Kai Blin

Kai Blin

Researcher

DTU BIOSUSTAIN
Novo Nordisk Foundation Center for Biosustainability

Technical University of Denmark

Kemitorvet

Building 220, room 326F

2800 Kgs. Lyngby

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2020
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ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining

Mungan, Mehmet Direnç ; Alanjary, Mohammad ; Blin, Kai ; Weber, Tilmann ; Medema, Marnix H. ; Ziemert, Nadine
in: Nucleic acids research, vol: 48, issue: W1, pages: W546-W552

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1093/nar/gkaa374

 

CRISPR–Cas9, CRISPRi and CRISPR-BEST-mediated genetic manipulation in streptomycetes

Tong, Yaojun ; Whitford, Christopher M. ; Blin, Kai ; Jørgensen, Tue S. ; Weber, Tilmann ; Lee, Sang Yup
in: Nature Protocols, vol: 15, issue: 8, pages: 2470-2502

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1038/s41596-020-0339-z

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Designing sgRNAs for CRISPR-BEST base editing applications with CRISPy-web 2.0

Blin, Kai ; Shaw, Simon ; Tong, Yaojun ; Weber, Tilmann
in: Synthetic and Systems Biotechnology, vol: 5, issue: 2, pages: 99-102

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.synbio.2020.05.005

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Disclosing the Potential of the SARP-Type Regulator PapR2 for the Activation of Antibiotic Gene Clusters in Streptomycetes

Krause, Janina ; Handayani, Ira ; Blin, Kai ; Kulik, Andreas ; Mast, Yvonne
in: Frontiers in Microbiology, vol: 11

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.3389/fmicb.2020.00225

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MIBiG 2.0: a repository for biosynthetic gene clusters of known function

Kautsar, Satria A ; Blin, Kai ; Shaw, Simon ; Navarro-Muñoz, Jorge C ; Terlouw, Barbara R ; van der Hooft, Justin J J ; van Santen, Jeffrey A ; Tracanna, Vittorio ; Suarez Duran, Hernando G ; Pascal Andreu, Victòria ; Selem-Mojica, Nelly ; Alanjary, Mohammad ; Robinson, Serina L ; Lund, George ; Epstein, Samuel C ; Sisto, Ashley C ; Charkoudian, Louise K ; Collemare, Jérôme ; Linington, Roger G ; Weber, Tilmann ; Medema, Marnix H
in: Nucleic acids research, vol: 48, pages: D454–D458

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1093/nar/gkz882

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Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast

Jakočiūnas, Tadas ; Klitgaard, Andreas K. ; Kontou, Eftychia Eva ; Nielsen, Julie Bang ; Thomsen, Emil ; Romero Suarez, David ; Blin, Kai ; Petzold, Christopher J. ; Gin, Jennifer W. ; Tong, Yaojun ; Gotfredsen, Charlotte Held ; Charusanti, Pep ; Frandsen, Rasmus J. N. ; Weber, Tilmann ; Lee, Sang Yup ; Jensen, Michael Krogh ; Keasling, Jay D.
in: Synthetic and Systems Biotechnology, vol: 5, issue: 1, pages: 11-18

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.synbio.2020.01.004

2019
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antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

Blin, Kai ; Shaw, Simon ; Steinke, Katharina ; Villebro, Rasmus ; Ziemert, Nadine ; Lee, Sang Yup ; Medema, Marnix H ; Weber, Tilmann
in: Nucleic acids research, vol: 87, issue: W2, pages: W81-W87

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1093/nar/gkz310

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Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST

Tong, Yaojun ; Whitford, Christopher M. ; Robertsen, Helene L. ; Blin, Kai ; Jørgensen, Tue S. ; Klitgaard, Andreas K. ; Gren, Tetiana ; Jiang, Xinglin ; Weber, Tilmann ; Lee, Sang Yup
in: Proceedings of the National Academy of Sciences of the United States of America, vol: 116, issue: 41, pages: 20366-20375

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1073/pnas.1913493116

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Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters

Blin, Kai ; Kim, Hyun Uk ; Medema, Marnix H. ; Weber, Tilmann
in: Briefings in Bioinformatics, vol: 20, issue: 4, pages: 1103-1113

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1093/bib/bbx146

 

Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH

Villebro, Rasmus ; Shaw, Simon ; Blin, Kai ; Weber, Tilmann
in: Journal of Industrial Microbiology and Biotechnology, vol: 46, issue: 3-4, pages: 469-475

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1007/s10295-018-02131-9