Morten Leth Jepsen

PhD defence by Morten Leth Jepsen

On Friday 21 February, Morten Leth Jepsen will defend his PhD thesis "Connected In Vitro Tissue Models for Oral Drug Delivery".

Time: 13:00
Place: Bldg. 341, aud, 21

Supervisor: Associate Professor Martin Dufva
Co-Supervisor: Professor Anja Boisen
Co-Supervisor: Associate Professor Line Hagner Nielsen

Evaluation board:
Assistant Professor Johan Ulrik Lind, DTU Health Tech
Professor Bente Steffensen, LeoPharma
Professor My Hedhammar, Royal Institute of Technology

Chairman:
Asoociate Professor Stephan Sylvest Keller

Abstract:
Oral medicines are preferred amongst patients, however, many new oral medicines fail in clinical trials. Therefore, development of oral medicines is a long and expensive process. Oral medicines can have difficulties with getting from the digestive system to their specific target. The digestive system can act as a barrier and medicines can be broken down by the liver on their way to the target. It is difficult to predict how much of the given dose of oral medicine that reaches its target. Current, prediction tools rely on animal testing or simple cell based models of individual organs grown on hard plastic surfaces. Animal testing come with ethical considerations and models of individual organ do not capture the complexity of the human body. Therefore, there is a need for new tools to predict better how oral medicines behave in the human body.
This PhD project presents a method of connecting cell based organ models to achieve a better resemblance of the human body. Models of the small intestine, the blood vessels, and the liver are connected to mimic the route an oral medicine would travel to its target. Thereby, the complexity of oral medicines was to their target is captured. The cells of the organ models grow on soft gels resembling the softness of organ in the human body. Thereby, the models resemble organs of the human body more than models grown on hard plastic surfaces. The small intestinal model acts as a barrier as what is found for the organ in the human body. The liver model has the same growth profile as found in the human. The blood vessel model connect the small intestinal and the liver models. The presented method has the potential of lowering the cost of development of oral medicines and the need to animal testing

 

 

Tidspunkt

fre 21 feb 20
13:00 - 16:00

Arrangør

DTU Sundhedsteknologi

Hvor

Bldg. 341, aud. 23