Luca Laraia

Luca Laraia

Assistant Professor

DTU CHEMISTRY
Department of Chemistry

Kemi: Faculty
Organisk Kemi: Jens Ø Duus

Technical University of Denmark

Kemitorvet

Building 207, room 124

2800 Kgs. Lyngby

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2020
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Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1

Huggins, David J. ; Hardwick, Bryn S. ; Sharma, Pooja ; Emery, Amy ; Laraia, Luca ; Zhang, Fengzhi ; Narvaez, Ana J. ; Roberts-Thomson, Meredith ; Crooks, Alex T. ; Boyle, Robert G. ; Boyce, Richard ; Walker, David W. ; Mateu, Natalia ; McKenzie, Grahame J. ; Spring, David R. ; Venkitaraman, Ashok R.
in: ACS Omega, vol: 5, issue: 1, pages: 822-831

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1021/acsomega.9b03626

 

Phenotyping reveals the targets of a pseudo-natural product autophagy inhibitor

Foley, Daniel J. ; Zinken, Sarah ; Corkery, Dale ; Laraia, Luca ; Pahl, Axel ; Wu, Yaowen ; Waldmann, Herbert
in: Angewandte Chemie International Edition

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1002/anie.202000364

 

Phenotyping reveals the targets of a pseudo-natural product autophagy inhibitor

Foley, Daniel J. ; Zinken, Sarah ; Corkery, Dale ; Laraia, Luca ; Pahl, Axel ; Wu, Yaowen ; Waldmann, Herbert
in: Angewandte Chemie

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1002/ange.202000364

 

Principle and design of pseudo-natural products

Karageorgis, George ; Foley, Daniel J. ; Laraia, Luca ; Waldmann, Herbert
in: Nature Chemistry, vol: 12, issue: 3, pages: 227–235

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1038/s41557-019-0411-x

2019
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EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology

Brennecke, Philip ; Rasina, Dace ; Aubi, Oscar ; Herzog, Katja ; Lanskron, Johannes ; Cautain, Bastien ; Vicente, Francisca ; Quintana, Jordi ; Stechmann, Bahne ; Brea, Jose ; Kolanowski, Jacek ; Pilarski, Radoslaw ; Orzaez, Mar ; Pienda-Lucena, Antonio ; Laraia, Luca ; Nami, Faranak ; Zielenkiewicz, Piotr ; Paruch, Kamil ; Hansen, Espen ; von Kries, Jens ; Neuenschwander, Martin ; Specker, Edgar ; Bartunek, Petr ; Simova, Sarka ; Lesinikowski, Zbigniew ; Krauss, Stefan ; Lëhtio, Lari ; Bilitewski, Ursula ; Broenstrup, Mark ; Tásken, Kjetil ; Lickert, Heiko ; Clausen, Mads Hartvig ; Andersen, Jeanette ; Vicent, Maria ; Genilloud, Olga ; Martinez, Aurora ; Nazaré, Marc ; Gribbon, Philip ; Fecke, Wolfgang
in: SLAS DISCOVERY: Advancing Life Sciences R&D, vol: 24, issue: 3, pages: 398-413

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1177/2472555218816276

 

Modulation of autophagy by the novel mitochondrial complex I inhibitor Authipyrin

Kaiser, Nadine ; Corkery, Dale ; Wu, Yaowen ; Laraia, Luca ; Waldmann, Herbert
in: Bioorganic and Medicinal Chemistry, vol: 27, issue: 12, pages: 2444-2448

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.bmc.2019.02.028

 

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

Laraia, Luca ; Friese, Alexandra ; Corkery, Dale P. ; Konstantinidis, Georgios ; Erwin, Nelli ; Hofer, Walter ; Karatas, Hacer ; Klewer, Laura ; Brockmeyer, Andreas ; Metz, Malte ; Schölermann, Beate ; Dwivedi, Mridula ; Li, Lei ; Rios-Munoz, Pablo ; Köhn, Maja ; Winter, Roland ; Vetter, Ingrid R. ; Ziegler, Slava ; Janning, Petra ; Wu, Yao Wen ; Waldmann, Herbert
in: Nature Chemical Biology, vol: 15, issue: 7, pages: 710-720

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41589-019-0307-5

2018
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Bioactive Compound Collections: From Design to Target Identification

Laraia, Luca ; Robke, Lucas ; Waldmann, Herbert
in: Chemical Engineering Progress, vol: 4, issue: 4, pages: 705-730

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.chempr.2018.01.012

 

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

Robke, Lucas ; Rodrigues, Tiago ; Schröder, Peter ; Foley, Daniel J. ; Bernardes, Gonçalo J.L. ; Laraia, Luca ; Waldmann, Herbert
in: Tetrahedron, vol: 74, pages: 4531-4537

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.tet.2018.07.021

2017
 

Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors

Laraia, Luca ; Ohsawa, Kosuke ; Konstantinidis, Georgios ; Robke, Lucas ; Wu, Yao-Wen ; Kumar, Kamal ; Waldmann, Herbert
in: Angewandte Chemie, vol: 129, issue: 8, pages: 2177–2182

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1002/ange.201611670