Trine Klein Reffstrup

Trine Klein Reffstrup

Academic Officer

National Food Institute, Technical University of Denmark

Division for Risk Assessment and Nutrition

Technical University of Denmark

Mørkhøj Bygade 19

Building C, room 123

2860 Søborg

Fax +45 35 88 70 01
ORCID 0000-0001-9977-3377
Home page

Request a vCard via e-mail.

DTU news


Keywords QSAR | Combined actions | PBTK models | Toxicology - Risk Assessment

My main areas of work are QSAR and PBTK modelling:

- (Quantitative) Structure Activity Relationships ((Q)SARs) are the relationships between the structural properties of chemical substances and another property e.g. a physico-chemical property or a biological activity, including the ability to cause toxic effects. QSAR models can be used to predict properties of substances for which there are lack of experimental data. Thereby the models can reduce the number of animal tests necessary in the assessment of chemical substances, increase the information for a given substance (including metabolites and degradation products), and save companies and authorities time and money. In the EU legislation, REACH, it is expected that (Q)SARs will be used as a direct replacement for test data as relevant and reliable models become increasingly available, and as experience in their use becomes more widespread.

- In a physiologically based toxicokinetic (PBTK) model the animal or man is described as a set of tissue compartments which is combined by mathematical descriptions of biological tissues and physiological processes in the body. Thereby it is possible to quantitatively simulate the absorption, distribution, metabolism and excretion of chemicals and to predict the internal dose after exposure to the chemical (or its metabolite) of concern which can be useful in the risk assessment.