Gyun Min Lee

Gyun Min Lee

Scientific Director

DTU BIOSUSTAIN
Novo Nordisk Foundation Center for Biosustainability

CFB-S-CHO Cell Line Engineering And Design

Danmarks Tekniske Universitet

Kemitorvet

Bygning 220, rum 506F

2800 Kgs. Lyngby

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Publikationer
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2020
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Awakening dormant glycosyltransferases in CHO cells with CRISPRa

Julie la Cour Karottki, Karen ; Hefzi, Hooman ; Xiong, Kai ; Shamie, Isaac ; Hansen, Anders Holmgaard ; Li, Songyuan ; Pedersen, Lasse Ebdrup ; Li, Shangzhong ; Lee, Jae Seong ; Min Lee, Gyun ; Kildegaard, Helene Faustrup ; Lewis, Nathan E.
in: Biotechnology and Bioengineering, vol: 117, issue: 2, pages: 593-598

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2020     |    DOI: https://doi.org/10.1002/bit.27199

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Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

Gutierrez, Jahir M ; Feizi, Amir ; Li, Shangzhong ; Kallehauge, Thomas B ; Hefzi, Hooman ; Grav, Lise Marie ; Ley, Daniel ; Baycin Hizal, Deniz ; Betenbaugh, Michael J ; Voldborg, Bjørn Gunnar ; Kildegaard, Helene Faustrup ; Min Lee, Gyun ; Palsson, Bernhard O ; Nielsen, Jens ; Lewis, Nathan E
in: Nature Communications, vol: 11, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2020     |    DOI: https://doi.org/10.1038/s41467-019-13867-y

 

Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Sergeeva, Daria ; Min Lee, Gyun ; Nielsen, Lars Keld ; Grav, Lise Marie
in: ACS Synthetic Biology, vol: 9, issue: 9, pages: 2546-2561

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2020     |    DOI: https://doi.org/10.1021/acssynbio.0c00322

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Multiplex secretome engineering enhances recombinant protein production and purity

Kol, Stefan ; Ley, Daniel ; Wulff, Tune ; Decker, Marianne ; Arnsdorf, Johnny ; Schoffelen, Sanne ; Hansen, Anders Holmgaard ; Jensen, Tanja Lyholm ; Gutierrez, Jahir M. ; Chiang, Austin W. T. ; Masson, Helen O. ; Palsson, Bernhard O. ; Voldborg, Bjørn Gunnar ; Pedersen, Lasse Ebdrup ; Kildegaard, Helene Faustrup ; Min Lee, Gyun ; Lewis, Nathan E.
in: Nature Communications, vol: 11, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2020     |    DOI: https://doi.org/10.1038/s41467-020-15866-w

2019
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BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Kwang Ha, Tae ; Hansen, Anders H ; Kildegaard, Helene Faustrup ; Min Lee, Gyun
in: Biotechnology Journal

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1002/biot.201900130

 

Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines

Kim, Che Lin ; Min Lee, Gyun
in: Metabolic Engineering, vol: 52, pages: 57-67

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1016/j.ymben.2018.11.003

 

Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

Lee, Jae Seong ; Kildegaard, Helene Faustrup ; Lewis, Nathan E ; Min Lee, Gyun
in: Trends in Biotechnology, vol: 37, issue: 9, pages: 931-942

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1016/j.tibtech.2019.02.007

 

Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference

Xiong, Kai ; Marquart, Kim Fabiano ; Julie la Cour Karottki, Karen ; Li, Shangzhong ; Shamie, Isaac ; Lee, Jae Seong ; Gerling, Signe ; Yeo, Nan Cher ; Chavez, Alejandro ; Min Lee, Gyun ; Lewis, Nathan E ; Kildegaard, Helene Faustrup
in: Biotechnology and Bioengineering, vol: 116, issue: 7, pages: 1813-1819

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1002/bit.26969