Lone Gram

Lone Gram


Institut for Bioteknologi og Biomedicin

Danmarks Tekniske Universitet

Søltofts Plads

Bygning 221, rum 140

2800 Kgs. Lyngby

Fax 45 93 28 09
E-mail gram@bio.dtu.dk
ORCID 0000-0002-1076-5723

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DTU nyheder



1980 - 1985
Food Science, The Royal Veterinary and Agricultural University, Denmark

Akademiske Grader

Ph.D. (1989, Microbiology), M.Sc. (1985, Food Science)


2011 -
Techncial University of Denmark, Professor
2005 - 2010
Technical University of Denmark, Research Professor
2000 - 2005
National Institute for Fisheries Research, Research Council Professor
1993 - 2000
National Institute for Fisheries Research, Senior scientist
1988 - 1993
Technological Laboratory, Scientist
1986 - 1989
The Royal Veterinary and Agricultural University, PhD student
2013 -
Technical University of Denmark, Dept. of Systems Biology, Professor


Danish (mother tongue), English (fluent)


My group studies the ecology and physiology of aquatic microorganisms. This includes studies of bacteria such as Roseobacter, Pseudoalteromonas, Vibrio, Shewanella, fluorescent pseudomonads or Listeria monocytogenes. Part of the work deals with pathogenic bacteria and food safety and infection (Gram 2005, Gram and Huss 2000) and part of the work with the biotechnological potential of marine bacteria (Gram et al. 2010). We work on control on unwanted bacteria (pathogens and spoilage bacteria) and work with both live fish and seafood products. Also, we have a more general interst in the development of novel antibacterial compounds (such as small organic molecules, antimicrobial peptides, enzymes) that may be used in clinical settings or as antifouling agents. Our work with L. monocytogenes focuses on seafood safety and we study environmental niches, spread, colonization, inhibition and virulence of the bacterium. We are interested in aquacultured fish species; in particular non-antibiotic based disease control methods such as probiotics or blocking of bacteria quorum sensing. Potential fish probiotics include Roseobacter and Pseudomonas species. Methods range from traditional culturing, phenotypic characterization to typing by RAPD and antibody and probe detection. Several of our current research projects deal with various aspects of interactions between bacteria and between bacteria and the eucaryotic host . We use the understanding of bacteria-bacteria-interactions (especially antagonism) to search for novel antibacterial compounds. In 2006, we have joined a global scientific marin cruise (Galathea3) where we will determine the distribution of bacteria with antibacterial activity in the marine environment around the globe. This work can potentially be of interest in development of novel food preservation compounds, antifouling agents and even in drug discovery work.

International erfaring

2009: Research visit to Harvard Medical School (4 months) 1999: Research visit to University of New South Wales (1½ month) 1995: Research visit to University of New South Wales (7 months) 2006-to date: Adjunct Professor at University of Maryland 1998-2009 Member and 2003-2007 secretary of ICMSF; the International Commission on Microbiological Specifications for Foods 1986-1993: Several consultancies for the Food and Agricultural Organization of the United Nations working on projects and courses in Africa related to fish technology

Anden information

2008: Awarded Kaufmann's Mindefond and Tagea Brandt's travel award 2007-to date: Editor of Applied and Environmental Microbiology.2006-2012. Member of the Danish Council for Research Policy 2008-2011. Member since 2013 of the Danish Research Council for Natural Sciences.

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