Lars Keld Nielsen

Lars Keld Nielsen

Scientific Director

DTU BIOSUSTAIN
Novo Nordisk Foundation Center for Biosustainability

Technical University of Denmark

Kemitorvet

Building 220, room 504F

2800 Kgs. Lyngby

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2020
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Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production

Bongers, Mareike ; Perez-Gil, Jordi ; Hodson, Mark P. ; Schrübbers, Lars ; Wulff, Tune ; Sommer, Morten Oa ; Nielsen, Lars K. ; Vickers, Claudia E.
in: eLife, vol: 9

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.7554/elife.48685

 

Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Henry, Matthew N. ; MacDonald, Michael A. ; Orellana, Camila A. ; Gray, Peter P. ; Gillard, Marianne ; Baker, Kym ; Nielsen, Lars K. ; Marcellin, Esteban ; Mahler, Stephen ; Martínez, Verónica S.
in: Biotechnology and Bioengineering, vol: 17, issue: 4, pages: 1187-1203

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1002/bit.27269

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Lactate reduction in CHO cell cultures through metabolic analysis

Monge, Ivan Martinez ; Hefzi, Hooman ; Sanchez, Pere Comas ; Marín de Mas, Igor Batolomé ; Decker, Marianne ; Lecina, Martí ; Cairó, Jordi Joan ; Lewis, Nathan ; Nielsen, Lars Keld

Type: Poster (Peer reviewed)

Status: Published     |    Year: 2020

 

Multicopy Targeted Integration for Accelerated Development of High-Producing Chinese Hamster Ovary Cells

Sergeeva, Daria ; Min Lee, Gyun ; Nielsen, Lars Keld ; Grav, Lise Marie
in: ACS Synthetic Biology, vol: 9, issue: 9, pages: 2546-2561

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1021/acssynbio.0c00322

2019
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Stoichiometric gene-to-reaction associations enhance model-driven analysis performance: Metabolic response to chronic exposure to Aldrin in prostate cancer

Marín de Mas, Igor Batolomé ; Torrents, Laura ; Bedia, Carmen ; Nielsen, Lars K ; Cascante, Marta ; Tauler, Romà
in: BMC Genomics, vol: 20, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1186/s12864-019-5979-4

2018
 

Advances in analytical tools for high throughput strain engineering

Marcellin, Esteban ; Nielsen, Lars Keld
in: Current Opinion in Biotechnology, vol: 54, pages: 33-40

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.copbio.2018.01.027

 

An Expanded Heterologous GAL Promoter Collection for Diauxie-Inducible Expression in Saccharomyces cerevisiae

Peng, Bingyin ; Wood, Rebecca J. ; Nielsen, Lars K. ; Vickers, Claudia E.
in: A C S Synthetic Biology, vol: 7, issue: 2, pages: 748-751

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1021/acssynbio.7b00355

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Engineered protein degradation of farnesyl pyrophosphate synthase is an effective regulatory mechanism to increase monoterpene production in Saccharomyces cerevisiae

Peng, Bingyin ; Nielsen, Lars K. ; Kampranis, Sotirios C ; Vickers, Claudia E
in: Metabolic Engineering, vol: 47, pages: 83-93

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.ymben.2018.02.005

 

From reconstruction to C4 metabolic engineering: A case study for overproduction of polyhydroxybutyrate in bioenergy grasses

Gomes de Oliveira Dal'Molin, Cristiana ; Quek, Lake-Ee ; Saa, Pedro A. ; Palfreyman, Robin ; Nielsen, Lars Keld
in: Plant Science, vol: 273, pages: 50-60

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.plantsci.2018.03.027

 

Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

Buchsteiner, Maria ; Quek, Lake-Ee ; Gray, Peter ; Nielsen, Lars K.
in: Biotechnology and Bioengineering, vol: 115, issue: 9, pages: 2315-2327

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1002/bit.26724