Gyun Min Lee

Gyun Min Lee

Scientific Director

DTU BIOSUSTAIN
Novo Nordisk Foundation Center for Biosustainability

CFB-S-CHO Cell Line Engineering And Design

Danmarks Tekniske Universitet

Kemitorvet

Bygning 220, rum 506F

2800 Kgs. Lyngby

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Publikationer
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2019
 

BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Kwang Ha, Tae ; Hansen, Anders H ; Kildegaard, Helene Faustrup ; Min Lee, Gyun
in: Biotechnology Journal

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1002/biot.201900130

 

Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines

Kim, Che Lin ; Min Lee, Gyun
in: Metabolic Engineering, vol: 52, pages: 57-67

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1016/j.ymben.2018.11.003

 

Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

Lee, Jae Seong ; Kildegaard, Helene Faustrup ; Lewis, Nathan E ; Min Lee, Gyun
in: Trends in Biotechnology

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    År: 2019     |    DOI: https://doi.org/10.1016/j.tibtech.2019.02.007

 

Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference

Xiong, Kai ; Marquart, Kim Fabiano ; Julie la Cour Karottki, Karen ; Li, Shangzhong ; Shamie, Isaac ; Lee, Jae Seong ; Gerling, Signe ; Yeo, Nan Cher ; Chavez, Alejandro ; Min Lee, Gyun ; Lewis, Nathan E ; Kildegaard, Helene Faustrup
in: Biotechnology and Bioengineering, vol: 116, issue: 7, pages: 1813-1819

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1002/bit.26969

 

Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering

Pristovšek, Nuša ; Nallapareddy, Saranya ; Grav, Lise Marie ; Hefzi, Hooman ; Lewis, Nathan E. ; Rugbjerg, Peter ; Hansen, Henning Gram ; Lee, Gyun Min ; Andersen, Mikael Rørdam ; Kildegaard, Helene Faustrup
in: ACS Synthetic Biology, vol: 8, issue: 4, pages: 758-774

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2019     |    DOI: https://doi.org/10.1021/acssynbio.8b00453

2018
  PDF

Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity

Kwang Ha, Tae ; Hansen, Anders Holmgaard ; Kol, Stefan ; Kildegaard, Helene Faustrup ; Min Lee, Gyun
in: Biotechnology Journal, vol: 13, issue: 3

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1002/biot.201700425

  PDF

Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min ; Shin, Seunghyeon ; Min Lee, Gyun
in: Scientific Reports, vol: 8

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1038/s41598-018-23720-9

 

Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation

Grav, Lise Marie ; Sergeeva, Daria ; Lee, Jae Seong ; Marín de Mas, Igor ; Lewis, Nathan E. ; Andersen, Mikael Rørdam ; Nielsen, Lars Keld ; Min Lee, Gyun ; Kildegaard, Helene Faustrup
in: A C S Synthetic Biology, vol: 7, issue: 9, pages: 2148-2159

Type: Journal article (Peer reviewed)

Status: Published     |    År: 2018     |    DOI: https://doi.org/10.1021/acssynbio.8b00140