microbiology Ecology, vol: 93, issue: 11

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2017     |    DOI: https://doi.org/10.1093/femsec/fix127

2016
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It All Starts with a Sandwich: Identification of Sialidases with Trans-Glycosylation Activity

Nordvang, Rune Thorbjørn ; Nyffenegger, Christian ; Holck, Jesper ; Jers, Carsten ; Zeuner, Birgitte ; Sundekilde, Ulrik K. ; Meyer, Anne S. ; Mikkelsen, Jørn Dalgaard
in: P L o S One, vol: 11, issue: 7

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1371/journal.pone.0158434

 

Oxidation of lignin in hemp fibres by laccase: effects on mechanical properties of hemp fibres and unidirectional fibre/epoxy composites

Liu, Ming ; Baum, Andreas ; Odermatt, Jürgen ; Berger, Jens ; Yu, Liyun ; Zeuner, Birgitte ; Thygesen, Anders ; Holck, Jesper ; Meyer, Anne S.
Presented at:
Sustain-ATV Conference 2016

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    År: 2016

 

Quantitative enzymatic production of sialylated galactooligosaccharides with an engineered sialidase from Trypanosoma rangeli

Zeuner, Birgitte ; Holck, Jesper ; Perna, Valentina ; Mikkelsen, Jørn Dalgaard ; Meyer, Anne S.
in: Enzyme and Microbial Technology, vol: 82, pages: 42-50

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2016     |    DOI: https://doi.org/10.1016/j.enzmictec.2015.08.010

2014
 

Enzymatic production of human milk oligosaccharides

Holck, Jesper ; Jers, Carsten ; Michalak, Malwina ; Zeuner, Birgitte ; Guo, Yao ; Meyer, Anne S. ; Mikkelsen, Jørn Dalgaard
part of: Abstract Book - DTU Sustain Conference 2014, 2014, Technical University of Denmark, Kgs. Lyngby
Presented at:
DTU Sustain Conference 2014

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    År: 2014

 

Enzyme catalysed production of sialylated human milk oligosaccharides and galactooligosaccharides by Trypanosoma cruzi trans-sialidase

Holck, Jesper ; Larsen, Dorte Møller ; Michalak, Malwina ; Li, Haiying ; Kjærulff, Louise ; Kirpekar, Finn ; Gotfredsen, Charlotte Held ; Forssten, Sofia ; Ouwehand, Arthur C. ; Mikkelsen, Jørn Dalgaard ; Meyer, Anne S.
in: New Biotechnology, vol: 31, issue: 2, pages: 156-165

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2014     |    DOI: https://doi.org/10.1016/j.nbt.2013.11.006

2012
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In vitro fermentation of sugar beet arabino-oligosaccharides by fecal microbiota obtained from patients with ulcerative colitis to selectively stimulate the growth of Bifidobacterium spp. and Lactobacillus spp.

Vigsnæs, Louise Kristine ; Holck, Jesper ; Meyer, Anne S. ; Licht, Tine Rask
Presented at:
7th Danish Conference on Biotechnology and Molecular Biology

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    År: 2012

2011
 

Feruloylated and Nonferuloylated Arabino-oligosaccharides from Sugar Beet Pectin Selectively Stimulate the Growth of Bifidobacterium spp. in Human Fecal in Vitro Fermentations

Holck, Jesper ; Lorentzen, Andrea ; Vigsnæs, Louise Kristine ; Licht, Tine Rask ; Mikkelsen, Jørn Dalgaard ; Meyer, Anne S.
in: Journal of Agricultural and Food Chemistry, vol: 59, issue: 12, pages: 6511–6519

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2011     |    DOI: https://doi.org/10.1021/jf200996h

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Kinetics of enzyme-catalyzed cross-linking of feruloylated arabinan from sugar beet

Abang Zaidel, Dayang Norulfairuz ; Arnous, Anis ; Holck, Jesper ; Meyer, Anne S.
in: Journal of Agricultural and Food Chemistry, vol: 59, pages: 11598-11607

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2011     |    DOI: https://doi.org/10.1021/jf203138u

2010
 

Effects of specific carbohydrates on the intestinal microbiota

Hemmingsen, Lene ; Holck, Jesper ; Meyer, Anne S. ; Wilcks, Andrea ; Licht, Tine Rask
Presented at:
TNO Beneficial Microbes Conference

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    År: 2010